ID H2MPK0_ORYLA Unreviewed; 772 AA.
AC H2MPK0;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 80.
DE SubName: Full=Ral guanine nucleotide dissociation stimulator-like 1 {ECO:0000313|Ensembl:ENSORLP00000020662.2};
GN Name=rgl1 {ECO:0000313|Ensembl:ENSORLP00000020662.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000020662.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000020662.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000020662.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000020662.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000020662.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; H2MPK0; -.
DR STRING; 8090.ENSORLP00000020662; -.
DR Ensembl; ENSORLT00000020663.2; ENSORLP00000020662.2; ENSORLG00000016496.2.
DR eggNOG; KOG3629; Eukaryota.
DR GeneTree; ENSGT00940000156012; -.
DR HOGENOM; CLU_010252_0_1_1; -.
DR InParanoid; H2MPK0; -.
DR TreeFam; TF315204; -.
DR Proteomes; UP000001038; Chromosome 4.
DR Bgee; ENSORLG00000016496; Expressed in mesonephros and 14 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IBA:GO_Central.
DR GO; GO:0007265; P:Ras protein signal transduction; IBA:GO_Central.
DR CDD; cd17210; RA_RGL; 1.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR030748; RGL1_RA.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF199; RAL GUANINE NUCLEOTIDE DISSOCIATION STIMULATOR-LIKE 1; 1.
DR Pfam; PF00788; RA; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00314; RA; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50200; RA; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038}.
FT DOMAIN 71..201
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 239..508
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT DOMAIN 652..739
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT REGION 499..520
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 536..645
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 536..622
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 772 AA; 85695 MW; 1A6B2D95BDEA0C56 CRC64;
MRETLTMKFA WKTKMSSVQD WGEEAEEGAI YNVTLKRVQI QQAANKGARW LGAEGDRLPP
GHTVSQLETC KIRSIRAGTL ERLVETLLTA FGDNDLTYTS IFLSTYRAFA STQTVLQLLL
DRYGNVEESG PVPEQCQSSE GHGAIRNALA SILRAWLDQC PEDFQEPPDY PCLHRLMGYL
QRALPGSETL RRAESLLEQL QSQARLEETD GGFHGNSSFC LGEEEEVEIE VQEDFLSFNA
DLVAEQLTYM DALLFRKVIP HHCLGSIWSQ RDKKDHKHSA PTIRATITQF NAVAACVVST
VLKHRQLRPH VRARLIQRWI DVAQECRIRK NFSSLRAIVS ALQSNPLYRL KRVWACVHRD
SMQTFEELSD IFSDHNNYLT SRELLMREGT SKFASLESGA KEHQKRTHKR LQLQKEMGAM
QGTIPYLGTF LTDLTMLDTA LPDLVEGGLI NFEKRRREFE VIAQIKLLQS ACNSYCLSGD
AAFLRWFRSQ PQLSEEESYA LSCEVEGPGD SSPTSPKPRK SMVKRLSLLF LGTDSSAASS
PVRDTPRSPP TGSSGESMDS VSVSSSDSSG PSDNEGLVTP THTSHPNKLA ESSSCTSLHS
MDTSSSTASV SMTPTSPSLS GPPCTHRRCI SLTPMSPGSP SHAPAYNTQA QDACIIRVSL
EHGNGNLYKS ILLTSQDKTP AVISRAMAKH NLEGEPEDGY ELVQVISEEK ELLIPDNANV
FYAMNSTANF DFLLRVRGSG SRAVQLRSRC SSTLPRAQHR SSLSLRLSKV TL
//