ID H2N2B9_ORYLA Unreviewed; 668 AA.
AC H2N2B9;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=Nucleoporin NDC1 {ECO:0000256|ARBA:ARBA00017534};
DE AltName: Full=Transmembrane protein 48 {ECO:0000256|ARBA:ARBA00031201};
GN Name=ndc1 {ECO:0000313|Ensembl:ENSORLP00000025598.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000025598.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000025598.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000025598.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000025598.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000025598.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Component of the nuclear pore complex (NPC), which plays a
CC key role in de novo assembly and insertion of NPC in the nuclear
CC envelope. Required for NPC and nuclear envelope assembly, possibly by
CC forming a link between the nuclear envelope membrane and soluble
CC nucleoporins, thereby anchoring the NPC in the membrane.
CC {ECO:0000256|ARBA:ARBA00025441}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Nucleus membrane
CC {ECO:0000256|ARBA:ARBA00004232}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004232}. Nucleus, nuclear pore complex
CC {ECO:0000256|ARBA:ARBA00004567}.
CC -!- SIMILARITY: Belongs to the NDC1 family.
CC {ECO:0000256|ARBA:ARBA00005760}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_004086746.1; XM_004086698.2.
DR AlphaFoldDB; H2N2B9; -.
DR STRING; 8090.ENSORLP00000025598; -.
DR Ensembl; ENSORLT00000025599.2; ENSORLP00000025598.2; ENSORLG00000020666.2.
DR GeneID; 101169920; -.
DR KEGG; ola:101169920; -.
DR CTD; 55706; -.
DR GeneTree; ENSGT00390000014590; -.
DR HOGENOM; CLU_027343_0_0_1; -.
DR InParanoid; H2N2B9; -.
DR OrthoDB; 2906257at2759; -.
DR Proteomes; UP000001038; Chromosome 17.
DR Bgee; ENSORLG00000020666; Expressed in ovary and 14 other cell types or tissues.
DR GO; GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070762; C:nuclear pore transmembrane ring; IBA:GO_Central.
DR GO; GO:0030674; F:protein-macromolecule adaptor activity; IBA:GO_Central.
DR GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR GO; GO:0006999; P:nuclear pore organization; IBA:GO_Central.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR InterPro; IPR019049; Nucleoporin_prot_Ndc1/Nup.
DR PANTHER; PTHR13269:SF6; NUCLEOPORIN NDC1; 1.
DR PANTHER; PTHR13269; UNCHARACTERIZED; 1.
DR Pfam; PF09531; Ndc1_Nup; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW mRNA transport {ECO:0000256|ARBA:ARBA00022816};
KW Nuclear pore complex {ECO:0000256|ARBA:ARBA00023132};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Translocation {ECO:0000256|ARBA:ARBA00023010};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 19..40
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 52..81
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 108..130
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 262..286
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 382..408
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 428..508
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 382..406
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 428..456
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 479..494
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 668 AA; 73938 MW; 869CC0A1AC92D752 CRC64;
MFAADSGCWF TQKVLCWRAA ASVAWSVLLL PASTAAFVVL SKLSVLHPVQ MFADCVSVLL
SAGSVFSFVL LAGVIIMVGF LTFEYYTVIP SIACSKVALL GQLLHPRQLL YCLAHGVMGV
VVGWSCAVTI GYRYERLAYL CPQKDRDGLL HMCLNEHHLL LLLEGGFVGL SHSLLGVIQN
LNYVSFGTVQ QHKYLCFKAS LPLAAKCSAA QAFYSVRNFV LLYFFLGHIP RAWMCKSLSL
HLDSSAHPLD SISGLLDLSL LYLLWISATY LLFSWYMTLL LFRIFVTEAY SFPVQSTFTE
EAPQCLPKVL SEKQPMILKF LALQDLSLLS QHSPSRRSQV FSLSQPGGHP HNWNAISKEC
LSLLADLTQR LVSYHETVAT NGRTKSLSSG SDRKTSSESS GTEDLASCRP TFLMKTPASV
FLRSVGAGPQ SPLTSPFTPD LDSPFASPTL RQLTSPVDPG SPWHGVVQSP HVMRRAPKLW
STSTDSQRNG SPPASPATLP TPKPESSKPS FLAQFFQNRR EQVKHFMAKR MLVMYLFTKL
PEASSQALFA DGQAHIWALD GLSYLVQASF TEDQFGVVQT TLPSILSSML LLQEAVDRHF
KLPHASSKPV RSTISLGDSS HKTLRFALRA TLKTAIYRIT TTFGAHLHAV QLSAEHRKRL
QHFLEYKE
//