ID H2NLW1_PONAB Unreviewed; 785 AA.
AC H2NLW1;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 3.
DT 24-JAN-2024, entry version 52.
DE SubName: Full=Transmembrane protein 63C {ECO:0000313|Ensembl:ENSPPYP00000006845.3};
GN Name=TMEM63C {ECO:0000313|Ensembl:ENSPPYP00000006845.3};
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000006845.3, ECO:0000313|Proteomes:UP000001595};
RN [1] {ECO:0000313|Ensembl:ENSPPYP00000006845.3, ECO:0000313|Proteomes:UP000001595}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Wilson R.K., Mardis E.;
RT "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPPYP00000006845.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the CSC1 (TC 1.A.17) family.
CC {ECO:0000256|ARBA:ARBA00007779}.
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DR AlphaFoldDB; H2NLW1; -.
DR Ensembl; ENSPPYT00000007114.3; ENSPPYP00000006845.3; ENSPPYG00000006018.3.
DR eggNOG; KOG1134; Eukaryota.
DR GeneTree; ENSGT00940000159072; -.
DR HOGENOM; CLU_015647_0_0_1; -.
DR InParanoid; H2NLW1; -.
DR TreeFam; TF324300; -.
DR Proteomes; UP000001595; Chromosome 14.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005227; F:calcium activated cation channel activity; IEA:InterPro.
DR InterPro; IPR045122; Csc1-like.
DR InterPro; IPR003864; CSC1/OSCA1-like_7TM.
DR InterPro; IPR027815; CSC1/OSCA1-like_cyt.
DR InterPro; IPR032880; Csc1/OSCA1-like_N.
DR PANTHER; PTHR13018:SF21; CALCIUM PERMEABLE STRESS-GATED CATION CHANNEL 1; 1.
DR PANTHER; PTHR13018; PROBABLE MEMBRANE PROTEIN DUF221-RELATED; 1.
DR Pfam; PF14703; PHM7_cyt; 1.
DR Pfam; PF02714; RSN1_7TM; 1.
DR Pfam; PF13967; RSN1_TM; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001595};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 35..59
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 139..159
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 193..211
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 406..430
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 450..473
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 494..517
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 606..630
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 651..673
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 685..706
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 42..203
FT /note="CSC1/OSCA1-like N-terminal transmembrane"
FT /evidence="ECO:0000259|Pfam:PF13967"
FT DOMAIN 220..398
FT /note="CSC1/OSCA1-like cytosolic"
FT /evidence="ECO:0000259|Pfam:PF14703"
FT DOMAIN 409..663
FT /note="CSC1/OSCA1-like 7TM region"
FT /evidence="ECO:0000259|Pfam:PF02714"
SQ SEQUENCE 785 AA; 91359 MW; 0F64B0657FB0757B CRC64;
MSASPDDLST GGRLQNMTVD ECFQSRNTVL QGQPFGGVPT VLCLNIVLWV LVLVVYSFLR
KAAWDYGRLA LLIHNDSLTS LIYGEQSEKT SPSETSLEME RRDKGFCSWF FNSITMKDED
LINKCGDDAR IYIVFQYHLI IFVLIICIPS LGIIFPINYT GSVLDWSSHF ARTTIVNVST
ESKLLWLHSL LSFFYFITNF MFMAHHCLGF APRNSQKVTR TLMITYVPKD IEDPELIIKH
FHEAYPGSVV TRVHFCYDVR NLIDLDDQRR HAMRGRLFYT AKAKKTGKVM IRIHPCARLC
FCKCWTCFKE VDAEQYYSEL EEQLTDEFNA ELNRVPLKRL DLIFVTFQDS RMAKRVRKDY
KYVQCGVQPQ QSSVTTIVKS YYWRVTMAPH PKDIIWKHLS VRRFFWWARF IAINTFLFFL
FFFLTTPAII MNTIDMYNVT RPIEKLQSPI VTQFFPSVML WGFTVILPLI VYFSAFLEAH
WTRSSQNLVM VHKCYIFLVF MVIILPSMGL TSLDVFLRWL FDIYYLEQAS IRFQCVFLPD
NGAFFVNYVI TAALLGTGME LLRLGSLFCY STRLFFSRSE PERVNIRKNQ AIDFQFGREY
AWMMNVFSVV MAYSITCPII VPFGLLYLCM KHLTDRYNMY YSFAPTKLNE QIHMAAVSQA
IFAPLLGLFW MLFFSILRLG SLHTITIFSL STLLIAMIIA FVGIFLGKLR MVADYEPEEE
EIQTVFDMEP SSTSSTPTSL VQMLPWPWMK SEKKRRATMH SALSGRHLKR KYLVREAETT
ATSVM
//