ID H2MIX9_ORYLA Unreviewed; 934 AA.
AC H2MIX9;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 71.
DE SubName: Full=Complement component 6 {ECO:0000313|Ensembl:ENSORLP00000018612.2};
GN Name=c6 {ECO:0000313|Ensembl:ENSORLP00000018612.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000018612.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000018612.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000018612.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000018612.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000018612.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the complement C6/C7/C8/C9 family.
CC {ECO:0000256|ARBA:ARBA00009214}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00302}.
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DR RefSeq; XP_004075187.1; XM_004075139.2.
DR RefSeq; XP_011480403.1; XM_011482101.1.
DR AlphaFoldDB; H2MIX9; -.
DR STRING; 8090.ENSORLP00000018612; -.
DR Ensembl; ENSORLT00000018613.2; ENSORLP00000018612.2; ENSORLG00000014843.2.
DR GeneID; 101156343; -.
DR KEGG; ola:101156343; -.
DR CTD; 729; -.
DR eggNOG; ENOG502QPIM; Eukaryota.
DR GeneTree; ENSGT00940000156814; -.
DR HOGENOM; CLU_014082_0_0_1; -.
DR InParanoid; H2MIX9; -.
DR OrthoDB; 5303272at2759; -.
DR TreeFam; TF330498; -.
DR Proteomes; UP000001038; Chromosome 12.
DR Bgee; ENSORLG00000014843; Expressed in muscle tissue and 11 other cell types or tissues.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005579; C:membrane attack complex; IBA:GO_Central.
DR GO; GO:0006956; P:complement activation; IBA:GO_Central.
DR GO; GO:0006958; P:complement activation, classical pathway; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
DR CDD; cd00033; CCP; 2.
DR CDD; cd00112; LDLa; 1.
DR Gene3D; 3.30.60.30; -; 2.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 2.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 1.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 3.
DR InterPro; IPR048828; C6_KAZAL.
DR InterPro; IPR048831; C8A_B_C6_EGF-like.
DR InterPro; IPR003884; FacI_MAC.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR InterPro; IPR001862; MAC_perforin.
DR InterPro; IPR020864; MACPF.
DR InterPro; IPR020863; MACPF_CS.
DR InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR PANTHER; PTHR45742; COMPLEMENT COMPONENT C6; 1.
DR PANTHER; PTHR45742:SF4; COMPLEMENT COMPONENT C6; 1.
DR Pfam; PF21288; C6_KAZAL; 1.
DR Pfam; PF21195; C8A_B_C6_EGF-like; 1.
DR Pfam; PF00057; Ldl_recept_a; 1.
DR Pfam; PF01823; MACPF; 1.
DR Pfam; PF00084; Sushi; 2.
DR Pfam; PF00090; TSP_1; 3.
DR PRINTS; PR00764; COMPLEMENTC9.
DR SMART; SM00032; CCP; 2.
DR SMART; SM00057; FIMAC; 2.
DR SMART; SM00192; LDLa; 1.
DR SMART; SM00457; MACPF; 1.
DR SMART; SM00209; TSP1; 3.
DR SUPFAM; SSF57535; Complement control module/SCR domain; 2.
DR SUPFAM; SSF57424; LDL receptor-like module; 1.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 3.
DR PROSITE; PS01209; LDLRA_1; 1.
DR PROSITE; PS50068; LDLRA_2; 1.
DR PROSITE; PS00279; MACPF_1; 1.
DR PROSITE; PS51412; MACPF_2; 1.
DR PROSITE; PS50923; SUSHI; 2.
DR PROSITE; PS50092; TSP1; 3.
PE 3: Inferred from homology;
KW Complement pathway {ECO:0000256|ARBA:ARBA00022875};
KW Cytolysis {ECO:0000256|ARBA:ARBA00022852};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00302}; EGF-like domain {ECO:0000256|ARBA:ARBA00022536};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Membrane attack complex {ECO:0000256|ARBA:ARBA00023058};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Sushi {ECO:0000256|ARBA:ARBA00022659, ECO:0000256|PROSITE-
KW ProRule:PRU00302}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..934
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017187656"
FT DOMAIN 177..521
FT /note="MACPF"
FT /evidence="ECO:0000259|PROSITE:PS51412"
FT DOMAIN 640..699
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 700..763
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT REGION 253..274
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 254..274
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 147..165
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 159..174
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 670..697
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 702..745
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
SQ SEQUENCE 934 AA; 104833 MW; F394621BE0FE01BF CRC64;
MSPSNSLVLL LQLLSCVSVG LACFCDRYPW TSWSPCTQTC NHGVQNRRRQ IHYDDYYWKN
SCHQLCDSQD VRACNEQPCH INCALTDYSQ WSPCSSCAKK QYRTRSVETP SQFGGMQCSE
ELSEERPCYP SKECKLPDID CRENFKCDNG RCINSTLRCN KQNDCGDNSD ERDCNAFSIV
CPTKRQPAPG VDLVGNGFDA LAEEPRGAVL DNMFMGENCI IKRPQSTTLY HRVPYNFESF
DIKVGMVEDF STEPQPLHSE SVSTKRSGSS SYSRGEKDFL SVLLYLGRGS GSTVQSNKEA
FEASKKTDSK FFRVHQVLPV SKFKVKEPED VVLSQTFLQF LHDLPLEYNY PRYRDIFQRF
GTHYYSSGSL GGHYDLLYQY SRQELITSGE TEEHVQGCLF KETTWTVILY TEHSSVTRCR
NNRMTEKYSG SYIQSSEKSF SMVKGGQARE AAALAWERQG PAPDRTSYKN WAKSVLHNPA
VVDYKLRPLI ELVRGIPCAA TKRRHLRKAL LQYLQEFDTC KCAPCPNNAR PVLSGTECKC
VCQTGTFGTN CEKRAPDFTS EAVDGYWSCW GPWSSCGVTM RRSRSRRCDN PSPLKGGEPC
QGPDKQVEPC HVSLFEKQDS CDNDDDFTVG WRDELPPGVK GCLRPQRPPN SFLRIAKPYY
DVGEDEEFRC FTGFELEGFQ FINCRSDGSW SPPSGRCYRN YCDPPQIPDT MTLFPISEAY
KVGESVGLNC KEPGLTPLPQ GFYKCTSSLT WEPPVPADLR CTDVVPVGPG GPCGPGQKQQ
GSRCVCEDRE SCLSEPDALC VLNVDLGFSV SMSLCSFYAG RCHGDPLFFV SEGACDPEDS
SKLEQAKFRA QMCSKSSVHT PCGPDTCYDW ETCSATKQCS CKKPRECAGY EGQMFCVRMS
VSQSTLSVNL CQMGLIRCNN RAFEIVSEGA CASR
//
