ID H2NZ13_PONAB Unreviewed; 525 AA.
AC H2NZ13; A0A2J8R2A7;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 2.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=CEA cell adhesion molecule 1 {ECO:0000313|Ensembl:ENSPPYP00000011247.2};
DE SubName: Full=CEACAM1 isoform 2 {ECO:0000313|EMBL:PNJ02663.1};
GN Name=CEACAM1 {ECO:0000313|Ensembl:ENSPPYP00000011247.2};
GN ORFNames=CR201_G0054637 {ECO:0000313|EMBL:PNJ02663.1};
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000011247.2, ECO:0000313|Proteomes:UP000001595};
RN [1] {ECO:0000313|Ensembl:ENSPPYP00000011247.2, ECO:0000313|Proteomes:UP000001595}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Wilson R.K., Mardis E.;
RT "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:PNJ02663.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Susie {ECO:0000313|EMBL:PNJ02663.1};
RA Pollen A., Hastie A., Hormozdiari F., Dougherty M., Liu R., Chaisson M.,
RA Hoppe E., Hill C., Pang A., Hillier L., Baker C., Armstrong J.,
RA Shendure J., Paten B., Wilson R., Chao H., Schneider V., Ventura M.,
RA Kronenberg Z., Murali S., Gordon D., Cantsilieris S., Munson K., Nelson B.,
RA Raja A., Underwood J., Diekhans M., Fiddes I., Haussler D., Eichler E.;
RT "High-resolution comparative analysis of great ape genomes.";
RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSPPYP00000011247.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the immunoglobulin superfamily. CEA family.
CC {ECO:0000256|ARBA:ARBA00038222}.
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DR EMBL; NDHI03003798; PNJ02663.1; -; Genomic_DNA.
DR STRING; 9601.ENSPPYP00000011247; -.
DR Ensembl; ENSPPYT00000011686.2; ENSPPYP00000011247.2; ENSPPYG00000010050.3.
DR eggNOG; ENOG502RXPD; Eukaryota.
DR GeneTree; ENSGT01100000263479; -.
DR HOGENOM; CLU_024555_2_1_1; -.
DR OMA; QCEVSNA; -.
DR TreeFam; TF336859; -.
DR Proteomes; UP000001595; Chromosome 19.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd20948; IgC2_CEACAM5-like; 1.
DR CDD; cd05740; IgI_hCEACAM_2_4_6_like; 1.
DR CDD; cd05774; IgV_CEACAM_D1; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 4.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013106; Ig_V-set.
DR InterPro; IPR013151; Immunoglobulin.
DR PANTHER; PTHR44427:SF1; CARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE 1; 1.
DR PANTHER; PTHR44427; CARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE 19; 1.
DR Pfam; PF00047; ig; 1.
DR Pfam; PF13895; Ig_2; 1.
DR Pfam; PF13927; Ig_3; 1.
DR Pfam; PF07686; V-set; 1.
DR SMART; SM00409; IG; 4.
DR SMART; SM00408; IGc2; 3.
DR SUPFAM; SSF48726; Immunoglobulin; 4.
DR PROSITE; PS50835; IG_LIKE; 3.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001595};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..34
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 35..525
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041157922"
FT TRANSMEM 428..453
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 145..232
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 237..317
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 323..412
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 460..525
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 460..475
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 476..516
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 525 AA; 57758 MW; E1EDACC47DBEBFAE CRC64;
MGHLSAPLHR VRVPWQGLLL TASLLTFWNP PTTAQLTTES TPFNVAEGKE VLLLVHNLPQ
NPLGYNWYKG EMVDANHRII GYVISDQLTT PGPAYSSREK IYPNASLLIQ NVTQNDTGFY
TLQVIKSDLV NEEATGQFHV YPETPKPFIS SNNSNPVEDN DAVALTCEPG TQDTTYLWWI
NNQSLLISPR LQLSNGNRTL TLLSVTRNDA GPYECEIQNP VSANRSDPVT LNVTYGPDTP
TISPSDTYYR PGANLSLSCY AASNPPAQYS WLINGTFQQS TQELFIPNIT VNNSGSYTCH
ANNSVTGRNR TTVKTIIVTE LSPVVKPQIK ASKTTVTEDK DSVNLTCSTN DTGISISWFF
ENQSLPSSER MKLSQGNTTL SINPVKREDA GKYWCEVFNS ISKNQSDPIM LTVKYNYPSQ
ENGLSAGAIA GIVIGVLALV ALIAVALACF LHFRKTGRAS DQRDLTEHKP SVSNHTQDHS
NDPPNKMNEV TYSTLNFEAQ QPTQSTSASP SPTATEIIYS EVKKK
//
