ID H2PGQ4_PONAB Unreviewed; 602 AA.
AC H2PGQ4; A0A2J8VPL4;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 2.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=SLC23A1 isoform 4 {ECO:0000313|EMBL:PNJ59458.1};
DE SubName: Full=Solute carrier family 23 member 1 {ECO:0000313|Ensembl:ENSPPYP00000017709.3};
GN Name=SLC23A1 {ECO:0000313|Ensembl:ENSPPYP00000017709.3};
GN ORFNames=CR201_G0017499 {ECO:0000313|EMBL:PNJ59458.1};
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000017709.3, ECO:0000313|Proteomes:UP000001595};
RN [1] {ECO:0000313|Ensembl:ENSPPYP00000017709.3, ECO:0000313|Proteomes:UP000001595}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Wilson R.K., Mardis E.;
RT "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:PNJ59458.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Susie {ECO:0000313|EMBL:PNJ59458.1};
RA Pollen A., Hastie A., Hormozdiari F., Dougherty M., Liu R., Chaisson M.,
RA Hoppe E., Hill C., Pang A., Hillier L., Baker C., Armstrong J.,
RA Shendure J., Paten B., Wilson R., Chao H., Schneider V., Ventura M.,
RA Kronenberg Z., Murali S., Gordon D., Cantsilieris S., Munson K., Nelson B.,
RA Raja A., Underwood J., Diekhans M., Fiddes I., Haussler D., Eichler E.;
RT "High-resolution comparative analysis of great ape genomes.";
RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSPPYP00000017709.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC
CC 2.A.40) family. {ECO:0000256|ARBA:ARBA00008821}.
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DR EMBL; NDHI03003414; PNJ59458.1; -; Genomic_DNA.
DR Ensembl; ENSPPYT00000018422.3; ENSPPYP00000017709.3; ENSPPYG00000015837.3.
DR eggNOG; KOG1292; Eukaryota.
DR GeneTree; ENSGT00950000182953; -.
DR HOGENOM; CLU_017959_5_4_1; -.
DR OMA; AHANSEM; -.
DR OrthoDB; 911690at2759; -.
DR TreeFam; TF313272; -.
DR Proteomes; UP000001595; Chromosome 5.
DR GO; GO:0016324; C:apical plasma membrane; IEA:Ensembl.
DR GO; GO:0009925; C:basal plasma membrane; IEA:Ensembl.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0043229; C:intracellular organelle; IEA:Ensembl.
DR GO; GO:0033300; F:dehydroascorbic acid transmembrane transporter activity; IEA:Ensembl.
DR GO; GO:0008520; F:L-ascorbate:sodium symporter activity; IEA:Ensembl.
DR GO; GO:0015229; F:L-ascorbic acid transmembrane transporter activity; IEA:Ensembl.
DR GO; GO:0015143; F:urate transmembrane transporter activity; IEA:Ensembl.
DR GO; GO:0007420; P:brain development; IEA:Ensembl.
DR GO; GO:0030324; P:lung development; IEA:Ensembl.
DR GO; GO:0009636; P:response to toxic substance; IEA:Ensembl.
DR InterPro; IPR006043; NCS2.
DR PANTHER; PTHR11119:SF21; SOLUTE CARRIER FAMILY 23 MEMBER 1; 1.
DR PANTHER; PTHR11119; XANTHINE-URACIL / VITAMIN C PERMEASE FAMILY MEMBER; 1.
DR Pfam; PF00860; Xan_ur_permease; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001595};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 40..66
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 78..100
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 156..177
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 215..233
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 253..276
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 403..425
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 431..450
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 462..479
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 495..515
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..15
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 602 AA; 65138 MW; 50060AE737469F17 CRC64;
MRAQEDPEGR TQHESTRDPP TPLPTEPKFD MLYKIEDVPP WYLCILLGFQ HYLTCFSGTI
AVPFLLAEAL CVGHDQHMVS QLIGTIFTCV GITTLIQTTL GIRLPLFQAS AFAFLVPAKA
ILALERWKCP PEEEIYGNWS LPLNTSHIWH PRIREVGLHV QGAIMVSSVV EVVIGLLGLP
GALLNYIGPL TVTPTVSLIG LSVFQAAGDR AGSHWGISAC SILLIILFSQ YLRNLTFLLP
VYRWGKGLTL LRIQIFKMFP IVLAIMTVWL LCYVLTLTDV LPADPKAYGF QARTDARGDI
MAIAPWIRIP YPCQWGLPTV TAAAVLGMFS ATLAGIIESI GDYYACARLA GAPPPPVHAI
NRGIFTEGIC CIIAGLLGTG NGSTSSSPNI GVLGITKVGS RRVVQYGAAI MLVLGTIGKF
TALFASLPDP ILGGMFCTLF GMITAVGLSN LQFVDMNSSR NLFVLGFSMF FGLTLPNYLE
SNPGAINTGI LEVDQILTVL LTTEMFVGGC LAFILDNTVP GSPEERGLIQ WKAGAHANSD
MSSSLKSYDF PIGMGIVKRI AFLKYIPICP VFKGFSLSSK DQIAIPEDTP ENTETASVCT
KV
//
