ID H2PZE0_PANTR Unreviewed; 362 AA.
AC H2PZE0; A0A2J8MH96;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=Epoxide hydrolase 4 {ECO:0000313|Ensembl:ENSPTRP00000001645.5};
GN Name=EPHX4 {ECO:0000313|Ensembl:ENSPTRP00000001645.5,
GN ECO:0000313|VGNC:VGNC:10613};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000001645.5, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000001645.5, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000001645.5}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the AB hydrolase superfamily. Epoxide hydrolase
CC family. {ECO:0000256|ARBA:ARBA00038334}.
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DR EMBL; AACZ04027489; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_001152592.2; XM_001152592.4.
DR AlphaFoldDB; H2PZE0; -.
DR STRING; 9598.ENSPTRP00000001645; -.
DR MEROPS; S33.978; -.
DR PaxDb; 9598-ENSPTRP00000001645; -.
DR Ensembl; ENSPTRT00000001801.5; ENSPTRP00000001645.5; ENSPTRG00000000955.5.
DR GeneID; 739732; -.
DR KEGG; ptr:739732; -.
DR CTD; 253152; -.
DR VGNC; VGNC:10613; EPHX4.
DR eggNOG; KOG4178; Eukaryota.
DR GeneTree; ENSGT00940000156233; -.
DR HOGENOM; CLU_020336_7_3_1; -.
DR InParanoid; H2PZE0; -.
DR OMA; YRWMVRS; -.
DR OrthoDB; 2443908at2759; -.
DR TreeFam; TF314403; -.
DR Proteomes; UP000002277; Chromosome 1.
DR Bgee; ENSPTRG00000000955; Expressed in Brodmann (1909) area 10 and 12 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004301; F:epoxide hydrolase activity; IEA:UniProt.
DR GO; GO:0016787; F:hydrolase activity; IBA:GO_Central.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR000073; AB_hydrolase_1.
DR InterPro; IPR000639; Epox_hydrolase-like.
DR PANTHER; PTHR43329; EPOXIDE HYDROLASE; 1.
DR PANTHER; PTHR43329:SF2; EPOXIDE HYDROLASE 4; 1.
DR Pfam; PF00561; Abhydrolase_1; 1.
DR PRINTS; PR00111; ABHYDROLASE.
DR PRINTS; PR00412; EPOXHYDRLASE.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..43
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 94..339
FT /note="AB hydrolase-1"
FT /evidence="ECO:0000259|Pfam:PF00561"
SQ SEQUENCE 362 AA; 42314 MW; 734396DCADB64FF7 CRC64;
MARLRDCLPR LMLTLRSLLF WSLVYCYCGL CASIHLLKLL WSLGKGPAQT FRRPAREHPP
ACLSDSSLGT HCYVRIKDSG LRFHYVAAGE RGKPLMLLLH GFPEFWYSWR YQLREFKSEY
RVVALDLRGY GETDAPIHRQ NYKLDCLITD IKDILDSLGY SKCVLIGHDW GGMIAWLIAI
CYPEMVMKLI VINFPHPNVF TEYILRHPAQ LLKSSYYYFF QIPWFPEFMF SINDFKVLKH
LFTSHSTGIG RKGCQLTTED LEAYIYVFSQ PGALSGPINH YRNIFSCLPL KHHMVTTPTL
LLWGENDAFM EVEMAEVTKI YVKNYFRLTI LSEASHWLQQ DQPDIVNKLI WTFLKEETRK
KD
//
