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Database: UniProt
Entry: H2MR69_ORYLA
LinkDB: H2MR69_ORYLA
Original site: H2MR69_ORYLA 
ID   H2MR69_ORYLA            Unreviewed;      1494 AA.
AC   H2MR69;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   25-OCT-2017, entry version 39.
DE   RecName: Full=Voltage-dependent L-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
OS   Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae;
OC   Oryziinae; Oryzias.
OX   NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000021248, ECO:0000313|Proteomes:UP000001038};
RN   [1] {ECO:0000313|Proteomes:UP000001038}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hd-rR {ECO:0000313|Proteomes:UP000001038};
RX   PubMed=17554307; DOI=10.1038/nature05846;
RA   Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B.,
RA   Yamada T., Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D.,
RA   Shimada A., Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A.,
RA   Asakawa S., Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K.,
RA   Sugano S., Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F.,
RA   Nomoto H., Nogata K., Morishita T., Endo T., Shin-I T., Takeda H.,
RA   Morishita S., Kohara Y.;
RT   "The medaka draft genome and insights into vertebrate genome
RT   evolution.";
RL   Nature 447:714-719(2007).
RN   [2] {ECO:0000313|Ensembl:ENSORLP00000021248}
RP   IDENTIFICATION.
RC   STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000021248};
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. The isoform alpha-1C
CC       gives rise to L-type calcium currents. Long-lasting (L-type)
CC       calcium channels belong to the 'high-voltage activated' (HVA)
CC       group. They are blocked by dihydropyridines (DHP),
CC       phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA
CC       (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-
CC       GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA).
CC       Calcium channels containing the alpha-1C subunit play an important
CC       role in excitation-contraction coupling in the heart. Binding of
CC       calmodulin or CABP1 at the same regulatory sites results in an
CC       opposit effects on the channel function.
CC       {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSORLP00000021248}.
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DR   EMBL; BAAF04096929; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BAAF04096930; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BAAF04096931; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BAAF04096932; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BAAF04096933; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BAAF04096934; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BAAF04096935; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BAAF04096936; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BAAF04096937; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BAAF04096938; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 8090.ENSORLP00000021248; -.
DR   Ensembl; ENSORLT00000021249; ENSORLP00000021248; ENSORLG00000016984.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128247; -.
DR   OMA; TILVEME; -.
DR   OrthoDB; EOG091G0TKO; -.
DR   TreeFam; TF312805; -.
DR   Proteomes; UP000001038; Chromosome 7.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0008331; F:high voltage-gated calcium channel activity; IEA:InterPro.
DR   GO; GO:0050856; P:regulation of T cell receptor signaling pathway; IEA:InterPro.
DR   GO; GO:0043029; P:T cell homeostasis; IEA:InterPro.
DR   GO; GO:0007601; P:visual perception; IEA:InterPro.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR014873; VDCC_a1su_IQ.
DR   InterPro; IPR030157; VDCC_L_a1F.
DR   InterPro; IPR005446; VDCC_L_a1su.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   PANTHER; PTHR10037:SF184; PTHR10037:SF184; 2.
DR   Pfam; PF08763; Ca_chan_IQ; 1.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 3.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01630; LVDCCALPHA1.
DR   SMART; SM01062; Ca_chan_IQ; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001038};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM     27     46       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     66     85       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     97    114       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    175    198       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    254    275       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    287    309       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    402    421       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    560    580       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    601    619       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    839    859       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    880    913       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1005   1031       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1085   1103       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1115   1135       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1218   1236       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1310   1333       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1467   1494       Ca_chan_IQ. {ECO:0000259|SMART:SM01062}.
SQ   SEQUENCE   1494 AA;  171935 MW;  9BF179EAAD075783 CRC64;
     RAPRALFCLK LNNPIRRAAL SIVEWKPFDI FILLAIFANC VALGVSKPFP EDDSNSTNHD
     LEQVEYVFLI IFTVETFLKI LAYGLVMHPS SYIRNGWNLL DFVIVIVGLF SVVLETMTHK
     SSGEQATTHH MPGKPGGLDV KALRAFRVLR PLRLVSGVPS LQIVLNSIMK AMVPLLHIAL
     LVLFVIIIYA IIGLELFIGR MHRTCYYIIT DNFVEDEPVP CAFAGHGRQC IINGTECRGG
     WDGPNGGITN FDNFFFAMLT VFQCITMEGW TDVLYWMNDA IGFELPWVYF VSLVIFGSFF
     VLNLVLGVLS GEFSKEREKA KARGDFQKLR EKQQMEEDLC GYMDWITQAE DMDDLDEDGN
     PTSETASENT ENIDEEHTNC CQACCRTLRR WNRICRRNCR TAVKSVTFYW LVLLLVFLNT
     SLSASEHYDQ PEWLTQVQVV SSTVILLSFK LIQLNPFEES GEQWMTYIER FEHFVLANGI
     EDAKKVPVLL SVMGPKTVTL VGCVRVKASQ KLQRNKNRIN KSLKNKVRKK AYKLCLLLKI
     SLSYSFTTCS KWGGDFSCDA YIYITYPIFS TFNELLLLVT NKTMTFLFLS TIIADNFYIK
     PGIGVYKLLV IICWIYTVLR IVRWTSCENH AHRLLLERSS KAKVKISLRP AQQKTCTEKR
     EDERKLLGNK SHFQKSKGNV KKTNKRSLVF KMFFFNRAAI EDPYWLNTPD PGNQQQQLPS
     VPMTTTQKHV AQLMLDAKTF ISVWTIKTHL EKLTNQTSSS NHLCSMIPTF SDFLLCFIFL
     HKLILCSETT LMPYNYCNYC INLIDIVQIT ILLTSETNIK KTKYFPLLIL CVLKHNLTVP
     LRILIFFLGS SAISVVKILR VLRVLRPLRA INRAKGLKHV VQCVFVAIRT IGNIMIVTTL
     LQFMFACIGV QLFKGKFYRC TDEAKSTPEQ CKGTFVVYKD GDVTHPMVRQ RIWLNSDFNF
     DNVLMGMMAL FTVSTFEGWP ALLYKAIDAN GENSGPIYNY RVEISIFFIV YIIIIAFFMM
     NIFVGFVIIT FREQGEQEYK NCELDKNQRQ CVEYALKAQP LKLYIPKNPV QYKFWSIINS
     TGFEYVMFVL ILLNTVTLAV QHYEQSKTFS YIMDILNMVF TGLFTAEMLL KLLALRPRHY
     FVDPWNSFDA LIVVGSVVDI VVTEFSTEHV ISFQSGEDSS RVSITFFRLF RVMRLVKLLS
     KGEGIRTLLW TFIKSLQALP YVALLIAMIF FIYAVIGMQT FGKIAMQDYT QINRNNNFQT
     FPQAVLLLFR CATGEAWQEI MLASLPGKRC DPESDYEPGE EFSCGSNFAI VYFISFFMLC
     AFLIINLFVA VIMDNFDYLT RDWSILGPHH LDEFKRIWSE YDPEAKGRIK HLDVVALLRR
     IQPPLGFGKL CPHRVACKRL VAMNMPLNAD GMVTFNATLF ALVRTALKIK TDGHPEQENE
     ELRAIIRKIW KRMKPKLLDE VIPPHEEEEV TVGKFYATFL IQDYFRKFRK RKEK
//
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