ID H2NUZ3_PONAB Unreviewed; 5213 AA.
AC H2NUZ3;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 3.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=Ring finger protein 213 {ECO:0000313|Ensembl:ENSPPYP00000009784.3};
GN Name=RNF213 {ECO:0000313|Ensembl:ENSPPYP00000009784.3};
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000009784.3, ECO:0000313|Proteomes:UP000001595};
RN [1] {ECO:0000313|Ensembl:ENSPPYP00000009784.3, ECO:0000313|Proteomes:UP000001595}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Wilson R.K., Mardis E.;
RT "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPPYP00000009784.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR Ensembl; ENSPPYT00000010175.3; ENSPPYP00000009784.3; ENSPPYG00000008719.3.
DR eggNOG; ENOG502QQ65; Eukaryota.
DR GeneTree; ENSGT00630000089884; -.
DR HOGENOM; CLU_000066_0_0_1; -.
DR InParanoid; H2NUZ3; -.
DR TreeFam; TF329577; -.
DR Proteomes; UP000001595; Chromosome 17.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR CDD; cd16561; RING-HC_RNF213; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR031248; RNF213.
DR InterPro; IPR046439; ZF_RZ_dom.
DR InterPro; IPR018957; Znf_C3HC4_RING-type.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR22605:SF16; E3 UBIQUITIN-PROTEIN LIGASE RNF213; 1.
DR PANTHER; PTHR22605; UNCHARACTERIZED; 1.
DR Pfam; PF00097; zf-C3HC4; 1.
DR Pfam; PF20173; ZnF_RZ-type; 1.
DR SMART; SM00382; AAA; 2.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
DR PROSITE; PS51981; ZF_RZ; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000001595};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 4008..4046
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 4491..4563
FT /note="RZ-type"
FT /evidence="ECO:0000259|PROSITE:PS51981"
FT REGION 27..371
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 118..162
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 211..228
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 251..269
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 296..310
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 311..365
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 5213 AA; 591896 MW; 630D0AFC4EE39CF6 CRC64;
MECPSCQHVS KEEAPRFCSQ CGERLPPAAP IADSENNNST MASAPEGEME CGQELKEEEG
LCLFPGSDSW QENPDKPCSD ASWTVQESKK KKRKKKKIWN NSPSSEVASL PLSPASPCHL
TLLSNPGPQD TALPHSQAQQ SGPTGQPSQP PGTATTPLEG DGLSTPTEVG DSPLQARALG
EAGVATGSEA LSSPQSQHHT EGEDQDASIP SGGRGLSQEG TIPPTSAGEG RSRTEDAAQE
LLLPESKGGS SEPRTEPQTT EQQAGTPAST AVDAAAEPAN TVKGAGKEMK EKTQRTKQPP
ATTPASKTHC QEAETKTKTK DETAAAGEKV GKNERGEPED LKKPEGKNRS AAAVKKDKEQ
KNQKAGVQEV KASTLSPGGG VTVYFHAIIS HHFSFSPDHH KVFIRGGEEF GEPKWASNVC
ELYYSRDLGH DGVLVEGSVV ISKKHLDKYI PYKYIIYNKG SAEYEFIYKR QQKEGEHVNR
CLLIKSSLLG SGDWHQYDDI VCMKPPGKLQ KVMNHITDGS RKDLVKGKHT AATVMLDSIF
SILQTWDTIN LNSFFTQFQQ FYFVMQQPMI YEGQAQPWTD LQYGEKEVKR YLWEYLKKHM
VPLLDRKSAD SLPIDGPVRS KLKMGLIVLF IVEKIQFLLE DSLTLLCHLL TSDASSPDEF
HSDLSHILGI PQSWRLYLVN LCQRCMDTSM YNWLGALPVL HCCMELAPRH KDAWSQPEDT
WAALEGISFS QFREQMLDTS SLLQFMNQKK HLLSIDEPLF RSWFSLLPLS HLVQYMEDFM
EHLCHFPAHI LDCFLGIYYR LPGLQKVWNM QVCDVQNVQN ILKMLLHLLD TYQDKIPEEA
LSPSYLIVCL KLHEAICSST KIPKFYELPA LSAEIVCRMI ILLSLVDSAG QGDETGNNSV
QTVFQGTLAA TKRWLQEVFT ENMLAYSGAS FTYVEEIEVW RRLVEIHFPM EHGWKESLLG
DMEWRLKQEK PLSQITAYCN SRWDTKGLED SVAKTFEKCA IEAVSSACQS QTSILQGLSC
SDLRKFGTLL SAVITKSWPR NNGEAVDDFD DILKHLLTLA DVKHLFRLCG TDEKIRANIT
QDGKKLMAAA DSVFTKVVGD LLTGTILVGQ LELIIKHKNQ FLDIWQLKEK SLSPQDEKYA
VEEALDWRME ELLFLKKEKR CVDSLLKMCG NVKHLIQVDF GVLAVRYSQD LSSKRLNEAV
TVRLSTSSNS QRTTHYDLSS RVREMAGKID LLRDSHIFQI FWREAAEPLG EPKEDREAAE
LLSEPEEESE RHILELEEVY DYLYQPSYRK FIKLYQDLKS GEVTLAEIDV IFKDFVNKYM
DLDSELKIMC TVDHQGQRDW IKERVEQIKE YHHLHQAVHA AKVILQVKES LGLTGDFSVL
NTLLNFTDNF DDFRHETLDQ INQELIRAKK LLQDISEARC KGLKALSLRK DFICWVREAL
GGINELKVFV DLASISAGEN DIDVDRVACF HDAVQGYASL LFKLDPRVGF SAFMKHLKEL
WKALDNDQYL PRKLCDSARN LEWLKTVKES HGSVELSSLT LATAINQRGI YVIQAPKGGQ
KISPDTVLHL ILPESPGSHE ERREYSLEEL KELLNKLMLM SGKKDHNNTE VERFSEVFCS
VQRLSQAFID LHSAGNMLFR TWIATAYCSP KQGVSLQMDF GLDLVTKLAE GGDVIELLAA
LCRQMEHFLD SWKRFVTQKR MEHFYLNFYT AEQLVYLSTE LRKQPPSDAA LTMLSFIKSN
CTLRDVLRAS VGCESEAARY RMRTVMEELP LMLFSEFSLV DKLRVIMEQS MGCLPAFLPD
CLDLETLGRC LAHLAGMGGS PVERCLPRGL QVGQPNLVVC GHSEVLPAAL AVYMQTPSQP
LPTYDEVLLC TPATTFEEVA LLLRRCLTLG SPGHKVYSLL FADQLSYEVA RQAEKLFQKL
CTQQHREDYQ LVMVCDGDWE HCYLPSAFSQ HKVFVTPQAP LEAIQAYLAG HYRVPKQTLS
AAAVFKDRLC VGIVASERAG VGKSLYVKRL HDKLKMQLNV KKVPLKTIRL IDPQVDESQV
LGALLPFLDV QYQKVPVLFH LDVTSSVQSG IWVFLFKLLI LQYLMDINGK MWLRNPCHLY
IVEILERRTS VPSRRSSTLR TRVPQFSFLD IFPKVTCRPP KEVIDMELSP RRSDTEPGMD
QWEFCSETFQ RPYQYLRRFH QNQNLDTFQY QEGSVEGTPE ECLQHFLIYC GVINPSWSEL
RNFARFLNYQ LRDCEASLFC NPSFIGDTLR GFKNFVVTFM IFMARDFATP SLHTSDESPG
KHMVTMDGVR EEDLAPFSLR KRWESEPHPY VFFNDDHTTM TFIGFHLQPN SKGSVDAINH
LTRKVIKRDV MTTDLYQGLL LQRVPFNVDF DKLPRHEKLE RLCLTLGIPW ATDPDKTYEL
TTDNMLKILA IEMRFRCGIP VIIMGETGCG KTRLIKFLSD LRRGGANSDT IKLVKVHGGT
TADMIYSRVR EAEDVAFANK DQHQLDTILF FDEANTTEAI SCIKEVLCDR MVDGQPLAED
SGLHIIAACN PYRKHSEEMI CRLESAGLGY RVSMEETADR LGSIPLRQLV YRVHALPPSL
IPLVWDFGQL SDVAEKLYIQ QIVQRLVDSI SLDENGTRVI TEVLCASQGF MRKREDECSF
VSLRDVERCV KVFRWFHEHS AMLLAQLNAF LSKSRVSKDH TKRDPVLWSL MLAIGVCYHA
SLEKKDSYRK AIARFFPKPY DDSRLLLDEI TRAQDLFLDG VPLRKTIAKN LALKENVFMM
VICIELKIPL FLVGKPGSSK SLAKTIVADA MQGPAAYSDL FRSLKQVHLV SFQCSPHSTP
QGIISTFRQC ARFQQGKDLQ QYVSVVVLDE VGLAEDSPKM PLKTLHPLLE DGCIEDDPAP
HKKVGFVGIS NWALDPAKMN RGIFVSRGSP NKRELIESAK GICSSDILVQ DRVQGYFSSF
AKAYETVCES QDKEFFGLRD YYSLIKMVFA AAKASNRKPS PQDIAQAVLR NFSGKDDIRA
LDIFLANLPE AKSSEEVSPV QLIKQNIFGP SQKVPDGQLE DAESRYLLVL TKNYVALQIL
QQTFFEEDQQ PEIIFGSGFP KDQEYTQICR NINRVKICME TGKMVLLLNL QNLYESLYDA
LNQYYVHLGG QKYVDLGLGT HRVKCRVHPN FRLIVIEEKD VVYKHFPIPL INRLEKHYLD
INTVLEKWQK SIVEELRAWV EKFINVKADH FLNRHKYSPS DVFIGYHSDA CASVVLQVIE
RRGPRALTEE LYQKVSGEAK LILLNCATPD AMVRLSAYSL GGFAGKSLSR EYFYRQRHNS
FADFLQAHLH ATDLERHAIF TEITTFSRLL TSHDCEILEL EVTGRAPKPT LLWLQQFDTE
YSFLKEVRNC LTNTAKCKIL IIQTDFEDGI HSAQLIASAK YSAINEINKI QENEDRIFVY
FITKLSRMGR GTAYVGFHGG LWQSVHIDDL RRSTLMVSDV TRLQHVTISQ LFAPGDLPEL
GLEHRAEDGH EEAMETEAST SGEVAEVAEE AEVAEEAMET ESSEKVGKET SELGGSDVSI
LDTTRLLRSC VQSAVGMLRD ENESCTRNMR RVVLLLGLLN EDDTCHASFL RVSKMRLNVL
LKKQEESQVH PLEWVAREAC NQDALQEAGT FRHTLWKRVQ GAVTPLLASI ISFIDRDGNL
ELLTRPDTPP WARDLWMFIY SDTTLLNIPL VMNNERHKGE MAYIMVQNYM NLSENASNNV
PFSWRIKDYL EELWVQAQYI TDAEGLPKKF VDIFQQTPLG RFLAQLHGET QQELLQCYSK
DFILLTMRVS TEEELKFLQM ALWSCTRELK AASAAPEEEV SLPWVHLAYQ RFRSRLQNFS
RILTIYPQVL HSLMEARRNH ELAGCEMTLD AFAAMACTEM LTRDTLKPSP QAWLQLVKNL
SMPLELICSD GHTQGSGSLA QAVIREVRAQ WSRIFSTALF VEHVLLGTES QVPELHRLVT
EHVFLLDKCL RENSDVKTHR PFEAVMSTLC ECKERASKTL SRFGVQPCPI CLGDAEDPVC
LPCDHVHCLR CLRAWFAPGQ MMCPYCLTAL PDEFSPAVSQ AHREAIEKHA RFRQMCNSFF
VDLVSTMCFK DNAPPEKKVI ESLLSLLFVQ KELLRDAPQR HREHTKSLSP FNDVVDKTPV
IRSVILKLLL KYSFNDVKDY IQEYLTLLKK KAFIIEDKTE LYMLFINCLE DSIHEKTSAC
SRNDELNHLR EERRFLKMYS QGRRGREPAN EASVEYLQEV ARIRLCLDRA ADFLSEPEEG
PEMAEEKQCY LRQVKHFCIW VENDWHRVYL VRKLSSQRGM EFVQGLSKPG HPHQWVFPKD
VVKQQQDHPG QMDRYLVYGD EYKALRDAVA KAVLECKPLG IETALKACKT PQNRQSACFL
LTLFREVAVL YRSHSASLHP TPEQREAVSK FIGECKILSP PDISHFATSL VDNSLPLLRA
GPSDSNLDGT VTEMAIHAAA VLLCGQNKLL EPLKNLAFSP ANMAHAFLPT MPEDLLAQAR
RWKGLEGVHW YTCPNGHPCS VGECGKPMEQ STCIDCHAPI GGINHKPRDG FRLVNDRADR
TQTGHVLGDP QQRDVVTCDR GLPPVVFILI RLLTHLALLL GASQSSQALI NIIKPLARDP
KGFLQQHILK DLEQLAKMLG HSADETITVV HLVLRRLLQG QHQLSSKRLL NFDTRLSTKE
MRNNWEKEIA AVISPELEHL DKTLPTMNNL ISQDKRISSN PVAKIIYGDP VTFLPHLPQK
SVVHCSKIWS CRKRITVEYL QHIVEQKNGK ERVPILWRFL QKEAELRLVK FLPEILALQR
GLVKQFQNVP QVEYNSIRGF LSKHSSGGLR RLLQNRITVF LSTWNKLRRS LEMNGEINLP
KAYCSTDLDL DADFEILLPR RRGLGLCATA LVSYLIRLHN EIVYAVEKLP EGNNSYSVDA
TEVTDLHVIS YEVERDLTPL ILSNCQYQVE QGRETLQEFD LEKIQQQIVS RFIQGKPRLS
LKGIPTLVYR HDRNYEHLFM DIKNKMAQDS LPSSVISAIS GQLQSYSDAC EALSVVEVTL
GFLSTAGGDP NMHLNVYTQD ILQMGDQTTH VLKALNRCQL KHTIALWQFL SAHKSEQLLR
LQKEPFGEIS SRYKVDLSSE NAKLLSTFLN QIGLDAFLLE LHEMIILKLK NPQTEGSFNH
EWSLRDTLIS YMETKESEIL PEMESQFPEE ILLANCVSVW KTAAVLKRNR QIR
//
