ID H2PP46_PONAB Unreviewed; 864 AA.
AC H2PP46; A0A2J8TDY4;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 2.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=Dipeptidyl aminopeptidase-like protein 6 {ECO:0000256|ARBA:ARBA00040948};
DE AltName: Full=Dipeptidyl peptidase 6 {ECO:0000256|ARBA:ARBA00042016};
DE AltName: Full=Dipeptidyl peptidase VI {ECO:0000256|ARBA:ARBA00041991};
GN Name=DPP6 {ECO:0000313|Ensembl:ENSPPYP00000020414.3};
GN ORFNames=CR201_G0035688 {ECO:0000313|EMBL:PNJ31189.1};
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000020414.3, ECO:0000313|Proteomes:UP000001595};
RN [1] {ECO:0000313|Ensembl:ENSPPYP00000020414.3, ECO:0000313|Proteomes:UP000001595}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Wilson R.K., Mardis E.;
RT "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:PNJ31189.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Susie {ECO:0000313|EMBL:PNJ31189.1};
RA Pollen A., Hastie A., Hormozdiari F., Dougherty M., Liu R., Chaisson M.,
RA Hoppe E., Hill C., Pang A., Hillier L., Baker C., Armstrong J.,
RA Shendure J., Paten B., Wilson R., Chao H., Schneider V., Ventura M.,
RA Kronenberg Z., Murali S., Gordon D., Cantsilieris S., Munson K., Nelson B.,
RA Raja A., Underwood J., Diekhans M., Fiddes I., Haussler D., Eichler E.;
RT "High-resolution comparative analysis of great ape genomes.";
RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSPPYP00000020414.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; NDHI03003505; PNJ31189.1; -; Genomic_DNA.
DR STRING; 9601.ENSPPYP00000020414; -.
DR Ensembl; ENSPPYT00000021221.3; ENSPPYP00000020414.3; ENSPPYG00000018209.3.
DR eggNOG; KOG2100; Eukaryota.
DR GeneTree; ENSGT00940000156280; -.
DR OMA; GERYMDT; -.
DR OrthoDB; 2876738at2759; -.
DR TreeFam; TF313309; -.
DR Proteomes; UP000001595; Chromosome 7.
DR GO; GO:0008076; C:voltage-gated potassium channel complex; IEA:Ensembl.
DR GO; GO:0015459; F:potassium channel regulator activity; IEA:Ensembl.
DR GO; GO:0008236; F:serine-type peptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR GO; GO:1901379; P:regulation of potassium ion transmembrane transport; IEA:Ensembl.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 2.140.10.30; Dipeptidylpeptidase IV, N-terminal domain; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR001375; Peptidase_S9.
DR InterPro; IPR002469; Peptidase_S9B_N.
DR PANTHER; PTHR11731:SF20; DIPEPTIDYL AMINOPEPTIDASE-LIKE PROTEIN 6; 1.
DR PANTHER; PTHR11731; PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED; 1.
DR Pfam; PF00930; DPPIV_N; 1.
DR Pfam; PF00326; Peptidase_S9; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF82171; DPP6 N-terminal domain-like; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001595};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 95..116
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 194..560
FT /note="Dipeptidylpeptidase IV N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00930"
FT DOMAIN 641..847
FT /note="Peptidase S9 prolyl oligopeptidase catalytic"
FT /evidence="ECO:0000259|Pfam:PF00326"
FT REGION 1..87
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..20
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 864 AA; 97783 MW; 5C9B67FB58853CBC CRC64;
MASLYQRFTG KINTSRSFPA PPEASHLLGG QGPEEDGGAG AKPLGPRAQA VAPRERGGRG
GAGGRPRFQY QARSDGDEED ELVGSNPPQR NWKGIAIALL VILVICSLIV TSVILLTPAE
DNSLSQKKKV TVEDLFSEDF KIHDPEAKWI SDTEFIYREQ KGTVRLWNVE TNTSTVLIEG
KKIESLRAVR YEISPDREYA LFSYNVEPIY QYSYTGYYVL SKIPHGDPQS LDPPEVNNAK
LQYAGWGPKG QQLIFIFENN IYYCAHVGKQ AIRVVSTGKE GVIYNGLSDW LYEEEILKTH
IAHWWSPDGT RLAYATINDS RVPIMELPTY TGSIYPTVKP YHYPKAGSEN PTISLHVIGL
SGPTHDLEMM PPDDPRMREY YITMVKWATS TKVAVTWLNR AQNVSILTLC DATTGVCTKK
HEDESEAWLH RQNEEPVFSK DGRKFFFIRA IPQGGRGKFY HITVSSSQPN SSNDNIQSIT
SGDWDVTKIL AYDEKGNKIY FLSTEDLPRR RQLYSANTVG NFNRQCLSCD LVENCTYFSA
SFSHSMDFFL LKCEGPGVPM MTVHNTTDKK KIFDLETNEH VKKAINDRQM PKVEYRNIEI
DDYNLPMQIL KPATFTDTTH YPLLLVVDGT PGSQSVAEKF EVSWETVMIS SYGTVVVKCD
GRGSGFQGTK LLHEVRRRLG LLEEKDQMEA VRTMLKEQYI DKTRVAVFGK DYGGYLSTYI
LPAKGENQGQ TFTCGSALSP ITDFKLYASA FSERYLGLHG LDNRAYEMTK VAHRVSALEE
QQFLIIHPTA DEKIHFQHTA ELITQLIRGK TNYSLQIYPD ESHYFTSSSL KQHLYRSIIN
FFVECFRIQD KLPTVTAKED EEED
//
