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Database: UniProt
Entry: H2MMV9_ORYLA
LinkDB: H2MMV9_ORYLA
Original site: H2MMV9_ORYLA 
ID   H2MMV9_ORYLA            Unreviewed;      1350 AA.
AC   H2MMV9;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 2.
DT   24-JAN-2024, entry version 73.
DE   RecName: Full=Receptor protein-tyrosine kinase {ECO:0000256|ARBA:ARBA00011902, ECO:0000256|PIRNR:PIRNR000619};
DE            EC=2.7.10.1 {ECO:0000256|ARBA:ARBA00011902, ECO:0000256|PIRNR:PIRNR000619};
GN   Name=erbb4 {ECO:0000313|Ensembl:ENSORLP00000020055.2};
OS   Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC   Oryzias.
OX   NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000020055.2, ECO:0000313|Proteomes:UP000001038};
RN   [1] {ECO:0000313|Ensembl:ENSORLP00000020055.2, ECO:0000313|Proteomes:UP000001038}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000020055.2,
RC   ECO:0000313|Proteomes:UP000001038};
RX   PubMed=17554307; DOI=10.1038/nature05846;
RA   Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA   Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA   Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA   Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA   Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA   Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT   "The medaka draft genome and insights into vertebrate genome evolution.";
RL   Nature 447:714-719(2007).
RN   [2] {ECO:0000313|Ensembl:ENSORLP00000020055.2}
RP   IDENTIFICATION.
RC   STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000020055.2};
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC         [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC         COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC         ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1;
CC         Evidence={ECO:0000256|ARBA:ARBA00001171};
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC       pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein
CC       kinase family. EGF receptor subfamily. {ECO:0000256|PIRNR:PIRNR000619}.
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DR   Ensembl; ENSORLT00000020056.2; ENSORLP00000020055.2; ENSORLG00000016023.2.
DR   eggNOG; KOG1025; Eukaryota.
DR   GeneTree; ENSGT00940000154695; -.
DR   TreeFam; TF106002; -.
DR   Proteomes; UP000001038; Chromosome 21.
DR   Bgee; ENSORLG00000016023; Expressed in animal zygote and 5 other cell types or tissues.
DR   GO; GO:0098590; C:plasma membrane region; IEA:UniProt.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0038127; P:ERBB signaling pathway; IEA:UniProt.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   GO; GO:0042127; P:regulation of cell population proliferation; IEA:UniProt.
DR   CDD; cd00064; FU; 3.
DR   CDD; cd12092; TM_ErbB4; 1.
DR   Gene3D; 6.10.250.2930; -; 1.
DR   Gene3D; 3.80.20.20; Receptor L-domain; 2.
DR   Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR   InterPro; IPR044912; Egfr_JX_dom.
DR   InterPro; IPR006211; Furin-like_Cys-rich_dom.
DR   InterPro; IPR006212; Furin_repeat.
DR   InterPro; IPR032778; GF_recep_IV.
DR   InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR000494; Rcpt_L-dom.
DR   InterPro; IPR036941; Rcpt_L-dom_sf.
DR   InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR   InterPro; IPR049328; TM_ErbB1.
DR   InterPro; IPR008266; Tyr_kinase_AS.
DR   InterPro; IPR020635; Tyr_kinase_cat_dom.
DR   InterPro; IPR016245; Tyr_kinase_EGF/ERB/XmrK_rcpt.
DR   PANTHER; PTHR24416:SF90; RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4; 1.
DR   PANTHER; PTHR24416; TYROSINE-PROTEIN KINASE RECEPTOR; 1.
DR   Pfam; PF00757; Furin-like; 1.
DR   Pfam; PF14843; GF_recep_IV; 1.
DR   Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR   Pfam; PF01030; Recep_L_domain; 2.
DR   Pfam; PF21314; TM_ErbB1; 1.
DR   PIRSF; PIRSF000619; TyrPK_EGF-R; 1.
DR   PRINTS; PR00109; TYRKINASE.
DR   SMART; SM00261; FU; 5.
DR   SMART; SM00219; TyrKc; 1.
DR   SUPFAM; SSF57184; Growth factor receptor domain; 2.
DR   SUPFAM; SSF52058; L domain-like; 2.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PIRNR:PIRNR000619};
KW   Kinase {ECO:0000256|PIRNR:PIRNR000619};
KW   Membrane {ECO:0000256|PIRNR:PIRNR000619, ECO:0000256|SAM:Phobius};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW   ECO:0000256|PIRNR:PIRNR000619};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Receptor {ECO:0000256|PIRNR:PIRNR000619};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transferase {ECO:0000256|PIRNR:PIRNR000619};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Tyrosine-protein kinase {ECO:0000256|ARBA:ARBA00023137,
KW   ECO:0000256|PIRNR:PIRNR000619}.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           22..1350
FT                   /note="Receptor protein-tyrosine kinase"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5017183555"
FT   TRANSMEM        637..660
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          703..970
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
FT   REGION          1054..1097
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1237..1263
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1066..1093
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        828
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000619-1"
FT   BINDING         709..717
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000619-2"
FT   BINDING         736
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000619-2,
FT                   ECO:0000256|PROSITE-ProRule:PRU10141"
SQ   SEQUENCE   1350 AA;  150356 MW;  F23A291462532579 CRC64;
     MKPTTVLCCF SFLLLLGFGS SQSVCTGTEN KLSTLSDLEQ QYRTLRKYYE NCEVVMGNLE
     ITSIDRSRNL TFLRSIREVT GYVLVALNQF DHLPLENLRI IRGTKLYEDR YSLAIFLNYR
     RDGNFGLRHL GLINLAEILY GGVYVDQNKF LCHADTIHWQ DIVKNPGFHP VVVPTNSSVT
     CPKCHRSCNG RCWGPKDNQC QSLTKTVCAE QCDGRCSGPY VSDCCHRECA GGCFGPKDTD
     CFACTNFNDS GACVTQCPQP FFYNPTTFQL EHNPSARYTY GAFCVKKCPH NFVVDHNSCV
     RACPTNKMEV EDNHIKMCIP CTDICPKACD GIGTGTLQAA QTVDSSNIDK FVNCTKINGN
     LVFLITGIKG DVYHNIEALD PEKLNVFRSV REITGYLNIQ SWPDNMTDLI VFSNLATIGG
     RALYSGISLL VLKQQGISSF LLQSLKEISA GNVHIAENKQ LCYYNTVNWT RLFRSPNQKV
     LVRNNRNPLE CARGHMVCDP LCSDDGCWGS GPDQCLSCKF FSRGRSCIKS CNLYQGEIRE
     YANGSVCVEC DSQCEQGDDN TLTCHGSGPE HCVKCLHFKD GPNCVEKCPD GLQGASSFIF
     KYAEANNECH PCHPNCTQGC IGPRLQDCIG WMDRTPLIAA GVIGGLFMVV IMALSVAVSV
     RRKNIKKKRA LRRFLETELV EPLTPSGTAP NQAQLRILKE TELKRIKILG SGAFGTVYKG
     IWIPEGETVK IPVAIKILNE TTGPKANVEF MDEALIMASM EHPHLVRLLG VCLSPTIQLV
     TQLMPHGCLL DYVHEHKDNI GSQLLLNWCV QIAKGMMYLE ERRLVHRDLA ARNVLVKSPN
     HVKITDFGLA RLLDVNEKEY NADGGKMPIK WMALECIHYR KFTHQSDVWS YGVTIWELMT
     FGGKPYDGIS TRDIPDLLEK GERLPQPPIC TIDVYMVMVK CWMIDADSRP RFKELAAEFT
     RMARDPQRYL VIQGDDRMKL PSPNDSKFFQ SLLEEEELED LMDAEEYLVP HSFNIPPLAY
     TPHSRMDSSK TQFNCQDPGE LASGAQLSSR FAHVGQDDPR CNGTLRRQAS PRSSKIIAGS
     TLTAGQGGAE DSSAQRYSAD PIGALAERGA KDKDKDGFIA AMRDKNTSDY PHPVEENPFV
     ARRRNGDAHV TFDGASCHTL HLARAAAAPK SQPSFGDEYV NEPLYLNTFL NPGDKNRLAV
     ASLISGSTPS SVQSLQQTVN PSTSSHKVSS AGYVVTPGHL PHPSYPSHTL HPGHSGKAPH
     SDVTSNTIMF EKKGKKTTFD NPEYWQHSLP PKSSLHNPEY LQDCSTRFFY RQNGRIRPAV
     AENQEYLSEA AMKAGNVLPP PPYRQRNTVV
//
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