GenomeNet

Database: UniProt
Entry: H2MPK0_ORYLA
LinkDB: H2MPK0_ORYLA
Original site: H2MPK0_ORYLA 
ID   H2MPK0_ORYLA            Unreviewed;       772 AA.
AC   H2MPK0;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 2.
DT   27-MAR-2024, entry version 80.
DE   SubName: Full=Ral guanine nucleotide dissociation stimulator-like 1 {ECO:0000313|Ensembl:ENSORLP00000020662.2};
GN   Name=rgl1 {ECO:0000313|Ensembl:ENSORLP00000020662.2};
OS   Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC   Oryzias.
OX   NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000020662.2, ECO:0000313|Proteomes:UP000001038};
RN   [1] {ECO:0000313|Ensembl:ENSORLP00000020662.2, ECO:0000313|Proteomes:UP000001038}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000020662.2,
RC   ECO:0000313|Proteomes:UP000001038};
RX   PubMed=17554307; DOI=10.1038/nature05846;
RA   Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA   Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA   Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA   Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA   Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA   Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT   "The medaka draft genome and insights into vertebrate genome evolution.";
RL   Nature 447:714-719(2007).
RN   [2] {ECO:0000313|Ensembl:ENSORLP00000020662.2}
RP   IDENTIFICATION.
RC   STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000020662.2};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; H2MPK0; -.
DR   STRING; 8090.ENSORLP00000020662; -.
DR   Ensembl; ENSORLT00000020663.2; ENSORLP00000020662.2; ENSORLG00000016496.2.
DR   eggNOG; KOG3629; Eukaryota.
DR   GeneTree; ENSGT00940000156012; -.
DR   HOGENOM; CLU_010252_0_1_1; -.
DR   InParanoid; H2MPK0; -.
DR   TreeFam; TF315204; -.
DR   Proteomes; UP000001038; Chromosome 4.
DR   Bgee; ENSORLG00000016496; Expressed in mesonephros and 14 other cell types or tissues.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IBA:GO_Central.
DR   GO; GO:0007265; P:Ras protein signal transduction; IBA:GO_Central.
DR   CDD; cd17210; RA_RGL; 1.
DR   CDD; cd00155; RasGEF; 1.
DR   CDD; cd06224; REM; 1.
DR   Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR   Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR   InterPro; IPR000159; RA_dom.
DR   InterPro; IPR008937; Ras-like_GEF.
DR   InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR   InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR   InterPro; IPR023578; Ras_GEF_dom_sf.
DR   InterPro; IPR001895; RASGEF_cat_dom.
DR   InterPro; IPR036964; RASGEF_cat_dom_sf.
DR   InterPro; IPR030748; RGL1_RA.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR   PANTHER; PTHR23113:SF199; RAL GUANINE NUCLEOTIDE DISSOCIATION STIMULATOR-LIKE 1; 1.
DR   Pfam; PF00788; RA; 1.
DR   Pfam; PF00617; RasGEF; 1.
DR   Pfam; PF00618; RasGEF_N; 1.
DR   SMART; SM00314; RA; 1.
DR   SMART; SM00147; RasGEF; 1.
DR   SMART; SM00229; RasGEFN; 1.
DR   SUPFAM; SSF48366; Ras GEF; 1.
DR   SUPFAM; SSF54236; Ubiquitin-like; 1.
DR   PROSITE; PS50200; RA; 1.
DR   PROSITE; PS00720; RASGEF; 1.
DR   PROSITE; PS50009; RASGEF_CAT; 1.
DR   PROSITE; PS50212; RASGEF_NTER; 1.
PE   4: Predicted;
KW   Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW   ECO:0000256|PROSITE-ProRule:PRU00168};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001038}.
FT   DOMAIN          71..201
FT                   /note="N-terminal Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50212"
FT   DOMAIN          239..508
FT                   /note="Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50009"
FT   DOMAIN          652..739
FT                   /note="Ras-associating"
FT                   /evidence="ECO:0000259|PROSITE:PS50200"
FT   REGION          499..520
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          536..645
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        536..622
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   772 AA;  85695 MW;  1A6B2D95BDEA0C56 CRC64;
     MRETLTMKFA WKTKMSSVQD WGEEAEEGAI YNVTLKRVQI QQAANKGARW LGAEGDRLPP
     GHTVSQLETC KIRSIRAGTL ERLVETLLTA FGDNDLTYTS IFLSTYRAFA STQTVLQLLL
     DRYGNVEESG PVPEQCQSSE GHGAIRNALA SILRAWLDQC PEDFQEPPDY PCLHRLMGYL
     QRALPGSETL RRAESLLEQL QSQARLEETD GGFHGNSSFC LGEEEEVEIE VQEDFLSFNA
     DLVAEQLTYM DALLFRKVIP HHCLGSIWSQ RDKKDHKHSA PTIRATITQF NAVAACVVST
     VLKHRQLRPH VRARLIQRWI DVAQECRIRK NFSSLRAIVS ALQSNPLYRL KRVWACVHRD
     SMQTFEELSD IFSDHNNYLT SRELLMREGT SKFASLESGA KEHQKRTHKR LQLQKEMGAM
     QGTIPYLGTF LTDLTMLDTA LPDLVEGGLI NFEKRRREFE VIAQIKLLQS ACNSYCLSGD
     AAFLRWFRSQ PQLSEEESYA LSCEVEGPGD SSPTSPKPRK SMVKRLSLLF LGTDSSAASS
     PVRDTPRSPP TGSSGESMDS VSVSSSDSSG PSDNEGLVTP THTSHPNKLA ESSSCTSLHS
     MDTSSSTASV SMTPTSPSLS GPPCTHRRCI SLTPMSPGSP SHAPAYNTQA QDACIIRVSL
     EHGNGNLYKS ILLTSQDKTP AVISRAMAKH NLEGEPEDGY ELVQVISEEK ELLIPDNANV
     FYAMNSTANF DFLLRVRGSG SRAVQLRSRC SSTLPRAQHR SSLSLRLSKV TL
//
DBGET integrated database retrieval system