GenomeNet

Database: UniProt
Entry: H2MR34_ORYLA
LinkDB: H2MR34_ORYLA
Original site: H2MR34_ORYLA 
ID   H2MR34_ORYLA            Unreviewed;      1672 AA.
AC   H2MR34;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   10-MAY-2017, entry version 42.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
OS   Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae;
OC   Oryziinae; Oryzias.
OX   NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000021210, ECO:0000313|Proteomes:UP000001038};
RN   [1] {ECO:0000313|Proteomes:UP000001038}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hd-rR {ECO:0000313|Proteomes:UP000001038};
RX   PubMed=17554307; DOI=10.1038/nature05846;
RA   Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B.,
RA   Yamada T., Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D.,
RA   Shimada A., Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A.,
RA   Asakawa S., Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K.,
RA   Sugano S., Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F.,
RA   Nomoto H., Nogata K., Morishita T., Endo T., Shin-I T., Takeda H.,
RA   Morishita S., Kohara Y.;
RT   "The medaka draft genome and insights into vertebrate genome
RT   evolution.";
RL   Nature 447:714-719(2007).
RN   [2] {ECO:0000313|Ensembl:ENSORLP00000021210}
RP   IDENTIFICATION.
RC   STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000021210};
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSORLP00000021210}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; BAAF04019150; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BAAF04019151; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BAAF04019152; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BAAF04019153; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BAAF04019154; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BAAF04019155; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 8090.ENSORLP00000021210; -.
DR   Ensembl; ENSORLT00000021211; ENSORLP00000021210; ENSORLG00000016955.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   InParanoid; H2MR34; -.
DR   OMA; NGVPNHT; -.
DR   OrthoDB; EOG091G01WJ; -.
DR   TreeFam; TF323985; -.
DR   Proteomes; UP000001038; Chromosome 21.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:Ensembl.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR024583; Na_trans_cytopl.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   Pfam; PF11933; Na_trans_cytopl; 1.
DR   PRINTS; PR00170; NACHANNEL.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001038};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM     22     43       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM     49     69       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    185    212       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    523    540       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    560    582       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    588    608       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    629    662       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    686    706       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    718    741       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    968    986       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1007   1026       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1082   1110       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1205   1228       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1287   1304       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1316   1335       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1347   1367       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1404   1432       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1508   1531       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN        8    217       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      293    472       Na_trans_cytopl. {ECO:0000259|Pfam:
FT                                PF11933}.
FT   DOMAIN      523    745       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      755    962       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN      966   1236       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1286   1541       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED      209    254       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1672 AA;  190331 MW;  BC513CAA87E790C7 CRC64;
     YLNEFADFGR LSALRTFRVL RAFKAISVIP GLKTIVGALF QSVKKLTDVM ILTVFCLSVF
     ALVGLQLFMG HLKNKCVRQP EHVTPEKNEK ISSRQQFCGW KCLVDAIGNH YFLSGKRDPL
     LCGNSTYAGK CPEGYTCVSF GSTPDFGYTS FDSFGWAFLA LFRLMTQDFW ENLYQQTLRA
     SGKPYMIFFV LVIFLGSFYL INLILAVVAM AYEEQSQTNI KEAKEKEEEF QAMLEELKQQ
     QEEVQMQAQT TKTKTIKAIA NTAESKDPGD KGDGTGGTSN LTSKSAKERC NMKKKKKEEE
     RKEVSEIPKS NSLNSLKKEI SHLTTDGNLL NSDLKSSTTH QSFLNFRGAL ISSRRYSKTS
     LFSFQSQIQD LSSENEFADD EYSIFEENRS GSGSMSHHLH DRHSSSPDGL KHSSIGCNGC
     MSQKDRSSPP VGFLLSKVAL ELQYRRPSAA YSDLMDYLEG PEARQRAQSL VSVITSTVEE
     LEESRKKCPP CWYKFAENFL IWDCCPAWQK IKKFVKLIVM DPFADLTITI CIVLNTLFMA
     MEHHPMQDEF TKMLSIGNKV FTGIFTAEMV LKIIALDPYY YFQERWNIFD GIIVTISLVE
     LCFSINLLRS LRLLRVFKLA KSWPTLNSLL KIIGNSVGAM GNLTLVLAII VFIFAVVGMQ
     LFEREYRYNV SKISADRKPR WHMMDFFHSF LIVFRVLCGE WIETMWDCME VAGVTKCLIV
     YMMVMVVGNL VMLNLFLALL LSSFSADNLA AIEEDSDLNN LQIAIKRICR GFDFIKSFLK
     NICNSNCHKE KKEKTKDKSL GEFKKPFGTN DLHNHTLKNF HTNSNVNLTG VDKSGDKYIV
     NSKSNDSIMS FINNPSLTVT VPIAAVESDF EVLNTEDFSS ASSDVQPCRV DEDEELSSSE
     GSTINDYEAG EIADSVGGEL EESNDPSPCF PAVCLQNIKC CQVNVDVGFW KAWWKLRQTC
     FRIVEHSWFE SFIIFMILLS SGALAFEDVY SEQRKTIKII LEFADKMFTY IFILEMLLKW
     LAYGFAKYFT NAWCWLDFLI VDVSLVSLVA NALELTDLGA IKSLRTLRAL RPLRALSRFE
     GMRVVVNALL GAIPSIFNVL LVCLIFWLIF SIMGVNLFAG KFYKCINKTD GVECDPENIP
     NKTFCTNETD LIWKNLKINY DNVGMGYLAL LQVATFKGWM DIMYAAVDSG EPDEQPVFER
     NIKMYLYFVV FIIFGSFFTL NLFIGVIIDN FNQQKKKFGG TDLFMTEDQK KYYNAMKKLG
     SKKPQKPIPR PSNKIQGFIF DIISKQAFDI VIMVLIWLNM VTMMVETADQ SEKQTYILRV
     INYVFIVIFS GECLLKMIGL RHYFFMNGWN IFDLVVVILS IAGVFLAKII EDYFVSPTLF
     RVIRLARIGR VLRLIKSAKG IRTLLFALMM SLPALFNIGL LLFLVMFIYA IFGMSSFAYV
     KKDKGIDDLF NFETFGNSMI CLFQITTSGG WDTLLDPILN SNIDDCDRNK EHPGSNTKGD
     CGNPPVGIAF FVSYIIISFL IVVNMYIAVI LENFNVATEE STDPLSEDDF EMFYEVWERF
     DPGATQFIHY YSLSDFADAL NPPLQVPKPN RIDLIFMDLP IVSGDRIHCL DILFAFTKRV
     LGEGGEMDIL REQMEERFMA SNPSKVSYEP ITTTLRRKEE LRSATVIQRA FR
//
DBGET integrated database retrieval system