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Database: UniProt
Entry: H2NLW1_PONAB
LinkDB: H2NLW1_PONAB
Original site: H2NLW1_PONAB 
ID   H2NLW1_PONAB            Unreviewed;       785 AA.
AC   H2NLW1;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   25-MAY-2022, sequence version 3.
DT   24-JAN-2024, entry version 52.
DE   SubName: Full=Transmembrane protein 63C {ECO:0000313|Ensembl:ENSPPYP00000006845.3};
GN   Name=TMEM63C {ECO:0000313|Ensembl:ENSPPYP00000006845.3};
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000006845.3, ECO:0000313|Proteomes:UP000001595};
RN   [1] {ECO:0000313|Ensembl:ENSPPYP00000006845.3, ECO:0000313|Proteomes:UP000001595}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Wilson R.K., Mardis E.;
RT   "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
RL   Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSPPYP00000006845.3}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the CSC1 (TC 1.A.17) family.
CC       {ECO:0000256|ARBA:ARBA00007779}.
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DR   AlphaFoldDB; H2NLW1; -.
DR   Ensembl; ENSPPYT00000007114.3; ENSPPYP00000006845.3; ENSPPYG00000006018.3.
DR   eggNOG; KOG1134; Eukaryota.
DR   GeneTree; ENSGT00940000159072; -.
DR   HOGENOM; CLU_015647_0_0_1; -.
DR   InParanoid; H2NLW1; -.
DR   TreeFam; TF324300; -.
DR   Proteomes; UP000001595; Chromosome 14.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005227; F:calcium activated cation channel activity; IEA:InterPro.
DR   InterPro; IPR045122; Csc1-like.
DR   InterPro; IPR003864; CSC1/OSCA1-like_7TM.
DR   InterPro; IPR027815; CSC1/OSCA1-like_cyt.
DR   InterPro; IPR032880; Csc1/OSCA1-like_N.
DR   PANTHER; PTHR13018:SF21; CALCIUM PERMEABLE STRESS-GATED CATION CHANNEL 1; 1.
DR   PANTHER; PTHR13018; PROBABLE MEMBRANE PROTEIN DUF221-RELATED; 1.
DR   Pfam; PF14703; PHM7_cyt; 1.
DR   Pfam; PF02714; RSN1_7TM; 1.
DR   Pfam; PF13967; RSN1_TM; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001595};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   TRANSMEM        35..59
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        139..159
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        193..211
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        406..430
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        450..473
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        494..517
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        606..630
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        651..673
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        685..706
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          42..203
FT                   /note="CSC1/OSCA1-like N-terminal transmembrane"
FT                   /evidence="ECO:0000259|Pfam:PF13967"
FT   DOMAIN          220..398
FT                   /note="CSC1/OSCA1-like cytosolic"
FT                   /evidence="ECO:0000259|Pfam:PF14703"
FT   DOMAIN          409..663
FT                   /note="CSC1/OSCA1-like 7TM region"
FT                   /evidence="ECO:0000259|Pfam:PF02714"
SQ   SEQUENCE   785 AA;  91359 MW;  0F64B0657FB0757B CRC64;
     MSASPDDLST GGRLQNMTVD ECFQSRNTVL QGQPFGGVPT VLCLNIVLWV LVLVVYSFLR
     KAAWDYGRLA LLIHNDSLTS LIYGEQSEKT SPSETSLEME RRDKGFCSWF FNSITMKDED
     LINKCGDDAR IYIVFQYHLI IFVLIICIPS LGIIFPINYT GSVLDWSSHF ARTTIVNVST
     ESKLLWLHSL LSFFYFITNF MFMAHHCLGF APRNSQKVTR TLMITYVPKD IEDPELIIKH
     FHEAYPGSVV TRVHFCYDVR NLIDLDDQRR HAMRGRLFYT AKAKKTGKVM IRIHPCARLC
     FCKCWTCFKE VDAEQYYSEL EEQLTDEFNA ELNRVPLKRL DLIFVTFQDS RMAKRVRKDY
     KYVQCGVQPQ QSSVTTIVKS YYWRVTMAPH PKDIIWKHLS VRRFFWWARF IAINTFLFFL
     FFFLTTPAII MNTIDMYNVT RPIEKLQSPI VTQFFPSVML WGFTVILPLI VYFSAFLEAH
     WTRSSQNLVM VHKCYIFLVF MVIILPSMGL TSLDVFLRWL FDIYYLEQAS IRFQCVFLPD
     NGAFFVNYVI TAALLGTGME LLRLGSLFCY STRLFFSRSE PERVNIRKNQ AIDFQFGREY
     AWMMNVFSVV MAYSITCPII VPFGLLYLCM KHLTDRYNMY YSFAPTKLNE QIHMAAVSQA
     IFAPLLGLFW MLFFSILRLG SLHTITIFSL STLLIAMIIA FVGIFLGKLR MVADYEPEEE
     EIQTVFDMEP SSTSSTPTSL VQMLPWPWMK SEKKRRATMH SALSGRHLKR KYLVREAETT
     ATSVM
//
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