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Database: UniProt
Entry: H2P7Q1_PONAB
LinkDB: H2P7Q1_PONAB
Original site: H2P7Q1_PONAB 
ID   H2P7Q1_PONAB            Unreviewed;      1955 AA.
AC   H2P7Q1;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   28-MAR-2018, entry version 45.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=SCN9A {ECO:0000313|Ensembl:ENSPPYP00000014397};
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Pongo.
OX   NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000014397, ECO:0000313|Proteomes:UP000001595};
RN   [1] {ECO:0000313|Ensembl:ENSPPYP00000014397, ECO:0000313|Proteomes:UP000001595}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Wilson R.K., Mardis E.;
RT   "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
RL   Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSPPYP00000014397}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
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DR   EMBL; ABGA01187017; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABGA01187018; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABGA01187019; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABGA01187020; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABGA01187021; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABGA01187022; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABGA01187023; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABGA01187024; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABGA01187025; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABGA01187026; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9601.ENSPPYP00000014397; -.
DR   Ensembl; ENSPPYT00000014983; ENSPPYP00000014397; ENSPPYG00000012899.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   InParanoid; H2P7Q1; -.
DR   OMA; RQKCPPW; -.
DR   OrthoDB; EOG091G00FK; -.
DR   TreeFam; TF323985; -.
DR   Proteomes; UP000001595; Chromosome 2b.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005244; F:voltage-gated ion channel activity; IEA:UniProtKB-KW.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:Ensembl.
DR   GO; GO:0048266; P:behavioral response to pain; IEA:Ensembl.
DR   GO; GO:0006954; P:inflammatory response; IEA:Ensembl.
DR   GO; GO:0009791; P:post-embryonic development; IEA:Ensembl.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   GO; GO:0009636; P:response to toxic substance; IEA:Ensembl.
DR   GO; GO:0019233; P:sensory perception of pain; IEA:Ensembl.
DR   Gene3D; 1.20.120.350; -; 4.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR024583; Na_trans_cytopl.
DR   InterPro; IPR028803; SCN9A.
DR   InterPro; IPR027359; Volt_channel_dom_sf.
DR   PANTHER; PTHR10037:SF221; PTHR10037:SF221; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   Pfam; PF11933; Na_trans_cytopl; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   SMART; SM00015; IQ; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001595};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000256|SAAS:SAAS00085096};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001595};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000256|SAAS:SAAS00084820};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000256|SAAS:SAAS00084701};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    122    146       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    191    210       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    222    243       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    249    269       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    340    359       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    379    406       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    738    764       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    776    794       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    814    835       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    856    884       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    946    969       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1194   1212       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1233   1249       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1325   1345       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1394   1415       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1435   1458       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1517   1535       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1547   1565       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1577   1597       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1634   1662       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1738   1761       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN      127    412       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      485    695       Na_trans_cytopl. {ECO:0000259|Pfam:
FT                                PF11933}.
FT   DOMAIN      746    974       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      983   1188       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN     1192   1467       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1516   1771       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED      277    297       {ECO:0000256|SAM:Coils}.
FT   COILED      403    441       {ECO:0000256|SAM:Coils}.
FT   COILED      687    707       {ECO:0000256|SAM:Coils}.
FT   COILED     1021   1041       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1955 AA;  222595 MW;  4D394D9E8162282D CRC64;
     MAMLPPPGPQ SFVHFTKQSL ALIEQRIAER KSKEPKEEKK DDDEEAPKPS SDLEAGKQLP
     FIYGDIPPGM VSEPLEDLDP YYADKKTFIV LNKGKTIFRF NATPALYMLS PFSPLRRISI
     KILVHSTLFS MLIMCTILTN CIFMTMNNPP DWTKNVEYTF TGIYTFESLV KILARGFCVG
     EFTFLRDPWN WLDFVVIVFA YLTEFVNLGN VSALRTFRVL RALKTISVIP GLKTIVGALI
     QSVKKLSDVM ILTVFCLSVF ALIGLQLFMG NLKHKCFRNS LENNETLESI MNTLESEEDF
     RKYFYYLEGS KDALLCGFST DSGQCPEGYT CMKIGRNPDY GYTSFDTFSW AFLALFRLMT
     QDYWENLYQQ TLRAAGKTYM IFFVIVIFLG SFYLINLILA VVAMAYEEQN QANIEEAKQK
     ELEFQQMLDR LKKEQEEAEA IAVAAAEYTS IRRSRIMGLS ESSSETSKLS SKSAKERRNR
     RKKKNQKKPS SGEEKGDAEK LSKSESEDSI RRKSFHLGVE GHRRAHEKRL STPNQSPLSI
     RGSLFSARRS SRTSLFSFKG RGRDIGSETE FADDEHSIFG ENESRRGSLF VPHRPQERRS
     SNISQASRSP PMLPVNGKMH SAVDCNGVVS LVDGRSALML PNGQLLPEVI IDKATSDDSG
     TTNQIHKKRH CSSYLLSEDM LNDPNLRQRA MSRASILTNT VEELEESRQK CPPWWYRFAH
     KFLIWNCSPY WIKFKKCIYF IVMDPFVDLA ITICIVLNTL FMAMEHHPMT EEFKNVLAIG
     NLVFTGIFAA EMVLKLIAMD PYEYFQVGWN IFDSLIVTLS LVELFLADVE GLSVLRSFRL
     LRVFKLAKSW PTLNMLIKII GNSVGALGNL TLVLAIIVFI FAVVGMQLFG KSYKECVCKI
     SDDCRLPRWH MNDFFHSFLI VFRVLCGEWI ETMWDCMEVA GQAMCLIVYM MVMVIGNLVV
     LNLFLALLLS SFSSDNLTAI EEDPDANNLQ IAVTRIKKGI NYVKQTLHEF ILKAFSKKPK
     ISREIRQAED LNTKKENYIS NHTLAEMSKG HNFLKEKDKI SGFGSSVDKH LMEDSDGQSF
     IHNPSLTVTV PIAPGESDLE NMNTEELSSD SDSEYSKVRL NRSSSSECST VDNPLPGEGE
     EAEAEPMNSD EPEACFTDGC VRRFSCCQVN IESGKGKIWW NIRKTCYKIV EHSWFESFIV
     LMILLSSGAL AFEDIYIERK KTIKIILEYA DKIFTYIFIL EMLLKWIAYG YKTYFTNAWC
     WLDFLIVDVS LVTLVANTLG YSDLGPIKSL RTLRALRPLR ALSRFEGMRV VVNALIGAIP
     SIMNVLLVCL IFWLIFSIMG VNLFAGKFYE CINTTDGSRF PASQVPNRSE CFALMNVSQN
     VRWKNLKVNF DNVGLGYLSL LQVATFKGWT IIMYAAVDSV NVDKQPKYEY SLYMYIYFVI
     FIIFGSFFTL NLFIGVIIDN FNQQKKKLGG QDIFMTEEQK KYYNAMKKLG SKKPQKPIPR
     PGNKIQGCIF DLVTNQAFDI SIMVLICLNM VTMMVEKEGQ SQHMTEVLYW INVVFIILFT
     GECVLKLISL RHYYFTVGWN IFDFVVVIIS IVGMFLADLI ETYFVSPTLF RVIRLARIGR
     ILRLVKGAKG IRTLLFALMM SLPALFNIGL LLFLVMFIYA IFGMSNFAYV KKEDGINDMF
     NFETFGNSMI CLFQITTSAG WDGLLAPILN SKPPDCDPKK VHPGSSVEGD CGNPSVGIFY
     FVSYIIISFL VVVNMYIAVI LENFSVATEE STEPLSEDDF EMFYEVWEKF DPDATQFIEY
     SKLSDFAAAL DPPLLIAKPN KVQLIAMDLP MVSGDRIHCL DILFAFTKRV LGESGEMDSL
     RSQMEERFMS ANPSKVSYEP ITTTLKRKQE DVSATVIQRA YRRYRLRQNV KNISSIYIKD
     GDRDTNATSS ATSPPSYDDR TEKEDKGKDS KESKK
//
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