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Database: UniProt
Entry: H2PIQ8_PONAB
LinkDB: H2PIQ8_PONAB
Original site: H2PIQ8_PONAB 
ID   H2PIQ8_PONAB            Unreviewed;      2641 AA.
AC   H2PIQ8;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   30-AUG-2017, entry version 31.
DE   SubName: Full=Inositol 1,4,5-trisphosphate receptor type 3 {ECO:0000313|Ensembl:ENSPPYP00000018459};
GN   Name=ITPR3 {ECO:0000313|Ensembl:ENSPPYP00000018459};
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Pongo.
OX   NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000018459, ECO:0000313|Proteomes:UP000001595};
RN   [1] {ECO:0000313|Ensembl:ENSPPYP00000018459, ECO:0000313|Proteomes:UP000001595}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Wilson R.K., Mardis E.;
RT   "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
RL   Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSPPYP00000018459}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSPPYP00000018459}.
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DR   EMBL; ABGA01022633; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABGA01022634; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABGA01022635; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABGA01022636; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABGA01022637; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABGA01022638; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABGA01022639; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABGA01022640; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABGA01022641; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9601.ENSPPYP00000018459; -.
DR   Ensembl; ENSPPYT00000019194; ENSPPYP00000018459; ENSPPYG00000016504.
DR   eggNOG; KOG3533; Eukaryota.
DR   eggNOG; ENOG410XR97; LUCA.
DR   GeneTree; ENSGT00760000119152; -.
DR   InParanoid; H2PIQ8; -.
DR   OMA; VVVFYND; -.
DR   OrthoDB; EOG091G00T2; -.
DR   TreeFam; TF312815; -.
DR   Proteomes; UP000001595; Chromosome 6.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:Ensembl.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:Ensembl.
DR   GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0043235; C:receptor complex; IEA:Ensembl.
DR   GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; IEA:Ensembl.
DR   GO; GO:0005220; F:inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; IEA:Ensembl.
DR   GO; GO:0035091; F:phosphatidylinositol binding; IEA:Ensembl.
DR   GO; GO:0060291; P:long-term synaptic potentiation; IEA:Ensembl.
DR   GO; GO:0007613; P:memory; IEA:Ensembl.
DR   GO; GO:0051592; P:response to calcium ion; IEA:Ensembl.
DR   GO; GO:0050913; P:sensory perception of bitter taste; IEA:Ensembl.
DR   GO; GO:0050916; P:sensory perception of sweet taste; IEA:Ensembl.
DR   GO; GO:0050917; P:sensory perception of umami taste; IEA:Ensembl.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR000493; InsP3_rcpt-bd.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   PRINTS; PR00779; INSP3RECEPTR.
DR   SMART; SM00472; MIR; 4.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001595};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001595};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2171   2196       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2208   2226       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2238   2258       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2294   2319       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2339   2361       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2468   2491       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       83    143       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      144    194       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      202    258       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      265    342       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      348    404       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   COILED     2599   2626       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2641 AA;  301066 MW;  CBE77F2A9BD60C66 CRC64;
     LVDDRCVVEP AAGDLDNPPK KFRDCLFKVC PMNRYSAQKQ YWKAKQTKQD KEKIADVVLL
     QKLQHAAQME QKQNDTENKK VHGDVVKYGS VIQLLHMKSN KYLTVNKRLP ALLEKNAMRV
     TLDATGNEGS WLFIQPFWKL RSNGDNVVVG DKVILNPVNA GQPLHASNYE LSDNAGCKEV
     NSVNCNTSWK INLFMQFRDH LEEVLKGGDV VRLFHAEQEK FLTCDEYKGK LQVFLRTTLR
     QSATSATSSN ALWEVEVVHH DPCRGGAGHW NGLYRFKHLA TGNYLAAEEN PSYKGDASDP
     KAAGMGAQGR AGRRNAGEKI KYRLVAVPHG NDIASLFELD PTTLQKTDSF VPRNSYVRLR
     HLCTNTWIQS TNVPIDIEEE RPIRLMLGTC PTKEDKEAFA IVSVPVSEIR DLDFANDASS
     MLASAVEKLN EGFISQNDRR FVIQLLEDLV FFVSDVPNNG QNVLDIMVTK PNRERQKLMR
     EQNILKQIFG ILKAPFREKG SEGPLVRLEE LSDQKNAPYQ HMFRLCYRVL RHSQEDYRKN
     QEHIAKQFGM MQSQIGYDIL AEDTITALLH NNRKLLEKHI TKTEVETFVS LVRKNREPRF
     LDYLSDLCVS NHIAIPVTQE LICKCVLDPK NSDILIRTEL RPVKEMAQSH EYLSIEYSEE
     EVWLTWTDKN NEHHEKSVRQ LAQEARAGNA HDENVLSYYR YQLKLFARMC LDRQYLAIDE
     ISQQLGVDLI FLCMADEMLP FDLRASFCHL MLHVHVDRDP QELVTPVKFA RLWTEIPTAI
     TIKDYDSNLN ASRDDKKNKF ANTMEFVEDY LNNVVSEAVP FANEEKNKLT FEVVSLAHNL
     IYFGFYSFSE LLRLTRTLLG IIDCVQGPPA MLQAYEEPGG KNVRRSIQGV GHMMSTMVLS
     RKQSVFSAPS MSAGASAAEP LDRSKFEENE DIVVMETKLK ILEILQFILN VRLDYRISYL
     LSVFKKEFVE VFPMQDSGAD GTAPAFDSTT ANMNLDRIGE QAEAMFGVGK TSSMLEVDDE
     GGRMFLRVLI HLTMHDYAPL VSGALQLLFK HFSQRQEAMH TFKQVQLLIS AQDVENYKVI
     KSELDRLRTM VEKSELWVDK KGSGKGEEVE AGAAKDKKER PTDEEGFLHP PGEKSSENYQ
     IVKGILERLN KMCGVGEQMR KKQQRLLKNM DAHKVMLDLL QIPYDKGDAK MMEILRYTHQ
     FLQKFCAGNP GNQALLHKHL HLFLTPGLLE AETMQHIFLN NYQLCSEISE PVLQHFVHLL
     ATHGRHVQYL DFLHTVIKAE GKYVKKCQDM IMTELTNAGD DVVVFYNDKA SLAHLLDMMK
     AARDGVEDHS PLMYHISLVD LLAACAEGKN VYTEIKCTSL LPLEDVVSVV THEDCITEVK
     MAYVNFVNHC YVDTEVEMKE IYTSNHILTL IESFTLDMAR VCSKREKRVA DPTLEKYVLS
     VVLDTINAFF SSPFSENSTS LQTHQTIVVQ LLQSTTRLLE CPWLQQQHKG SVEACIRTLA
     MVAKGRAILL PMDLDAHISS MLSSGASCAA AAQRNASSYK ATTRAFPRVT PTANQWDYKN
     IIEKLQDIIT ALEERLKPLV QAELSVLVDV LHWPELLFLE GSEAYQRCES GGFLSKLIQH
     TKDLMESEEK LCIKVLRTLQ QMLLKKTKYG DRGNQLRKML LQNYLQNRKS TSRGDLPDPM
     GTGLDPDWSA IAATQCRLDK EGATKLVCDL ITSTKNEKIF QESIGLAIRL LDGGNTEIQK
     SFHNLMMSDK KSERFFKVLH DRMKRAQQET KSTVAVNMND LGSQPHEDRE PVDPTTKGRV
     ASFSIPGSSS RYSLGPSLRR GHEVSERVQS NEMGTSVLIM QPILRFLQLL CENHNRDLQN
     FLRCQNNKTN YNLVCETLQF LDIMCGSTTG GLGLLGLYIN EDNVGLVIQT LETLTEYCQG
     PCHENQTCIV THESNGIDII TALILNDISP LCKYRMDLVL QLKDNASKLL LALMESRHDR
     ENAERILINM RPQELVDVIK KAYLQEEERE NSEVSPREVG HNIYILALQL SRHNKQLQHL
     LKPVKRIQEE EAEGISSMLS LNNKQLSQML KSSVPAQEEE EDPLAYYENH TSQIEIVRQD
     RSMEQIVFPV PGICQFLTEE TKHRLFTTTE QDEQGSKVSD FFDQSSFLHN EMEWQRKLRS
     MPLIYWFSRR MTLWGSISFN LAVFINIIIA FFYPYMEGAS TGVLDSPLIS LLFWILICFS
     IAALFTKRYS IRPLIVALIL RSIYYLGIGP TLNILGALNL TNKIVFVVSF VGNRGTFIRG
     YKAMVMDMEF LYHVGYILTS VLGLFAHELF YSILLFDLIY REETLFNVIK SVTRNGRSIL
     LTALLALILV YLFSIVGFLF LKDDFILEVD RLPNNHSTVS PLGMPHGAAA FVDTCSGDKM
     DCVSGVSVPE VLEEDGELDS TERACDTLLM CIVTVMNHGL RNGGGVGDIL RKPSKDESLF
     PARVVYDLLF FFIVIIIVLN LIFGVIIDTF ADLRSEKQKK EEILKTTCFI CGLERDKFDN
     KTVSFEEHIK LEHNMWNYLY FIVLVRVKNK TDYTGPESYV AQMIKNKNLD WFPRMRAMSL
     VSNEGEGEQN EIRILQDKLN STMKLVSHLT AQLNELKEQM TEQRKRRQRL GFVDVQNCMS
     R
//
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