ID H2PST1_PONAB Unreviewed; 310 AA.
AC H2PST1; A0A2J8WNM2; A0A663DF36;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=17beta-estradiol 17-dehydrogenase {ECO:0000256|ARBA:ARBA00024072};
DE EC=1.1.1.62 {ECO:0000256|ARBA:ARBA00024072};
GN Name=HSD17B3 {ECO:0000313|Ensembl:ENSPPYP00000021754.2};
GN ORFNames=CR201_G0008819 {ECO:0000313|EMBL:PNJ71361.1};
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000021754.2, ECO:0000313|Proteomes:UP000001595};
RN [1] {ECO:0000313|Ensembl:ENSPPYP00000021754.2, ECO:0000313|Proteomes:UP000001595}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Wilson R.K., Mardis E.;
RT "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:PNJ71361.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Susie {ECO:0000313|EMBL:PNJ71361.1};
RA Pollen A., Hastie A., Hormozdiari F., Dougherty M., Liu R., Chaisson M.,
RA Hoppe E., Hill C., Pang A., Hillier L., Baker C., Armstrong J.,
RA Shendure J., Paten B., Wilson R., Chao H., Schneider V., Ventura M.,
RA Kronenberg Z., Murali S., Gordon D., Cantsilieris S., Munson K., Nelson B.,
RA Raja A., Underwood J., Diekhans M., Fiddes I., Haussler D., Eichler E.;
RT "High-resolution comparative analysis of great ape genomes.";
RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSPPYP00000021754.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC family. 17-beta-HSD 3 subfamily. {ECO:0000256|ARBA:ARBA00038261}.
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DR EMBL; NDHI03003383; PNJ71361.1; -; Genomic_DNA.
DR RefSeq; XP_002820038.1; XM_002819992.3.
DR STRING; 9601.ENSPPYP00000021754; -.
DR Ensembl; ENSPPYT00000022644.3; ENSPPYP00000021754.2; ENSPPYG00000019414.3.
DR GeneID; 100433175; -.
DR KEGG; pon:100433175; -.
DR CTD; 3293; -.
DR eggNOG; KOG1014; Eukaryota.
DR GeneTree; ENSGT00940000160266; -.
DR HOGENOM; CLU_010194_38_0_1; -.
DR OMA; CNIISVT; -.
DR OrthoDB; 6845at2759; -.
DR TreeFam; TF314591; -.
DR Proteomes; UP000001595; Chromosome 9.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl.
DR GO; GO:0047045; F:testosterone 17-beta-dehydrogenase (NADP+) activity; IEA:Ensembl.
DR GO; GO:0006694; P:steroid biosynthetic process; IEA:UniProtKB-KW.
DR CDD; cd05356; 17beta-HSD1_like_SDR_c; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020904; Sc_DH/Rdtase_CS.
DR InterPro; IPR002347; SDR_fam.
DR PANTHER; PTHR43899:SF7; 17-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 3; 1.
DR PANTHER; PTHR43899; RH59310P; 1.
DR Pfam; PF00106; adh_short; 1.
DR PIRSF; PIRSF000126; 11-beta-HSD1; 1.
DR PRINTS; PR00081; GDHRDH.
DR PRINTS; PR00080; SDRFAMILY.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00061; ADH_SHORT; 1.
PE 3: Inferred from homology;
KW Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022955};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022955};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000001595};
KW Steroid biosynthesis {ECO:0000256|ARBA:ARBA00022955}.
SQ SEQUENCE 310 AA; 34630 MW; 4C88DBAF2C0C8A8B CRC64;
MGDVLEQFFI LTGLLVCLAC LAKCMRFSRC ILLNYWKVLP KPFLRSMGQW AVITGAGDGI
GKAYSFELAK RGLNVVLISR TLEKLEAIAT EIERTTGRSV KIIQADFTKD DIYEHIKEKL
TGLEIGILVN NVGMLPNLLP SHFLNAPDEI QSLIHCNITS VVKMTQLILK HMESRRKGLI
LNISSGIALF PWPLYSMYSA SKAFVCAFSK ALQEEYKAKE VIIQVLTPYA VSTAMTKYLN
TNVITKTADE FVKESLNYVT IGGETCGCLA HEILAGFLSL IPAWAFYSGA FQRLLLTHYV
AYLKLNTKVR
//
