ID H2PNW5_PONAB Unreviewed; 307 AA.
AC H2PNW5; A0A2J8V2R2;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 2.
DT 27-MAR-2024, entry version 57.
DE RecName: Full=Taste receptor type 2 {ECO:0000256|RuleBase:RU004424};
GN Name=TAS2R41 {ECO:0000313|Ensembl:ENSPPYP00000020331.2};
GN ORFNames=CR201_G0022694 {ECO:0000313|EMBL:PNJ51818.1};
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000020331.2, ECO:0000313|Proteomes:UP000001595};
RN [1] {ECO:0000313|Ensembl:ENSPPYP00000020331.2, ECO:0000313|Proteomes:UP000001595}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Wilson R.K., Mardis E.;
RT "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:PNJ51818.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Susie {ECO:0000313|EMBL:PNJ51818.1};
RA Pollen A., Hastie A., Hormozdiari F., Dougherty M., Liu R., Chaisson M.,
RA Hoppe E., Hill C., Pang A., Hillier L., Baker C., Armstrong J.,
RA Shendure J., Paten B., Wilson R., Chao H., Schneider V., Ventura M.,
RA Kronenberg Z., Murali S., Gordon D., Cantsilieris S., Munson K., Nelson B.,
RA Raja A., Underwood J., Diekhans M., Fiddes I., Haussler D., Eichler E.;
RT "High-resolution comparative analysis of great ape genomes.";
RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSPPYP00000020331.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Receptor that may play a role in the perception of bitterness
CC and is gustducin-linked. May play a role in sensing the chemical
CC composition of the gastrointestinal content. The activity of this
CC receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation
CC and lead to the gating of TRPM5. {ECO:0000256|ARBA:ARBA00024847}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU004424}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU004424}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor T2R family.
CC {ECO:0000256|ARBA:ARBA00007376, ECO:0000256|RuleBase:RU004423}.
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DR EMBL; NDHI03003435; PNJ51818.1; -; Genomic_DNA.
DR STRING; 9601.ENSPPYP00000020331; -.
DR Ensembl; ENSPPYT00000021128.2; ENSPPYP00000020331.2; ENSPPYG00000018122.2.
DR eggNOG; ENOG502S2SI; Eukaryota.
DR GeneTree; ENSGT01100000263477; -.
DR HOGENOM; CLU_072337_1_1_1; -.
DR OMA; LHWDFLN; -.
DR OrthoDB; 4642354at2759; -.
DR TreeFam; TF335891; -.
DR Proteomes; UP000001595; Chromosome 7.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR GO; GO:0033038; F:bitter taste receptor activity; IEA:InterPro.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR CDD; cd15018; 7tm_TAS2R41-like; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR007960; TAS2R.
DR PANTHER; PTHR11394; TASTE RECEPTOR TYPE 2; 1.
DR PANTHER; PTHR11394:SF73; TASTE RECEPTOR TYPE 2 MEMBER 41; 1.
DR Pfam; PF05296; TAS2R; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
PE 3: Inferred from homology;
KW G-protein coupled receptor {ECO:0000256|RuleBase:RU004424};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU004424};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU004424};
KW Reference proteome {ECO:0000313|Proteomes:UP000001595};
KW Sensory transduction {ECO:0000256|ARBA:ARBA00022606,
KW ECO:0000256|RuleBase:RU004424};
KW Taste {ECO:0000256|ARBA:ARBA00022480, ECO:0000256|RuleBase:RU004424};
KW Transducer {ECO:0000256|ARBA:ARBA00023224, ECO:0000256|RuleBase:RU004424};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU004424};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 6..32
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 44..68
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 88..109
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 129..151
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 186..204
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 236..258
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 270..288
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 307 AA; 36113 MW; 75E51994ECD31E57 CRC64;
MQAALTAFFM LFFSLLSLLG IAANGFIVLV LGREWLQYGR LLPLDMILIS LGVSRFCLQL
VGTVYNFYYS AHKVEYSGGL SRQFFHLHWH FLNLATFWFC SWLSVLFCVK TANITHPTFL
WLKWRFPGWV PWLLLGSVLI SFIITLLLFW VNYPVYQEFL IRKFSGNMTY EWNTRIEMYY
LPSLKLVIWS IPCSVFLVSI MLLINSLRRH TWRMQHNGHS LQDPSTQAHT RALKSLISFL
ILYVLSFLSL IIDATKFISM QNDFYWPWQT AVYLGVSVHP FILIFSNLKL RSVFWKLLLL
ARGFWVA
//
