ID H2MQY8_ORYLA Unreviewed; 1147 AA.
AC H2MQY8;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 83.
DE SubName: Full=Potassium voltage-gated channel subfamily H member 7 {ECO:0000313|Ensembl:ENSORLP00000021162.2};
GN Name=KCNH7 {ECO:0000313|Ensembl:ENSORLP00000021162.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000021162.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000021162.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000021162.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000021162.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000021162.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR AlphaFoldDB; H2MQY8; -.
DR STRING; 8090.ENSORLP00000021162; -.
DR Ensembl; ENSORLT00000021163.2; ENSORLP00000021162.2; ENSORLG00000016915.2.
DR eggNOG; KOG0498; Eukaryota.
DR GeneTree; ENSGT00940000155518; -.
DR HOGENOM; CLU_005746_2_0_1; -.
DR InParanoid; H2MQY8; -.
DR TreeFam; TF313130; -.
DR Proteomes; UP000001038; Chromosome 21.
DR Bgee; ENSORLG00000016915; Expressed in brain and 3 other cell types or tissues.
DR GO; GO:0034702; C:monoatomic ion channel complex; IEA:UniProtKB-KW.
DR GO; GO:0005242; F:inward rectifier potassium channel activity; IBA:GO_Central.
DR GO; GO:0086011; P:membrane repolarization during action potential; IBA:GO_Central.
DR GO; GO:0071805; P:potassium ion transmembrane transport; IBA:GO_Central.
DR GO; GO:0086091; P:regulation of heart rate by cardiac conduction; IBA:GO_Central.
DR GO; GO:0060307; P:regulation of ventricular cardiac muscle cell membrane repolarization; IBA:GO_Central.
DR CDD; cd00038; CAP_ED; 1.
DR CDD; cd00130; PAS; 1.
DR Gene3D; 1.10.1200.260; -; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR Gene3D; 3.30.450.20; PAS domain; 1.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR003938; K_chnl_volt-dep_EAG/ELK/ERG.
DR InterPro; IPR003967; K_chnl_volt-dep_ERG.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR NCBIfam; TIGR00229; sensory_box; 1.
DR PANTHER; PTHR10217:SF466; POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY H MEMBER 7; 1.
DR PANTHER; PTHR10217; VOLTAGE AND LIGAND GATED POTASSIUM CHANNEL; 1.
DR Pfam; PF00027; cNMP_binding; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF13426; PAS_9; 1.
DR PRINTS; PR01463; EAGCHANLFMLY.
DR PRINTS; PR01470; ERGCHANNEL.
DR SMART; SM00100; cNMP; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 1.
PE 4: Predicted;
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium channel {ECO:0000256|ARBA:ARBA00022826};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882}.
FT TRANSMEM 408..429
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 545..569
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 610..629
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 641..662
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 742..842
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT REGION 171..213
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 254..278
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 867..915
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1119..1147
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1119..1133
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1147 AA; 128495 MW; BE46DFCE1F7A30AB CRC64;
MPVRRGHVAP QNTFLGLIIR KFEGQNRKFI IANARVENCA IIYCNDGFCE MTGFSRPDIM
QRPCTCDFLH GDLTDKDAIK QVTQAVLGSE ERKVEITYHR KDGSDFQCST HIIPVKNEEG
VVMMFIMNFE HVVDEGSDNS TENISPTSPT RSDLRRSRFF RFRQAALSLM NTNKQSLPQE
DPDAVMVDSP KEDEDSVALD SFPSPTKSVC SPTEVNDTHA LISSSHHCSQ TSIGPEPLDH
SSLKLPWEKL YQTESHQSST SLSNTFPRGS TSSMRRASSI HEIEGYSSNS KSVFGDRQTG
EGPFNHVKSS LLGSTSDSNI NKYSTISKIP LIALNFSEVT DKKTHSPQTS EKTIIAPKVK
DRTHNVTEKV TQVLSLGADV LPEYKLQTPR IDKFTILHYS PFKAVWDWLI LLLVIYTAIL
TPYSAAFLLN DQEEQKRREC GYSCSPLNVV DLMVDIMFII DILINFRTTY VNQNEEVVSH
PAKIAIHYFK GWFLIDMVAA IPFDLLIFGS GSDETTTLIG LLKTARLLRL VRVARKLDRY
SEYGAAVLML LMCIFALIAH WLACIWYAIG NVEKPYLDHK IGWLDNLGVS IGKRYNYSDP
NSGPSIKDKY VTALYFTFSS LTSVGFGNVS PNTNSEKIFS ICVMLIGSLM YASIFGNVSA
IIQRLYSGTA RYHAQMLRVK EFIRFHQIPN PLRQRLEEYF QHSWTYTNGI DLNTEVLKGF
PECLQADICL HLNRNLLNDC NAFQGATKGC LRALAMRFRT THAPPGDTLV HSGDVLTALY
FLSRGSIEIL KDDIVVAILG KNDIFGEMFH LYAKPGKSNA DVRALSYCDL CTIQREDLLE
VLDMYPEFAD YFFNNLELTF NLRDEPTKPC DDEECEPDGE ANKPIKRRIS FTPGLPKEMD
EGDQKRRGSS SCLKRSSVVL GSSSLSVPAL DTELTHRDGL EVTPSVEDLQ SDKWACKKPA
DYLDESAHFQ DLREYENSAS EVTYGEVEQR LGQLQDHLNR LESQLISDIQ SILQMLQRQS
TPGPPAYSTV TASLDYHRPA VKVQPAVQTA SSFFSHTATQ GPSQKLESTI QESKDSVCSS
AVVSAPPDGS LAAFFEQRHT DPQQQTALIP LPAESSSSFF CSATPSDPDH NVIGQQRPVS
EPEFPRL
//
