ID H2P029_PONAB Unreviewed; 499 AA.
AC H2P029; A0A2J8XR32; A0A6D2WI86;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=LILRA4 isoform 1 {ECO:0000313|EMBL:PNJ84482.1};
DE SubName: Full=Leukocyte immunoglobulin like receptor A4 {ECO:0000313|Ensembl:ENSPPYP00000011626.1};
GN Name=LILRA4 {ECO:0000313|Ensembl:ENSPPYP00000011626.1};
GN ORFNames=CR201_G0053805 {ECO:0000313|EMBL:PNJ84482.1};
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000011626.1, ECO:0000313|Proteomes:UP000001595};
RN [1] {ECO:0000313|Ensembl:ENSPPYP00000011626.1, ECO:0000313|Proteomes:UP000001595}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Wilson R.K., Mardis E.;
RT "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:PNJ84482.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Susie {ECO:0000313|EMBL:PNJ84482.1};
RA Pollen A., Hastie A., Hormozdiari F., Dougherty M., Liu R., Chaisson M.,
RA Hoppe E., Hill C., Pang A., Hillier L., Baker C., Armstrong J.,
RA Shendure J., Paten B., Wilson R., Chao H., Schneider V., Ventura M.,
RA Kronenberg Z., Murali S., Gordon D., Cantsilieris S., Munson K., Nelson B.,
RA Raja A., Underwood J., Diekhans M., Fiddes I., Haussler D., Eichler E.;
RT "High-resolution comparative analysis of great ape genomes.";
RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSPPYP00000011626.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; NDHI03003344; PNJ84482.1; -; Genomic_DNA.
DR RefSeq; XP_002829783.1; XM_002829737.2.
DR STRING; 9601.ENSPPYP00000011626; -.
DR Ensembl; ENSPPYT00000012070.2; ENSPPYP00000011626.1; ENSPPYG00000010379.2.
DR GeneID; 100459365; -.
DR KEGG; pon:100459365; -.
DR CTD; 23547; -.
DR eggNOG; ENOG502RYEX; Eukaryota.
DR GeneTree; ENSGT01100000263478; -.
DR HOGENOM; CLU_021100_2_0_1; -.
DR OMA; FENNTPY; -.
DR OrthoDB; 5353978at2759; -.
DR TreeFam; TF336644; -.
DR Proteomes; UP000001595; Chromosome 19.
DR GO; GO:0032998; C:Fc-epsilon receptor I complex; IEA:Ensembl.
DR GO; GO:0015026; F:coreceptor activity; IEA:Ensembl.
DR GO; GO:0005102; F:signaling receptor binding; IEA:Ensembl.
DR GO; GO:0038095; P:Fc-epsilon receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0032687; P:negative regulation of interferon-alpha production; IEA:Ensembl.
DR GO; GO:0034156; P:negative regulation of toll-like receptor 7 signaling pathway; IEA:Ensembl.
DR GO; GO:0034164; P:negative regulation of toll-like receptor 9 signaling pathway; IEA:Ensembl.
DR GO; GO:0032720; P:negative regulation of tumor necrosis factor production; IEA:Ensembl.
DR CDD; cd05751; IgC2_D1_LILR_KIR_like; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 4.
DR InterPro; IPR016332; A1B_glyco/leuk_Ig-like_rcpt.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013151; Immunoglobulin.
DR PANTHER; PTHR11738:SF98; LEUKOCYTE IMMUNOGLOBULIN-LIKE RECEPTOR SUBFAMILY A MEMBER 4; 1.
DR PANTHER; PTHR11738; MHC CLASS I NK CELL RECEPTOR; 1.
DR Pfam; PF00047; ig; 2.
DR Pfam; PF13895; Ig_2; 2.
DR PIRSF; PIRSF001979; Alpha_1B_glycoprot_prd; 1.
DR SMART; SM00409; IG; 4.
DR SMART; SM00408; IGc2; 3.
DR SUPFAM; SSF48726; Immunoglobulin; 4.
DR PROSITE; PS50835; IG_LIKE; 3.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR001979-1};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Reference proteome {ECO:0000313|Proteomes:UP000001595};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..499
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014574907"
FT DOMAIN 123..195
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 224..313
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 324..407
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DISULFID 49..98
FT /evidence="ECO:0000256|PIRSR:PIRSR001979-1"
FT DISULFID 143..195
FT /evidence="ECO:0000256|PIRSR:PIRSR001979-1"
SQ SEQUENCE 499 AA; 55154 MW; E14526A9189EB15C CRC64;
MTPILTTLLF FGLSLGPRTR VQAENLLKPF LWAEPGPVIT WSKPVTIWCQ GTLEAQEYRL
DKEGNSMSRH ILKTLESENK VKFSIPSMMW EHAGRYHCYY QSPAGWSEPS DPLELVVTAY
SRPTLSALPS PVVTSGVNVT LRCASRLGLG RFTLIEEGDH RLSWTLDSHQ HNHGKFQALF
PMGPLTFSNR GTFRCYGYEN NTPYVWSEPS DPLQLLVSGV SRKPSLLTLQ GPVVTPGENL
TLQCGSDVGY IRYALYKEGG DDLPQRPGQQ PQAGLSQASF TLSPVRGSHG GQYRCYGAHN
ISSEWSAPSD PLDILIAGQI SDRPSLSVQL GPTVTSGEKV TLLCQSWGPM FTFLLTKEGA
ADAPLRLRST YRAQQYQAEF PMSPVTSAHA GTYRCYGSRS SNPYLLSHPS EPLELVVSGA
TETLNPAQKK SDSKTASHPQ DYTVENLIRM GLAGLVLVFL GILLFEAHHS QRSPPRCSQE
ANSREDNAPF RVVEPWEQI
//
