ID   H2NGL6_PONAB            Unreviewed;       299 AA.
AC   H2NGL6;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   25-MAY-2022, sequence version 2.
DT   27-MAR-2024, entry version 51.
DE   RecName: Full=Taste receptor type 2 {ECO:0000256|RuleBase:RU004424};
GN   Name=TAS2R19 {ECO:0000313|Ensembl:ENSPPYP00000004907.2};
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000004907.2, ECO:0000313|Proteomes:UP000001595};
RN   [1] {ECO:0000313|Ensembl:ENSPPYP00000004907.2, ECO:0000313|Proteomes:UP000001595}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Wilson R.K., Mardis E.;
RT   "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
RL   Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSPPYP00000004907.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC       ECO:0000256|RuleBase:RU004424}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU004424}.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor T2R family.
CC       {ECO:0000256|ARBA:ARBA00007376, ECO:0000256|RuleBase:RU004423}.
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DR   AlphaFoldDB; H2NGL6; -.
DR   Ensembl; ENSPPYT00000005100.2; ENSPPYP00000004907.2; ENSPPYG00000038226.1.
DR   eggNOG; ENOG502TE6U; Eukaryota.
DR   GeneTree; ENSGT01100000263477; -.
DR   HOGENOM; CLU_072337_2_0_1; -.
DR   InParanoid; H2NGL6; -.
DR   OMA; YERNITQ; -.
DR   TreeFam; TF335891; -.
DR   Proteomes; UP000001595; Chromosome 12.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR   GO; GO:0033038; F:bitter taste receptor activity; IEA:InterPro.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   CDD; cd15027; 7tm_TAS2R43-like; 1.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR007960; TAS2R.
DR   PANTHER; PTHR11394; TASTE RECEPTOR TYPE 2; 1.
DR   PANTHER; PTHR11394:SF139; TASTE RECEPTOR TYPE 2 MEMBER 19-RELATED; 1.
DR   Pfam; PF05296; TAS2R; 1.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
PE   3: Inferred from homology;
KW   G-protein coupled receptor {ECO:0000256|RuleBase:RU004424};
KW   Membrane {ECO:0000256|RuleBase:RU004424, ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000256|RuleBase:RU004424};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001595};
KW   Sensory transduction {ECO:0000256|ARBA:ARBA00022606,
KW   ECO:0000256|RuleBase:RU004424};
KW   Taste {ECO:0000256|ARBA:ARBA00022480, ECO:0000256|RuleBase:RU004424};
KW   Transducer {ECO:0000256|RuleBase:RU004424};
KW   Transmembrane {ECO:0000256|RuleBase:RU004424, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        6..35
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        47..67
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        87..108
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        128..149
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        185..206
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        227..248
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        260..281
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   299 AA;  33951 MW;  A024996DD16DE7D7 CRC64;
     VICFLLIISS ILVVFAFDFG NVANGFIALV NVIDWVKTQK ISSADQILTA LVVSRIGLLW
     VMLSLWYATV FNSALYGFEV KIVASNAWAV TNHFSMWLAA NLSIFYLLKI ANFSNLIFLH
     LKKRIKSVVL VVVLGPLVFL ICNLAVITMD DSVWTKEYEG NVTWKIKLRN AIHLSNLTVT
     TLANLIPFTL SLICFLLLIC SLCKHLKKMR LHSKGSQDPS TKFHIKALQT VTSFLVLFTI
     YFLCIITSTW NRRTQQSKLV LLLCQIIAIM YPSFHSFILI MGSRKLKQTF LSVLWQMTC
//