ID   H2PCH7_PONAB            Unreviewed;       801 AA.
AC   H2PCH7;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   25-MAY-2022, sequence version 3.
DT   27-MAR-2024, entry version 58.
DE   SubName: Full=Leucine rich repeats and calponin homology domain containing 3 {ECO:0000313|Ensembl:ENSPPYP00000016168.3};
GN   Name=LRCH3 {ECO:0000313|Ensembl:ENSPPYP00000016168.3};
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000016168.3, ECO:0000313|Proteomes:UP000001595};
RN   [1] {ECO:0000313|Proteomes:UP000001595}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Wilson R.K., Mardis E.;
RT   "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
RL   Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSPPYP00000016168.3}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   AlphaFoldDB; H2PCH7; -.
DR   Ensembl; ENSPPYT00000016815.3; ENSPPYP00000016168.3; ENSPPYG00000014457.3.
DR   eggNOG; KOG0532; Eukaryota.
DR   GeneTree; ENSGT00940000158330; -.
DR   HOGENOM; CLU_008231_2_0_1; -.
DR   InParanoid; H2PCH7; -.
DR   OMA; LYSWIFP; -.
DR   TreeFam; TF318428; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0032185; P:septin cytoskeleton organization; IEA:Ensembl.
DR   Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR   InterPro; IPR001715; CH_dom.
DR   InterPro; IPR036872; CH_dom_sf.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   PANTHER; PTHR48051; -; 1.
DR   PANTHER; PTHR48051:SF44; LEUCINE RICH REPEATS AND CALPONIN HOMOLOGY DOMAIN CONTAINING 3; 1.
DR   Pfam; PF00307; CH; 1.
DR   Pfam; PF13855; LRR_8; 2.
DR   SMART; SM00033; CH; 1.
DR   SMART; SM00364; LRR_BAC; 5.
DR   SMART; SM00369; LRR_TYP; 5.
DR   SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR   SUPFAM; SSF52058; L domain-like; 1.
DR   PROSITE; PS50021; CH; 1.
PE   4: Predicted;
KW   Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001595};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        776..797
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          650..765
FT                   /note="Calponin-homology (CH)"
FT                   /evidence="ECO:0000259|PROSITE:PS50021"
FT   REGION          511..547
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          562..589
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          619..649
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        574..589
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   801 AA;  89185 MW;  488B2BB2C69F88EA CRC64;
     MAAAGLVAVA AAAEYSGTVA SGGNLPGVHC GPSSGAGPGF GPGSWSRSLD RALEEASVTG
     VLSLSGRKLR EFPRGAANHD LTDTTRADLS RNRLSEIPIE ACHFVSLENL NLYQNCIRYI
     PEAILNLQAL TFLNISRNQL STLPVHLCNL PLKVLIASNN KLVSLPEEIG HLRHLMELDV
     SCNEIQTIPS QIGNLESLRD LNVRRNHLVH LPEELAELPL IRLDFSCNKI TTIPVCYRNL
     RHLQTITLDN NPLQSPPAQI CIKGKIHIFK YLNIQACKIA PDLPDYDRRP LGFGSCHEEL
     YSSRPYGALD SGFNSVDSGD KRWSGNEPTD EFSDLPLRVA EITKEQRLRR ESQYQENRGS
     LVVTNGGVEH DLDQIDYIDS CTAEEEEAEV RQPKGPDSDS LSSQFMAYIE QRRISHEGSP
     VKPVAIREFQ KTEDMRRYLH QNRVPVEPSS LLSLSASHNQ LSHTDLELHR RREQLVERTR
     REAQLAALQY EEEKIRTKQI QRDAVLDFVK QKASQSPQKQ HPLLDGVDGE CPFPSRRSQH
     TDDSTLSLSG LNQVGCAATL PHSSAFTPRK SDDRPNALLS SPTTETVHHS PAYSFPAAIQ
     RNQPQRPESF LFRAGVRAET NKGHASPLPP SAAPTTDPTD SITRQNSRQR EEELKLIDQL
     RKHIEYRLKV SLPCDLGAAL TDGVVLCHLA NHVRPRSVPS IHVPSPAVPK LTMAKCRRNV
     ENFLEACRKI GVPQDNLCSP SDILQLNLSV KRTVETLLSL GAHSEESSFV CLSLQLLGFV
     AFYCTVMLTL CVLYYWLFPA R
//