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Database: UniProt
Entry: H2MSC8_ORYLA
LinkDB: H2MSC8_ORYLA
Original site: H2MSC8_ORYLA 
ID   H2MSC8_ORYLA            Unreviewed;      2354 AA.
AC   H2MSC8;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   25-OCT-2017, entry version 43.
DE   SubName: Full=Calcium voltage-gated channel subunit alpha1 E {ECO:0000313|Ensembl:ENSORLP00000021665};
GN   Name=CACNA1E (1 of many) {ECO:0000313|Ensembl:ENSORLP00000021665};
OS   Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae;
OC   Oryziinae; Oryzias.
OX   NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000021665, ECO:0000313|Proteomes:UP000001038};
RN   [1] {ECO:0000313|Proteomes:UP000001038}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hd-rR {ECO:0000313|Proteomes:UP000001038};
RX   PubMed=17554307; DOI=10.1038/nature05846;
RA   Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B.,
RA   Yamada T., Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D.,
RA   Shimada A., Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A.,
RA   Asakawa S., Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K.,
RA   Sugano S., Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F.,
RA   Nomoto H., Nogata K., Morishita T., Endo T., Shin-I T., Takeda H.,
RA   Morishita S., Kohara Y.;
RT   "The medaka draft genome and insights into vertebrate genome
RT   evolution.";
RL   Nature 447:714-719(2007).
RN   [2] {ECO:0000313|Ensembl:ENSORLP00000021665}
RP   IDENTIFICATION.
RC   STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000021665};
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSORLP00000021665}.
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DR   EMBL; BAAF04082746; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BAAF04082747; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BAAF04082748; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BAAF04082749; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BAAF04082750; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BAAF04082751; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BAAF04082752; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BAAF04082753; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BAAF04082754; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BAAF04082755; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 8090.ENSORLP00000021665; -.
DR   Ensembl; ENSORLT00000021666; ENSORLP00000021665; ENSORLG00000017305.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; COG1226; LUCA.
DR   GeneTree; ENSGT00830000128247; -.
DR   InParanoid; H2MSC8; -.
DR   OMA; RRRHHMS; -.
DR   OrthoDB; EOG091G0TKO; -.
DR   TreeFam; TF312805; -.
DR   Proteomes; UP000001038; Chromosome 4.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR014873; VDCC_a1su_IQ.
DR   InterPro; IPR005449; VDCC_R_a1su.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   PANTHER; PTHR10037:SF57; PTHR10037:SF57; 3.
DR   Pfam; PF08763; Ca_chan_IQ; 1.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   SMART; SM01062; Ca_chan_IQ; 1.
DR   PROSITE; PS50222; EF_HAND_2; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001038};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM     92    109       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    130    151       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    163    183       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    222    244       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    295    316       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    328    350       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    504    523       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    535    555       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    630    652       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    707    729       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1158   1176       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1225   1243       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1289   1311       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1401   1426       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1482   1501       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1513   1535       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1541   1559       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1603   1621       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1700   1723       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1739   1774       EF-hand. {ECO:0000259|PROSITE:PS50222}.
SQ   SEQUENCE   2354 AA;  265466 MW;  918EEE2C2D37B5DA CRC64;
     MARFGDEVPG LLSSGDGGSE RNRNRDGAAV STGGISPAFK QTKAQRARTM ALYNPIPVRE
     NCFTVNRSLF IFGEDNVVRK YAKKITEWPY PFEYMILTTI IANCIVLALE QHLPGEDKTP
     MSKKLEKTEP YFIGMFCLEA GIKIIALGFV FHKGSYLRNG WNVMDFIVVL SGILAAAGAH
     LNISVDLRTL RAVRVLRPLK LVSGIPSLQI VLKSIMKAMV PLLQIGLLLF FAILMFAIIG
     LEFYSGKLHK TCTQNETVDS SEYEFPCGVR QCPSGYTCNR PWIGPNDGIT QFDNILFAVL
     TVFQCITMEG WTTVLYNTND ALGPTWNWLY FIPLIIIGSF FVLNLVLGVL SGEFAKERER
     VENRRAFMKL RRQQQIEREL NGYRAWIDKA EEVMLAEENK NPGPSALDGI TAHRKKPPKQ
     QNVCLPELRS GGADVLKRAT TIKRRGMDVR QGHPGEELYG DISSVGMPTA RISIRSGKRG
     PAAYFRRKER LLRISIRRVV KTHTFYWTVL GLVALNTLCV AIVHHNQPLW LSNSLYYAEF
     LFLALFLTEM FLKMYSLGPR LYFHSSFNCF DCSVIVGSIF EVLWGFFRPG TSFGISVLRA
     LRLLRIFKIT KYWASLRNLV VSLMNSMKSI ISLIFLLFLF ILVFALLGMQ LFGGRFIFED
     YTPTNFDTFP AAIMTVFQIL TGEDWNEVMY NGIRSQGGVK SGMWSSVYFI VLTLFGNYTL
     LNVFLAIAVD NLANAQELTK DEEEAEAAFN QKHAMQKAKE VGPLSSFMSS EVKVPRRERR
     KRMTMSVWEQ RTSQLRRHRQ MSSREILFTS PGEEKDALVQ GPHEHPLSLH RKAMQHTPSG
     GVKGSTDAQA SPTKNQVTSA GVSVDVALEA SLPDDRPEPA TSLLEPEPPD PPAGSGLIPD
     GNKLGVNHKA DHECRSPRLN AERQHRAVKK FRPPDNTESG GRVEIRGRRT ALLCDHEQGT
     NDQSTGCPTG GRRRNQDQEE ESAECERKEG EEPKEEEHRR SENISQNYST AVVHSFKDVS
     NEKKDSEIRR CDQSKGGEPM PQEIQSHSSD PTSQTQEEPP PAPNVSPPAN PGDTEVGQGQ
     DTHPLSSSVM IEVPNMQSSL ELSTISVNSK DPERCKSEKE EEEDEVKPAS TVRPDSMFIF
     KPDNPVRRAC HYVVNLRYFE MSILLVIAAS SIALAAEDPV ATTSDWNKVL RYFDYVFTGV
     FTFEMIIKMI DQGLILHDGS YFRDLWNILD FIVVVGALVA FALTNNKGRD IKTIKSLRVL
     RVLRPLKTIK RLPKLKAVFD CVVTSLKNVF NILIVYKLFM FIFAVIAVQL FKGKFFYCTD
     SSKGLEKDCQ GYYIDYGKDK KEMKKREWKR HEFHYDNVVW ALLTLFTVST GEGWPQVLQH
     SVDVTEEDRG PSHGNRMEMS IFYVIYFVVF PFFFVNIFVA LIIITFQEQG DKMMEECSLE
     KNERACIDFA ISAKPLTRYM PQNRHTFQYR LWHFVVSPSF EYTVLTMIAL NTIVLMMKYY
     SAPPAYDAVL KHLNTAFTVL FSIECVLKIL AFGFLNYFRD TWNIFDFITV LGSITEIVVD
     LQRIDTFNMS FLKLFRAARL IKLLRQGYTI RILLWTFVQS FKALPYVCLL IAMLFFIYAI
     IGMQVFGNIK LNEETQINQH NNFKTFSGAL MLLFRSATGE SWQEIMLSCL GGQPCETDSS
     IQTAEGTSDH REGCGSDFAY FYFVSFIFFS SFLMLNLFVA VIMDNFEYLT RDSSILGPHH
     LDEFVRIWGE YDRAASGRIH YKEMYKVVRT ISPPLGFGKN CPHRVACKRL VLMNMPVDDD
     MSVHFTSTLM ALIRTALEIK IARGGEDRNQ MDLDLQKEIG VIWPHLSQKA LDLLVPIHKA
     SDMTIGKIYA AMMIMDYYKQ NKAKKLRQQL EEQVKGVIKS TYYNMIEKSK ESRKNTQKGE
     CIIAKTFLCD STPMFVFAGS TKGALNNPIK SAAAGGSEST RSVFYFKHAP MFQRMDASSL
     PQVPEVVQYN QLMQQTLSKS PQRTASVRAS SMPRLAIDPQ KFSSSPGSSI ALIADTKSMK
     RSFSTIGDQC VNGLWQEQHS LERISPDAAY RPRQRSFRGG ERERRTIHES LYQTEDGAIL
     SLSGHSGQEA SSHERGRSKE RRHLLSPDVS REPSHERSRS PSEGRTNNAK KPAKQPRPPS
     PLSSEQGACG PPSVIASVSP VNSASETGTP RNRRQLPQTP SRPRPHISYS PLVCRASTSP
     TAPAPTEEQS LPPDGPSDST ETPWRTDKDS RPLSAGQSSP EGGGSAPSHS SPHRYTSEPH
     LPFHKESSPA ERQETLTFET AIATTLGRTH AISSAPQLRH SWQVPNGHFR KPLAQANPAD
     GSELLSDTDE DDLC
//
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