ID H2N8F9_PONAB Unreviewed; 1981 AA.
AC H2N8F9;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 2.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=Crystallin beta-gamma domain containing 2 {ECO:0000313|Ensembl:ENSPPYP00000001948.2};
GN Name=CRYBG2 {ECO:0000313|Ensembl:ENSPPYP00000001948.2};
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000001948.2, ECO:0000313|Proteomes:UP000001595};
RN [1] {ECO:0000313|Ensembl:ENSPPYP00000001948.2, ECO:0000313|Proteomes:UP000001595}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Wilson R.K., Mardis E.;
RT "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPPYP00000001948.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the beta/gamma-crystallin family.
CC {ECO:0000256|ARBA:ARBA00009646}.
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DR AlphaFoldDB; H2N8F9; -.
DR Ensembl; ENSPPYT00000002009.2; ENSPPYP00000001948.2; ENSPPYG00000001686.2.
DR eggNOG; ENOG502R2J7; Eukaryota.
DR GeneTree; ENSGT00940000157740; -.
DR HOGENOM; CLU_002147_2_1_1; -.
DR InParanoid; H2N8F9; -.
DR OMA; CVWYYED; -.
DR TreeFam; TF331078; -.
DR Proteomes; UP000001595; Chromosome 1.
DR GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR Gene3D; 2.80.10.50; -; 1.
DR Gene3D; 2.60.20.10; Crystallins; 6.
DR InterPro; IPR001064; Beta/gamma_crystallin.
DR InterPro; IPR011024; G_crystallin-like.
DR InterPro; IPR035992; Ricin_B-like_lectins.
DR PANTHER; PTHR11818; BETA/GAMMA CRYSTALLIN; 1.
DR PANTHER; PTHR11818:SF2; BETA_GAMMA CRYSTALLIN DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF00030; Crystall; 6.
DR PRINTS; PR01367; BGCRYSTALLIN.
DR SMART; SM00247; XTALbg; 6.
DR SUPFAM; SSF49695; gamma-Crystallin-like; 3.
DR SUPFAM; SSF50370; Ricin B-like lectins; 1.
DR PROSITE; PS50915; CRYSTALLIN_BETA_GAMMA; 7.
DR PROSITE; PS50231; RICIN_B_LECTIN; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000001595};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 1344..1387
FT /note="Beta/gamma crystallin 'Greek key'"
FT /evidence="ECO:0000259|PROSITE:PS50915"
FT DOMAIN 1434..1476
FT /note="Beta/gamma crystallin 'Greek key'"
FT /evidence="ECO:0000259|PROSITE:PS50915"
FT DOMAIN 1488..1533
FT /note="Beta/gamma crystallin 'Greek key'"
FT /evidence="ECO:0000259|PROSITE:PS50915"
FT DOMAIN 1534..1576
FT /note="Beta/gamma crystallin 'Greek key'"
FT /evidence="ECO:0000259|PROSITE:PS50915"
FT DOMAIN 1623..1665
FT /note="Beta/gamma crystallin 'Greek key'"
FT /evidence="ECO:0000259|PROSITE:PS50915"
FT DOMAIN 1714..1757
FT /note="Beta/gamma crystallin 'Greek key'"
FT /evidence="ECO:0000259|PROSITE:PS50915"
FT DOMAIN 1804..1845
FT /note="Beta/gamma crystallin 'Greek key'"
FT /evidence="ECO:0000259|PROSITE:PS50915"
FT REGION 23..45
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 129..214
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 231..330
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 392..493
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 564..589
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 601..643
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 657..699
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 734..1080
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1127..1191
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1203..1223
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 23..44
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 147..161
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 239..253
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 276..298
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 392..416
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 424..444
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 603..617
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 657..683
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 759..778
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 799..813
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 825..846
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 881..895
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 954..969
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 987..1019
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1050..1067
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1144..1158
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1159..1177
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1981 AA; 211812 MW; AB055563A07624C4 CRC64;
MAERCGGPGA CLARLLAGLG VRREHSGKET SEATSRDRPR DGRSCSDLAQ GTTCNVSLKA
QGQSCSEWDI HVGGHGDFWI WKQQGISGGP AQSLGRLQRP AVGSTFDLAS HASLGPESLA
LEVASGEPAR ARLPPYPGPA PGHGEQGSSG CTCQQSPPTA SEVPLRAEPP SNLEDAPLLP
RLASFPRAEG TKGKPATPGT ALPEPAQTLH MCPSSRRTRY YITVTLLGHR QAPGEEGEEP
AQPAPPPCGP EESEGWWEPP QGPRPITGCR TAPPQEPQLR AQSHQGSTAQ QQKLQAGWTP
GSPRRLELDH SGTRTPPDRL PGPHMEEAGG PTAQAKARVV SATLTWRQRP PAQEEIKHGF
HKVSLVSGAQ MEVPQKEMFE FSRREEVNGF ATQEEETVNC QGPRDTAGSK NFQSHGPIFS
KKYIPPPKEK RPEGRLKEAV DQSDGSRQAP RTEPPRVGAM ARTELLVPLP GPREPSPHPG
VGLTSGSSRS LEEYRVTRTV RTATVVGGHV DRRVSSSVTV RPVSSGEALP RGRQVARMVP
PVVVGSPPGS PSRGQAVKVL SNLVPAGHSP PASHLPRPTA DRPRSTGLGS TVRAALRQLP
ETRTAQLKDS SALASTGIPA SAPLPKNQDA PAACPDRDQG RAPDARACEL QQVLGAPSST
ELPLQTSQGQ ASVPSSPRLQ THVPSPGLTH PAKQPVVPTH PRAQLTPFVL PPIKREGLVD
PPAATVLPMV RSEHVTVPGQ PPAPSSTRRK DVPSPGGLSA PSSPRNKFVQ NSENVPVLPF
TQREVVKGPG APAASSPTRK EVVQGSSAPA ASSPTWKEVV KGPSAPAASS STQEVVQGSS
APAASSPIQK EVVKGPSAPD ASFPTWKEVV KGPGAPAASS PTQKEVVQGS GAPTALSTAP
KEVVKGPGAP AASSPTQKEV VKGPCAPAAS SPTQKEVVQG SGAPAALSPK STEVVQGPEG
STSIQKEAVQ GIAGSLAPPL TKEETVQGPT APATSLPKQD KGVQDSEGSP ISSLTQKEVV
QDPAALPAPS SSVDRASPSP GGTPAPVPTG AEASTESQLV SDPTEGKTCP ETSREEDEVA
LATDLEIFLD TLRSMEPPEI LRTHRLPRAP RSSYLSMYAT LPAIEEDQPG PWVLGPGPQE
VPSLEEKEEE EEEPENPYLS DDEKLQRRQE KAGPSPSRDL HPARPTQVSC SPLEMMKKHV
AGTKGPHSEL GLELQGGSRP TSRLGGSLLF GSLVPATKEA STPEPLGTKL SALLPHGAPG
LRKVPGQLPL LCSERPSPTE KLACSLPLEG WSPALKTQGK PNTRPGKVIF FSESGCQGSG
REVWGDIVDA SGWAPVASIR VVRGCWVLYE EPEFRGQKLV LPEGDVELRT PGTKWSPQGI
GSLRRVVWDY STPEISLFSE EGLKGEQVKL TEALKNSQGL EKPLQVASAT VSAGLWLLYP
KPLFEDTPYI LEPGEYPTSE AWGTSDPSVG SLKPMRLGCP SVEKPGEPRA VVYEAPGFQG
RSWEVSRDIY NLQQPEDSQS PHLASVGSLR VLGGCWVGYE KEGFRGHQYL LEEGEYPDWS
HWGGYDELLT SLRVIRTDFG DPAVVLFEAM DFEGHGVEVS KALPDVELVQ HGPSTQAIHV
LSGVWVAYQE VGFSGEQYVL EKGVYRNCED WGAGNSALAS LQPVLQVGEH DLHFVSKIQL
FSRPDFLGEH FSFEDDQVAL PASFRPQSCR VHGGSWILFD EKNFEGDQHI LSEGEFPTLT
AMGCLASTVL GSLQKVSLHF SEPSIFLYGL ECFEGKEIEL SREVRSLQAE GFNNHVLSVR
IKGGVWVLCE HSDFRGRQWL VGSCEITNWL TYSGTQRVGS LYPIKQRRVY FRLWNAALGG
FLAVPDHVED MKAGRVVVSD PRAGGSCIWY YEDGMLKNQM APTMSLQVIG PPSSGSKVVL
WAESRLPRQT WSISESGHIC SQMFEGQILD VKGGRGYDRD HVVLWEPDED RASQIWTIHV
L
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