ID H2NPZ4_PONAB Unreviewed; 1112 AA.
AC H2NPZ4; A0A2J8S7H8;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 2.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=NLR family CARD domain containing 3 {ECO:0000313|Ensembl:ENSPPYP00000007971.2};
DE SubName: Full=NLRC3 isoform 4 {ECO:0000313|EMBL:PNJ16737.1};
GN Name=NLRC3 {ECO:0000313|Ensembl:ENSPPYP00000007971.2};
GN ORFNames=CR201_G0045571 {ECO:0000313|EMBL:PNJ16737.1};
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000007971.2, ECO:0000313|Proteomes:UP000001595};
RN [1] {ECO:0000313|Ensembl:ENSPPYP00000007971.2, ECO:0000313|Proteomes:UP000001595}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Wilson R.K., Mardis E.;
RT "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:PNJ16737.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Susie {ECO:0000313|EMBL:PNJ16737.1};
RA Pollen A., Hastie A., Hormozdiari F., Dougherty M., Liu R., Chaisson M.,
RA Hoppe E., Hill C., Pang A., Hillier L., Baker C., Armstrong J.,
RA Shendure J., Paten B., Wilson R., Chao H., Schneider V., Ventura M.,
RA Kronenberg Z., Murali S., Gordon D., Cantsilieris S., Munson K., Nelson B.,
RA Raja A., Underwood J., Diekhans M., Fiddes I., Haussler D., Eichler E.;
RT "High-resolution comparative analysis of great ape genomes.";
RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSPPYP00000007971.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; NDHI03003602; PNJ16737.1; -; Genomic_DNA.
DR STRING; 9601.ENSPPYP00000007971; -.
DR Ensembl; ENSPPYT00000008302.2; ENSPPYP00000007971.2; ENSPPYG00000007048.2.
DR eggNOG; KOG4308; Eukaryota.
DR GeneTree; ENSGT00940000159861; -.
DR HOGENOM; CLU_002274_3_0_1; -.
DR OMA; DFTQVET; -.
DR TreeFam; TF329403; -.
DR Proteomes; UP000001595; Chromosome 16.
DR GO; GO:0034451; C:centriolar satellite; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IEA:Ensembl.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
DR GO; GO:0007249; P:canonical NF-kappaB signal transduction; IEA:Ensembl.
DR GO; GO:0043124; P:negative regulation of canonical NF-kappaB signal transduction; IEA:Ensembl.
DR GO; GO:0050728; P:negative regulation of inflammatory response; IEA:Ensembl.
DR GO; GO:0032715; P:negative regulation of interleukin-6 production; IEA:Ensembl.
DR GO; GO:1900226; P:negative regulation of NLRP3 inflammasome complex assembly; IEA:Ensembl.
DR GO; GO:1901223; P:negative regulation of non-canonical NF-kappaB signal transduction; IEA:Ensembl.
DR GO; GO:0032720; P:negative regulation of tumor necrosis factor production; IEA:Ensembl.
DR GO; GO:0042110; P:T cell activation; IEA:Ensembl.
DR CDD; cd00116; LRR_RI; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 4.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR041267; NLRP_HD2.
DR InterPro; IPR041075; NOD2_WH.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR24106; NACHT, LRR AND CARD DOMAINS-CONTAINING; 1.
DR PANTHER; PTHR24106:SF285; NLR FAMILY CARD DOMAIN-CONTAINING PROTEIN 3; 1.
DR Pfam; PF13516; LRR_6; 12.
DR Pfam; PF05729; NACHT; 1.
DR Pfam; PF17776; NLRC4_HD2; 1.
DR Pfam; PF17779; NOD2_WH; 1.
DR SMART; SM00368; LRR_RI; 14.
DR SUPFAM; SSF52047; RNI-like; 2.
DR PROSITE; PS50837; NACHT; 1.
PE 4: Predicted;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Reference proteome {ECO:0000313|Proteomes:UP000001595}.
FT DOMAIN 186..318
FT /note="NACHT"
FT /evidence="ECO:0000259|PROSITE:PS50837"
FT REGION 1..33
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 46..68
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 82..109
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1112 AA; 119937 MW; 8DB3792A9D3F51B7 CRC64;
TEMDAPRPPS LGVPGAASRP RRLLDGRHGR QQVQALSSQL LEVIPDSMKK QEVRTGREAG
QGHGTGSPAE QVKALMDLLA GKGSQGSQAP QAPDRTPDAP LGPCSNDSRI QRHRRALLSK
VGGVPELGRP WHRLASLLLV EGLTDLQLRE HDFTQVEATR GGGRPARTVA LDRLFLPLSR
VSVPPRVSIT IGVAGMGKTT LVRHFVRLWA HGQVGKDFSL VLPLTFRDLN THEKLCADRL
ICSVFPHVGE PSLAVAVPAR ALLILDGLDE CRTPLDFSNT VACTDPKKEI PVDHLITNII
RGNLFPEVSI WITSRPSASG QIPGGLVDRM TEIRGFNEEE IRVCLEQMFP EDQALLGWML
SQVQADRALY LMCTVPAFCR LTGAALGHLW RSRTGPQDAE LWPPRTLCEL YSWYFRMALS
GEGQETGKAS PRIEQVAHGG RKMVGTLGRL AFHGLLKKKY VFYEQDMKAF GVDLALLQGA
PCSCFLQREE TLASSVAYCF THLSLQEFVA AAYYYGASRR AIFDLFTESG VSWPRLGFLT
HFRSAAQRAM QAEDGRLDVF LRFLSGLLSP RVNALLAGSL LAQGEHQAYR TQVAELLQGC
LRPDATVCAR AINVLHCLHE LQHTELARSM EEAMESGALA RLTSPAHRAA LAYLLQVSDA
CAQEANLSLS LSQGVLQSLL PQLLYCRKLR LDTNQFQDPV MELLGSVLSG KDCRIQKISL
AENQISNKGA KALARSLLVN RSLTSLDLRG NSIGPQGAKA LADALKINRT LTSLSLQGNT
IRDDGARSMA EALASNRTLS MLHLQKNSIG PMGAQRMADA LKQNRSLKEL MLSSNSIGDG
GGKALAEALK VNQGLESLDL QSNSISDAGV AALMGALCTN QTLLSLSLRE NSISPEGAQA
IAHALRANST LKNLDLTANL LHDQGARAIA VAVRENRTLT SLHLQWNFIQ AGAAQALGQA
LQLNRSLTSL DLQENAIGDD GACAVARALK VNTALTALYL QVASIGAPGA QVLGEALAVN
RTLEILDLRG NAIGVAGAKA LANALKVNSS LRKLNLQENS LEMDGAICVA TALSGNHRLQ
HINLQGNHIG DSGARMISEA IKTNAPTCTV EM
//
