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Database: UniProt
Entry: H2N7T6_PONAB
LinkDB: H2N7T6_PONAB
Original site: H2N7T6_PONAB 
ID   H2N7T6_PONAB            Unreviewed;       576 AA.
AC   H2N7T6;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   30-AUG-2017, entry version 33.
DE   SubName: Full=Potassium voltage-gated channel subfamily Q member 4 {ECO:0000313|Ensembl:ENSPPYP00000001714};
GN   Name=KCNQ4 {ECO:0000313|Ensembl:ENSPPYP00000001714};
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Pongo.
OX   NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000001714, ECO:0000313|Proteomes:UP000001595};
RN   [1] {ECO:0000313|Ensembl:ENSPPYP00000001714, ECO:0000313|Proteomes:UP000001595}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Wilson R.K., Mardis E.;
RT   "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
RL   Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSPPYP00000001714}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the potassium channel family.
CC       {ECO:0000256|SAAS:SAAS00692852}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSPPYP00000001714}.
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DR   EMBL; ABGA01315736; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABGA01315737; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABGA01315738; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABGA01315739; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABGA01315740; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABGA01315741; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9601.ENSPPYP00000001714; -.
DR   Ensembl; ENSPPYT00000001770; ENSPPYP00000001714; ENSPPYG00000001482.
DR   eggNOG; KOG1419; Eukaryota.
DR   eggNOG; COG1226; LUCA.
DR   GeneTree; ENSGT00550000074513; -.
DR   InParanoid; H2N7T6; -.
DR   OrthoDB; EOG091G02ZT; -.
DR   TreeFam; TF315186; -.
DR   Proteomes; UP000001595; Chromosome 1.
DR   GO; GO:0008076; C:voltage-gated potassium channel complex; IEA:InterPro.
DR   GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:Ensembl.
DR   GO; GO:0042472; P:inner ear morphogenesis; IEA:Ensembl.
DR   GO; GO:0007605; P:sensory perception of sound; IEA:Ensembl.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR003937; K_chnl_volt-dep_KCNQ.
DR   InterPro; IPR013821; K_chnl_volt-dep_KCNQ_C.
DR   InterPro; IPR015573; KCQN4.
DR   InterPro; IPR028325; VG_K_chnl.
DR   PANTHER; PTHR11537; PTHR11537; 1.
DR   PANTHER; PTHR11537:SF214; PTHR11537:SF214; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF03520; KCNQ_channel; 2.
DR   PRINTS; PR00169; KCHANNEL.
DR   PRINTS; PR01459; KCNQCHANNEL.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001595};
KW   Ion channel {ECO:0000256|SAAS:SAAS00417203};
KW   Ion transport {ECO:0000256|SAAS:SAAS00417186};
KW   Membrane {ECO:0000256|SAAS:SAAS00788393, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|SAAS:SAAS00417282};
KW   Potassium channel {ECO:0000256|SAAS:SAAS00417246};
KW   Potassium transport {ECO:0000256|SAAS:SAAS00417240};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001595};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00793138,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00789957,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|SAAS:SAAS00417268}.
FT   TRANSMEM     99    121       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    133    153       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    174    199       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    239    258       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    270    287       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    299    324       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      100    324       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      430    464       KCNQ_channel. {ECO:0000259|Pfam:PF03520}.
FT   DOMAIN      462    527       KCNQ_channel. {ECO:0000259|Pfam:PF03520}.
SQ   SEQUENCE   576 AA;  63432 MW;  5FEA3B0509D7FE53 CRC64;
     MAEAPPRSLG LGPPPGDAPR AELVALTAVQ SEQGEAGGGG SPRRLGLLGS PLPPGAPLPG
     PGSGSGSACG QRSSAAHKRY RRLQNWVYNV LERPRGWAFV YHVFIFLLVF SCLVLSVLST
     IQEHQELANE CLLILEFVMI VVFGLEYIVR VWSAGCCCRY RGWQGRFRFA RKPFCVIDFI
     VFVASVAVIA AGTQGNIFAT SALRSMRFLQ ILRMVRMDRR GGTWKLLGSV VYAHSKELIT
     AWYIGFLVLI FASFLVYLAE KDANSDFSSY ADSLWWGTIT LTTIGYGDKT PHTWLGRVLA
     AGFALLGISF FALPAGILGS GFALKVQEQH RQKHFEKRRM PAANLIQAAW RLYSTDMSRA
     YLTATWYYYD SILPSFRELA LLFEHVQRAR NGGLRPLEVR RAPVPDGAPS RYPPVATCHR
     PGSTSFCPGE APSEEAAEEK SYQCELTVDD VMPAVKTVIR SIRVDQIVGR GPGDRKAREK
     GDKGPSDAEV VDEISMMGRV VKVEKQVQSI EHKLDLLLGF YSRCLRSGTS ASLGAVQVPL
     FDPDITSDYH SPVDHEDISV SAQTLSISRS VSTNMD
//
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