ID   H2NVI8_PONAB            Unreviewed;       891 AA.
AC   H2NVI8; A0A2J8W948;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   25-MAY-2022, sequence version 2.
DT   27-MAR-2024, entry version 62.
DE   SubName: Full=TTLL6 isoform 1 {ECO:0000313|EMBL:PNJ66304.1};
DE   SubName: Full=Tubulin tyrosine ligase like 6 {ECO:0000313|Ensembl:ENSPPYP00000009989.2};
GN   Name=TTLL6 {ECO:0000313|Ensembl:ENSPPYP00000009989.2};
GN   ORFNames=CR201_G0012330 {ECO:0000313|EMBL:PNJ66304.1};
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000009989.2, ECO:0000313|Proteomes:UP000001595};
RN   [1] {ECO:0000313|Ensembl:ENSPPYP00000009989.2, ECO:0000313|Proteomes:UP000001595}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Wilson R.K., Mardis E.;
RT   "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
RL   Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:PNJ66304.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Susie {ECO:0000313|EMBL:PNJ66304.1};
RA   Pollen A., Hastie A., Hormozdiari F., Dougherty M., Liu R., Chaisson M.,
RA   Hoppe E., Hill C., Pang A., Hillier L., Baker C., Armstrong J.,
RA   Shendure J., Paten B., Wilson R., Chao H., Schneider V., Ventura M.,
RA   Kronenberg Z., Murali S., Gordon D., Cantsilieris S., Munson K., Nelson B.,
RA   Raja A., Underwood J., Diekhans M., Fiddes I., Haussler D., Eichler E.;
RT   "High-resolution comparative analysis of great ape genomes.";
RL   Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSPPYP00000009989.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|ARBA:ARBA00001946};
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DR   EMBL; NDHI03003397; PNJ66304.1; -; Genomic_DNA.
DR   STRING; 9601.ENSPPYP00000009989; -.
DR   Ensembl; ENSPPYT00000010389.2; ENSPPYP00000009989.2; ENSPPYG00000008906.3.
DR   eggNOG; KOG2158; Eukaryota.
DR   GeneTree; ENSGT00940000161434; -.
DR   HOGENOM; CLU_010131_7_2_1; -.
DR   OMA; LFPAHYN; -.
DR   TreeFam; TF313087; -.
DR   Proteomes; UP000001595; Chromosome 17.
DR   GO; GO:0097731; C:9+0 non-motile cilium; IEA:Ensembl.
DR   GO; GO:0036064; C:ciliary basal body; IEA:Ensembl.
DR   GO; GO:0015631; F:tubulin binding; IEA:Ensembl.
DR   GO; GO:0070740; F:tubulin-glutamic acid ligase activity; IEA:Ensembl.
DR   GO; GO:0001578; P:microtubule bundle formation; IEA:Ensembl.
DR   GO; GO:0051013; P:microtubule severing; IEA:Ensembl.
DR   GO; GO:0003353; P:positive regulation of cilium movement; IEA:Ensembl.
DR   GO; GO:0036211; P:protein modification process; IEA:InterPro.
DR   GO; GO:0060296; P:regulation of cilium beat frequency involved in ciliary motility; IEA:Ensembl.
DR   Gene3D; 3.30.470.20; ATP-grasp fold, B domain; 1.
DR   InterPro; IPR004344; TTL/TTLL_fam.
DR   PANTHER; PTHR12241; TUBULIN POLYGLUTAMYLASE; 1.
DR   PANTHER; PTHR12241:SF96; TUBULIN POLYGLUTAMYLASE TTLL6; 1.
DR   Pfam; PF03133; TTL; 1.
DR   SUPFAM; SSF56059; Glutathione synthetase ATP-binding domain-like; 1.
DR   PROSITE; PS51221; TTL; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000001595}.
FT   REGION          48..106
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          556..584
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          608..629
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          800..820
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        60..79
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        800..814
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   891 AA;  101372 MW;  63999842BBC1DE5A CRC64;
     MGALLLHPSR RGPAGVVASW TSSPAGRDGG VGIAGACYFP RASSQAREMP QCPTLESQEG
     ANSEEKRDSS KEDPKETVAL AFVRENPGAQ NGLQNAQQQG KKKRKKKRLV INLSSCRYES
     VRRAAQQYGL REGGEDDDWT LYWTDYSVSL ERVMEMKSYQ KINHFPGMSE ICRKDLLARN
     MSRMLKMFPK DFHFFPRTWC LPADWGDLQT YSRSRKNKTY ICKPDSGCQG KGIFITRTVK
     EIKPGEDMIC QLYISKPFII DGFKFDLRIY VLVTSCDPLR IFVYNEGLAR FATTSYSRPC
     TDNLDDICMH LTNYSINKHS SNFSRDAHSG SKRKLSTFNA YMEDHSYNVE QIWRDIEDVI
     IKTLISAHPI IRHNYHTCFP NHTLNSACFE ILGFDILLDR KLKPWLLEVN HSPSFSTDSR
     LDKEVKDGLL YDTLVLINLE SCDKKKVLEE ERQRGQFLQQ CCSREMRTEE AKGFRAVQSK
     KTETYEKENC GGFRLIYPSL NSEKYEKFFQ DNNSLFQNTV ASRAREEYAR QLIQELRLKR
     EKKPFQMKKK VEMWGESAGK QVRKKGMRGW QQKQQQKDKA ATQASKQYIQ PLTLVSYTPD
     LLLSVRDERK NETDSSLNQE ASTKEAGPIF PKLTSVRPFS SVPDLRNINL SSSKLEPSKP
     TFSIKEARSA SAVNVFTGTV HLTSVETTPE STTQLSISPK SPPILAVTAS SEYSGPETDR
     VVSFKCKKQQ TPPHLTQKKM VKPFLPTKSK SFWGSPNTNW TLLKSDMNKP HLISELLTKL
     QLSGKLSFFP AHYNPKLGMN NLSQNPSLPG ECHSRSDSSG EKRQLDVSSL LLQSPQSYNV
     TLRDLLVIAT PARLDPRPCR SHTSAMRDPC MQDQEAYSHC LISGQKGCER S
//