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Database: UniProt
Entry: H2NJ26_PONAB
LinkDB: H2NJ26_PONAB
Original site: H2NJ26_PONAB 
ID   H2NJ26_PONAB            Unreviewed;       856 AA.
AC   H2NJ26;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   27-SEP-2017, entry version 28.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   Name=ATP6V0A2 {ECO:0000313|Ensembl:ENSPPYP00000005803};
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Pongo.
OX   NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000005803, ECO:0000313|Proteomes:UP000001595};
RN   [1] {ECO:0000313|Ensembl:ENSPPYP00000005803, ECO:0000313|Proteomes:UP000001595}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Wilson R.K., Mardis E.;
RT   "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
RL   Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSPPYP00000005803}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSPPYP00000005803}.
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DR   EMBL; ABGA01364041; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABGA01364042; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABGA01364043; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABGA01364044; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABGA01364045; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_003778203.1; XM_003778155.2.
DR   STRING; 9601.ENSPPYP00000005803; -.
DR   Ensembl; ENSPPYT00000006024; ENSPPYP00000005803; ENSPPYG00000005095.
DR   GeneID; 100939293; -.
DR   KEGG; pon:100939293; -.
DR   CTD; 23545; -.
DR   eggNOG; KOG2189; Eukaryota.
DR   eggNOG; COG1269; LUCA.
DR   GeneTree; ENSGT00390000004941; -.
DR   InParanoid; H2NJ26; -.
DR   KO; K02154; -.
DR   OMA; TIPSFMN; -.
DR   OrthoDB; EOG091G01BI; -.
DR   TreeFam; TF300346; -.
DR   Proteomes; UP000001595; Chromosome 12.
DR   GO; GO:0001669; C:acrosomal vesicle; IEA:Ensembl.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005765; C:lysosomal membrane; IEA:Ensembl.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   GO; GO:0006879; P:cellular iron ion homeostasis; IEA:Ensembl.
DR   GO; GO:0036295; P:cellular response to increased oxygen levels; IEA:Ensembl.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001595};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001595};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    406    430       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    451    468       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    554    572       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    584    607       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    647    666       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    786    808       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED       94    128       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   856 AA;  98125 MW;  16D2A41CEC6C7190 CRC64;
     MGSLFRSETM CLAQLFLQSG TAYECLSALG EKGLVQFRDL NQNISSFQRK FVGEVKRCEE
     LERILVYLVQ EINRADIPLP EGEASPPAPP LKQVLEMQEQ LQKLEVELRE VTKNKEKLRK
     NLLELIEYTH MLRVTKTFVK RNVEFEPTYE EFPSLESDSL LDYSCMQRLG AKLGFVSGLI
     NQGKVEAFEK MLWRVCKGYT IVSYAELDES LEDPETGEVI KWYVFLISFW GEQIGHKVKK
     ICDCYHCHVY PYPNTAEERR EIQEGLNTRI QDLYTVLHKT EDYLRQVLCK AAESVYSRVI
     QVKKMKAIYH MLNMCSFDVT NKCLIAEVWC PEADLQDLRW ALEEGSRESG ATIPSFMNII
     PTKETPPTRI RTNKFTEGFQ NIVDAYGVGS YREVNPALFT IITFPFLFAV MFGDFGHGFV
     MFLFALLLVL NENHPRLNQS QEIMRMFFNG RYILLLMGLF SVYTGLIYND CFSKSVNLFG
     SGWNVSAMYS SSHPPAEHKK MVLWNDSVVR HNSILQLDPS VPGVFRGPYP LGIDPIWNLA
     TNRLTFLNSF KMKMSVILGI IHMTFGVILG IFNHLHFRKK FNIYLVSIPE LLFMLCIFGY
     LIFMIFYKWL VFSAETSRVA PSILIEFINM FLFPASKTNG LYTGQEYVQR VLLVVTALSV
     PVLFLGKPLF LLWLHNGRSC FGVNRSGYTL IRKDSEEEVS LLGSQDVEEG NHQVEDGCRE
     MACEEFNFGE ILMTQVIHSI EYCLGCISNT ASYLRLWALS LAHAQLSDVL WAMLMRVGLR
     VDTTYGVLLL LPVIALFAVL TIFILLIMEG LSAFLHAIRL HWVEFQNKFY VGAGTKFVPF
     SFSLLSSKFN NDDSVA
//
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