ID H2PC91_PONAB Unreviewed; 554 AA.
AC H2PC91;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 2.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=Insulin like growth factor 2 mRNA binding protein 2 {ECO:0000313|Ensembl:ENSPPYP00000016078.3};
GN Name=IGF2BP2 {ECO:0000313|Ensembl:ENSPPYP00000016078.3};
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000016078.3, ECO:0000313|Proteomes:UP000001595};
RN [1] {ECO:0000313|Ensembl:ENSPPYP00000016078.3, ECO:0000313|Proteomes:UP000001595}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Wilson R.K., Mardis E.;
RT "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPPYP00000016078.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, P-body
CC {ECO:0000256|ARBA:ARBA00004201}. Cytoplasm, Stress granule
CC {ECO:0000256|ARBA:ARBA00004210}.
CC -!- SIMILARITY: Belongs to the RRM IMP/VICKZ family.
CC {ECO:0000256|ARBA:ARBA00009094}.
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DR Ensembl; ENSPPYT00000016722.3; ENSPPYP00000016078.3; ENSPPYG00000014373.3.
DR eggNOG; KOG2193; Eukaryota.
DR GeneTree; ENSGT00940000154913; -.
DR HOGENOM; CLU_020744_0_0_1; -.
DR InParanoid; H2PC91; -.
DR TreeFam; TF320229; -.
DR Proteomes; UP000001595; Chromosome 3.
DR GO; GO:0010494; C:cytoplasmic stress granule; IEA:UniProtKB-SubCell.
DR GO; GO:0000932; C:P-body; IEA:UniProtKB-SubCell.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR CDD; cd22491; KH-I_IGF2BP2_rpt1; 1.
DR CDD; cd22494; KH-I_IGF2BP2_rpt2; 1.
DR CDD; cd22497; KH-I_IGF2BP2_rpt3; 1.
DR CDD; cd12626; RRM1_IGF2BP2; 1.
DR CDD; cd12629; RRM2_IGF2BP2; 1.
DR Gene3D; 3.30.310.210; -; 1.
DR Gene3D; 3.30.70.330; -; 2.
DR Gene3D; 3.30.1370.10; K Homology domain, type 1; 2.
DR InterPro; IPR034843; IGF2BP2_RRM1.
DR InterPro; IPR004087; KH_dom.
DR InterPro; IPR004088; KH_dom_type_1.
DR InterPro; IPR036612; KH_dom_type_1_sf.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR PANTHER; PTHR10288:SF93; INSULIN-LIKE GROWTH FACTOR 2 MRNA-BINDING PROTEIN 2; 1.
DR PANTHER; PTHR10288; KH DOMAIN CONTAINING RNA BINDING PROTEIN; 1.
DR Pfam; PF00013; KH_1; 4.
DR Pfam; PF00076; RRM_1; 2.
DR SMART; SM00322; KH; 4.
DR SMART; SM00360; RRM; 2.
DR SUPFAM; SSF54791; Eukaryotic type KH-domain (KH-domain type I); 4.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
DR PROSITE; PS50084; KH_TYPE_1; 4.
DR PROSITE; PS50102; RRM; 2.
PE 3: Inferred from homology;
KW mRNA transport {ECO:0000256|ARBA:ARBA00022816};
KW Reference proteome {ECO:0000313|Proteomes:UP000001595};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00176};
KW Translation regulation {ECO:0000256|ARBA:ARBA00022845};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 3..76
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 82..157
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT REGION 156..188
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 554 AA; 61114 MW; 5377A1436DE0A25E CRC64;
MMNKLYIGNL SPAVTVDDLR QLFGDRKLPL AGQVLLKSGY AFVDYPDQNW AIRAIETLSG
KVELHGKIME VDYSVSKKLR SRKIQIRNIP PHLQWEVLDG LLAQYGTVEN VEQVNTDTET
AVVNVTYARR EEAKIAVEKL SGHQFENYSF KISYIPDEEV SSPSPPQRAQ RGDHSSREQG
HAPGGTSQAR QIDFPLRILV PTQFVGAIIG KEGLTIKNIT KQTQSRVDIH RKENSGAAEK
PVTIHATPEG TSEACRMILE IMQKEADETK LAEEIPLKIL AHNGLVGRLI GKEGRNLKKI
EHETGTKITI SSLQDLSIYN PERTITVKGT VEACASAEIE IMKKLREAFE NDMLAVNTHS
GYFSSLYPHH QFGPFPHHHS YPEQEIVNLF IPTQAVGAII GKKGAHIKQL ARFAGASIKI
APAEGPDVSE RMVIITGPPE AQFKAQGRIF GKLKEENFFN PKEEVKLEAH IRVPSSTAGR
VIGKGGKTVN ELQNLTSAEV IVPRDQTPDE NEEVIVRIIG HFFASQCPGN VSEQPVPTGV
QSAGSCLQGQ CWAG
//
