ID H2NJ76_PONAB Unreviewed; 939 AA.
AC H2NJ76; A0A2J8RAN5;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 2.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=ANKLE2 isoform 1 {ECO:0000313|EMBL:PNJ05593.1};
DE SubName: Full=Ankyrin repeat and LEM domain containing 2 {ECO:0000313|Ensembl:ENSPPYP00000005864.2};
GN Name=ANKLE2 {ECO:0000313|Ensembl:ENSPPYP00000005864.2};
GN ORFNames=CR201_G0052314 {ECO:0000313|EMBL:PNJ05593.1};
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000005864.2, ECO:0000313|Proteomes:UP000001595};
RN [1] {ECO:0000313|Ensembl:ENSPPYP00000005864.2, ECO:0000313|Proteomes:UP000001595}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Wilson R.K., Mardis E.;
RT "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:PNJ05593.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Susie {ECO:0000313|EMBL:PNJ05593.1};
RA Pollen A., Hastie A., Hormozdiari F., Dougherty M., Liu R., Chaisson M.,
RA Hoppe E., Hill C., Pang A., Hillier L., Baker C., Armstrong J.,
RA Shendure J., Paten B., Wilson R., Chao H., Schneider V., Ventura M.,
RA Kronenberg Z., Murali S., Gordon D., Cantsilieris S., Munson K., Nelson B.,
RA Raja A., Underwood J., Diekhans M., Fiddes I., Haussler D., Eichler E.;
RT "High-resolution comparative analysis of great ape genomes.";
RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSPPYP00000005864.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the ANKLE2 family.
CC {ECO:0000256|ARBA:ARBA00007597}.
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DR EMBL; NDHI03003721; PNJ05593.1; -; Genomic_DNA.
DR STRING; 9601.ENSPPYP00000005864; -.
DR Ensembl; ENSPPYT00000006091.2; ENSPPYP00000005864.2; ENSPPYG00000005147.3.
DR eggNOG; ENOG502QQ4Z; Eukaryota.
DR GeneTree; ENSGT00390000016767; -.
DR HOGENOM; CLU_017564_0_0_1; -.
DR OMA; DLGCPHS; -.
DR OrthoDB; 5402020at2759; -.
DR TreeFam; TF317729; -.
DR Proteomes; UP000001595; Chromosome 12.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:Ensembl.
DR GO; GO:0051721; F:protein phosphatase 2A binding; IEA:Ensembl.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0007417; P:central nervous system development; IEA:Ensembl.
DR GO; GO:0007084; P:mitotic nuclear membrane reassembly; IEA:Ensembl.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
DR GO; GO:0042326; P:negative regulation of phosphorylation; IEA:Ensembl.
DR GO; GO:0035307; P:positive regulation of protein dephosphorylation; IEA:Ensembl.
DR CDD; cd12944; LEM_ANKL2; 1.
DR Gene3D; 1.10.720.40; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 3.40.970.10; Ribonuclease H1, N-terminal domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR011015; LEM/LEM-like_dom_sf.
DR InterPro; IPR035006; LEM_ANKL2.
DR InterPro; IPR003887; LEM_dom.
DR InterPro; IPR011320; RNase_H1_N.
DR InterPro; IPR037056; RNase_H1_N_sf.
DR PANTHER; PTHR12349; ANKYRIN REPEAT AND LEM DOMAIN-CONTAINING PROTEIN 2; 1.
DR PANTHER; PTHR12349:SF4; ANKYRIN REPEAT AND LEM DOMAIN-CONTAINING PROTEIN 2; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF01693; Cauli_VI; 1.
DR Pfam; PF03020; LEM; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF63451; LEM domain; 1.
DR PROSITE; PS50954; LEM; 1.
PE 3: Inferred from homology;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043};
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Cell division {ECO:0000256|ARBA:ARBA00022618};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001595};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..32
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 69..113
FT /note="LEM"
FT /evidence="ECO:0000259|PROSITE:PS50954"
FT REGION 690..727
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 872..925
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 890..904
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 939 AA; 104104 MW; DE54C6B74C2F65B8 CRC64;
MLWPRLAAAE WAALAWELLG ASVLLIAVRW LVRRLGPRPG GLGRSGTPVP PPSAAAAPAP
GEMTMDAVLA RLKLLKPDDL REEIIKAGLK CGPITSTTRF IFEKKLAQAL LEQGGRLPSF
DHHEAGVTAL SQDPQRILKP AEGNPTDQAG FSEDREFGYS VGLNPPEEEA VTSKTCSVAP
SATDTYRAGV TASKEPPLYY GVCPVYEDIP VRNERIYVYE NKKEALQAVK MIKGSRFKAF
STREDAEKFA RGICDYFPSP SKTSLPLSPV KTAPLFSNDG LKDGLCLSES ETVNKERANS
YKNPRTQDLT AKLRKAVEKG EEDTFSDLIW SNPRYLIGSG DNPTIVQEGC RYNVMHVAAK
ENQASICQLT LDVLENPDFM RLMYPDDDEA MLQKRIRYVV DLYLNTPDKM GYDTPLHFAC
KFGNADVVNV LSSHHLIVKN SRNKYDKTPE DVICERSKNK SVELKERIRE YLKGHYYVPL
LRAEDTSSPV IGELWSPDQT AEASHVSRYG GSPRDPVLTL RAFAGPLSPA KAEDFRRLWK
TPPREKAGFL HHVKKSDPER GFERVGRELA HELGYPWVEY WEFLGCFVDL SSQEGLQRLE
EYLTQQEIGK KAQQETGEQK ASCRDKATMS GSNSISVRAF LDEDDMSLEE IKNRQNAARN
NSPPTVGAFG HTRCSAFPLE QEADLIEAAE PGSPHNSRNG LCHPLSHSRT LAGKRPKAPR
GEEAHLPPVS DLTVEFDKLN LQNVGSSVSK TPDENTKTKD KILTSRINAV ERDLLEPPSP
TDQLGNGHRR TESEMSARIA KMSLSPSSPR HEDQLEVTRE PARRLFLFGE EPSKLDQDVL
AALECADVDP HQFPAVHRWK SAVLCYSPSD RQSWPSPAVK GKFKSQLPDL SGPHSYSPGR
NSVAGSNPAK PGLGSPGRYS PVHGSQLRRM ARLAELAAL
//
