ID H2NR72_PONAB Unreviewed; 1110 AA.
AC H2NR72; A0A2J8VUR0;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 2.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=PLEKHG4 isoform 10 {ECO:0000313|EMBL:PNJ61252.1};
DE SubName: Full=Pleckstrin homology and RhoGEF domain containing G4 {ECO:0000313|Ensembl:ENSPPYP00000008418.2};
GN Name=PLEKHG4 {ECO:0000313|Ensembl:ENSPPYP00000008418.2};
GN ORFNames=CR201_G0015105 {ECO:0000313|EMBL:PNJ61252.1};
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000008418.2, ECO:0000313|Proteomes:UP000001595};
RN [1] {ECO:0000313|Ensembl:ENSPPYP00000008418.2, ECO:0000313|Proteomes:UP000001595}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Wilson R.K., Mardis E.;
RT "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:PNJ61252.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Susie {ECO:0000313|EMBL:PNJ61252.1};
RA Pollen A., Hastie A., Hormozdiari F., Dougherty M., Liu R., Chaisson M.,
RA Hoppe E., Hill C., Pang A., Hillier L., Baker C., Armstrong J.,
RA Shendure J., Paten B., Wilson R., Chao H., Schneider V., Ventura M.,
RA Kronenberg Z., Murali S., Gordon D., Cantsilieris S., Munson K., Nelson B.,
RA Raja A., Underwood J., Diekhans M., Fiddes I., Haussler D., Eichler E.;
RT "High-resolution comparative analysis of great ape genomes.";
RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSPPYP00000008418.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; NDHI03003408; PNJ61252.1; -; Genomic_DNA.
DR Ensembl; ENSPPYT00000008761.2; ENSPPYP00000008418.2; ENSPPYG00000007451.2.
DR eggNOG; KOG0689; Eukaryota.
DR GeneTree; ENSGT00940000158845; -.
DR HOGENOM; CLU_001356_3_0_1; -.
DR TreeFam; TF334329; -.
DR Proteomes; UP000001595; Chromosome 16.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd13242; PH_puratrophin-1; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR45845:SF4; PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING, FAMILY G (WITH RHOGEF DOMAIN) MEMBER 4; 1.
DR PANTHER; PTHR45845; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR-RELATED; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001595}.
FT DOMAIN 651..827
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 839..946
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1..104
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 625..649
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1065..1095
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..16
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 27..41
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1071..1095
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1110 AA; 123367 MW; B63F0A572E09555E CRC64;
MERPLENGDE SPDSQGHATD WRFAVCSFRD AWEEEEPASQ MHVKDPGPPR PPAGATQDEE
LQGSPLSRKL QLPPAADELG DAQRGTVERS SVVSEEPGPS GVESLLCPMS SHLSLAQGTR
DVQGRAVLLL CAHSPAWLQS ECSSQELIRL LLYLRSIPRA EVQALGLTVL VDARICSPSS
SLFSGLSQLQ EAVPGAVYQV LLVGSTLLKE VPSGLQLEQL PSQSLLTHIP TAGLPTSLGG
GLPYCHQAWL DFRRRLEALL QNCQAACALL QGAIESVKAM PQPMEPGEVG RLLQQTEVLM
QQVLDSPRLA WLQCQGGREL TWLKKEVPEV TLSPDYRTAM DKADELYDRV DGLLHQLTLQ
SNQRIQALEL VQTLEAREGG LHQIEVWLQQ VGWPALEEPG EPSLDMLLRA QGPFQELYQV
AQEQVRQGEK FLQPLTGWEA AELGPHGARF LALRAQLTEF SRALAQRCQR LTDAERLFQL
FREALTWAEE GQRLLAELEQ ERPGVVLQQL QLHWTRHPDL PPAHFRKMWA LATGLSSEAI
RQECRWAWAR CQDTWLALDQ KLEASLKLPP VGSTASLCVS QVPAAPAHPP LRKAYSFDRN
LGQSLSEPAR HCHHAATIAA CRRPEAGGGA LPQASPTVPP PGSSDPRSPN RLQLVLAEMV
ATEREYVRAL EYTMENYFPE LDRPDVPQGL RGQRAHLFGN LEKLRDFHCH FFLRELEACT
RHPPRVAYAF LRHRVQFGMY ALYSKNKPRS DALMSSYGHT FFKDKQQALG DHLDLASYLL
KPIQRMGKYA LLLQELARAC GGPTQELSAL REAQSLVHFQ LRHGNDLLAM DAIQGCDVNL
KEQGQLVRQD EFVVRTGRHK SVRRIFLFEE LLLFSKPRHG PTGVDTFAYK RSFKMADLGL
TECCGDSNLR FEIWFRRRKA RDTFVLQASS LAIKQAWTAD ISRLLWRQAV HNKEVRMAEM
VSMGVGNKAF RDIAPSEEAI NDRTINYVLK CREVRSRASI AVAPFDHDSL YLGALNSLPG
NPASCSVLGS LNLHLYRDPA LLGLRCPLYP NFSEESALEA EAELGGQPSL TAEDSEVSSQ
CPSASGSSGS DSSCVSRQAL GRGLEDLPCV
//
