ID H2MTN8_ORYLA Unreviewed; 444 AA.
AC H2MTN8;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=Transcription factor AP-2 beta {ECO:0000313|Ensembl:ENSORLP00000022144.2};
GN Name=tfap2b {ECO:0000313|Ensembl:ENSORLP00000022144.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000022144.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000022144.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000022144.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000022144.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000022144.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the AP-2 family.
CC {ECO:0000256|ARBA:ARBA00007770}.
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DR AlphaFoldDB; H2MTN8; -.
DR STRING; 8090.ENSORLP00000022144; -.
DR Ensembl; ENSORLT00000022145.2; ENSORLP00000022144.2; ENSORLG00000017695.2.
DR eggNOG; KOG3811; Eukaryota.
DR GeneTree; ENSGT00950000182848; -.
DR HOGENOM; CLU_035175_0_0_1; -.
DR InParanoid; H2MTN8; -.
DR OrthoDB; 2883153at2759; -.
DR TreeFam; TF313718; -.
DR Proteomes; UP000001038; Chromosome 24.
DR Bgee; ENSORLG00000017695; Expressed in brain and 4 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0048856; P:anatomical structure development; IBA:GO_Central.
DR GO; GO:0042127; P:regulation of cell population proliferation; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR004979; TF_AP2.
DR InterPro; IPR008122; TF_AP2_beta.
DR InterPro; IPR013854; TF_AP2_C.
DR PANTHER; PTHR10812; TRANSCRIPTION FACTOR AP-2; 1.
DR PANTHER; PTHR10812:SF14; TRANSCRIPTION FACTOR AP-2-BETA; 1.
DR Pfam; PF03299; TF_AP-2; 1.
DR PRINTS; PR01750; AP2BTNSCPFCT.
DR PRINTS; PR01748; AP2TNSCPFCT.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000001038}.
FT DOMAIN 217..411
FT /note="Transcription factor AP-2 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03299"
FT REGION 19..133
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 422..444
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 51..65
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 70..99
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 444 AA; 48432 MW; 6DAE19B711A29DE2 CRC64;
MLWKLVENVK YEDIYEDRHD GVSSHSSRLS QLGSVAHGGP YSSAPPLSHA PSSDFQPPYF
PPPYQPLAHY QSQDPYSHVS DPYSLNSLHQ SQQGAWGARQ RQDASGERMD GSSLLAQPRA
SLPQLSGLDP RRDYGVRRPD VLLHSTHPGL EPGMGDSLLH GLHGMDEVQA IDESNGTNIL
DQSVIKKVPM PPKNVGSLML GKDGLIGGVS VNINEVFCSV PGRLSLLSST SKYKVTVGEV
QRRLSPPECL NASLLGGVLR RAKSKNGGKC LREKLEKIGL NLPAGRRKAA NVTLLTSLVE
GEAVHLARDF GYICETEFPT KAVSEYLNRQ HADPSELHTR KNMLLATKQL CKEFTDLLAQ
DRTPLGNSRP TPILEPGIQS CLSHFSFITH GFGSPAICAA LTALQNYLTE ALKGLDKMFL
NNPSNNRHGD AGKAAGDKEE KQRK
//
