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Database: UniProt
Entry: H2Q0Q4_PANTR
LinkDB: H2Q0Q4_PANTR
Original site: H2Q0Q4_PANTR 
ID   H2Q0Q4_PANTR            Unreviewed;      2312 AA.
AC   H2Q0Q4;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   27-SEP-2017, entry version 39.
DE   RecName: Full=Voltage-dependent R-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
GN   Name=CACNA1E {ECO:0000313|Ensembl:ENSPTRP00000002923};
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Pan.
OX   NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000002923, ECO:0000313|Proteomes:UP000002277};
RN   [1] {ECO:0000313|Ensembl:ENSPTRP00000002923, ECO:0000313|Proteomes:UP000002277}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16136131; DOI=10.1038/nature04072;
RG   Chimpanzee sequencing and analysis consortium;
RT   "Initial sequence of the chimpanzee genome and comparison with the
RT   human genome.";
RL   Nature 437:69-87(2005).
RN   [2] {ECO:0000313|Proteomes:UP000002277}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16136134; DOI=10.1038/nature04101;
RA   Hughes J.F., Skaletsky H., Pyntikova T., Minx P.J., Graves T.,
RA   Rozen S., Wilson R.K., Page D.C.;
RT   "Conservation of Y-linked genes during human evolution revealed by
RT   comparative sequencing in chimpanzee.";
RL   Nature 437:100-103(2005).
RN   [3] {ECO:0000313|Ensembl:ENSPTRP00000002923}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. The isoform alpha-1E
CC       gives rise to R-type calcium currents. R-type calcium channels
CC       belong to the 'high-voltage activated' (HVA) group and are blocked
CC       by nickel, and partially by omega-agatoxin-IIIA (omega-Aga-IIIA).
CC       They are however insensitive to dihydropyridines (DHP), omega-
CC       conotoxin-GVIA (omega-CTx-GVIA), and omega-agatoxin-IVA (omega-
CC       Aga-IVA). Calcium channels containing alpha-1E subunit could be
CC       involved in the modulation of firing patterns of neurons which is
CC       important for information processing.
CC       {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSPTRP00000002923}.
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DR   EMBL; AACZ03000417; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AACZ03000418; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AACZ03000419; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AACZ03000420; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AACZ03000421; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AACZ03000422; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AACZ03000423; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AACZ03000424; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AACZ03000425; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AACZ03011351; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9598.ENSPTRP00000002923; -.
DR   PaxDb; H2Q0Q4; -.
DR   Ensembl; ENSPTRT00000003175; ENSPTRP00000002923; ENSPTRG00000001749.
DR   eggNOG; ENOG410INF5; Eukaryota.
DR   eggNOG; ENOG410YD06; LUCA.
DR   GeneTree; ENSGT00830000128247; -.
DR   InParanoid; H2Q0Q4; -.
DR   OMA; RRRHHMS; -.
DR   OrthoDB; EOG091G0TKO; -.
DR   TreeFam; TF312805; -.
DR   Proteomes; UP000002277; Chromosome 1.
DR   Bgee; ENSPTRG00000001749; -.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0008331; F:high voltage-gated calcium channel activity; IBA:GO_Central.
DR   GO; GO:0086010; P:membrane depolarization during action potential; IBA:GO_Central.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR014873; VDCC_a1su_IQ.
DR   InterPro; IPR005449; VDCC_R_a1su.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   PANTHER; PTHR10037:SF253; PTHR10037:SF253; 1.
DR   Pfam; PF08763; Ca_chan_IQ; 1.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01633; RVDCCALPHA1.
DR   SMART; SM01062; Ca_chan_IQ; 1.
DR   PROSITE; PS50222; EF_HAND_2; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002277};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM     93    110       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    130    150       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    162    180       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    221    243       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    295    316       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    328    350       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    477    497       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    503    521       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    603    625       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    680    703       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1152   1171       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1224   1243       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1288   1310       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1400   1425       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1481   1499       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1511   1534       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1540   1558       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1605   1623       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1698   1722       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1738   1773       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED      699    726       {ECO:0000256|SAM:Coils}.
FT   COILED     1099   1121       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2312 AA;  261782 MW;  BE48BA5CE82318A9 CRC64;
     MARFGEAVVA RPGSGDGDSD QSRNRQGTPV PASGQAAAYK QTKAQRARTM ALYNPIPVRQ
     NCFTVNRSLF IFGEDNIVRK YAKKLIDWPP FEYMILATII ANCIVLALEQ HLPEDDKTPM
     SRRLEKTEPY FIGIFCFEAG IKIVALGFIF HKGSYLRNGW NVMDFIVVLS GILATAGTHF
     NTHVDLRTLR AVRVLRPLKL VSGIPSLQIV LKSIMKAMVP LLQIGLLLFF AILMFAIIGL
     EFYSGKLHRA CFMNNSGILE GFDPPHPCGV QGCPAGYECK DWIGPNDGIT QFDNILFAVL
     TVFQCITMEG WTTVLYNTND ALGATWNWLY FIPLIIIGSF FVLNLVLGVL SGEFAKERER
     VENRRAFMKL RRQQQIEREL NGYRAWIDKA EEVMLAEENK NAGTSALEVL RRATIKRSRT
     EAMTRDSSDE HCVDISSVGT PLARASIKSA KVDGVSYFRH KERLLRISIR HMVKSQVFYW
     IVLSLVALNT ACVAIVHHNQ PQWLTHLLYY AEFLFLGLFL LEMSLKMYGM GPRLYFHSSF
     NCFDFGVTVG SIFEVVWAIF RPGTSFGISV LRALRLLRIF KITKYWASLR NLVVSLMSSM
     KSIISLLFLL FLFIVVFALL GMQLFGGRFN FNDGTPSANF DTFPAAIMTV FQILTGEDWN
     EVMYNGIRSQ GGVSSGMWSA IYFIVLTLFG NYTLLNVFLA IAVDNLANAQ ELTKDEQEEE
     EAFNQKHALQ KAKEVSPMSA PNMPSIERDR RRRHHMSMWE PRSSHLRERR RRHHMSVWEQ
     RTNQLRKHMQ MSSQEDLNRE EARTKNPLNP LNPLSSLNPL NAHPSLYRRP RAIEGLALGL
     ALKKLEEERI SRGGSLKGDG GDRSSALDNQ RTPLSLGQRE PPWLARPCHG NCDPTQQEAG
     GGEAVVTFED RARHRQSQRR SRHRRVRTEG KESSSASRSR SASQERSLDE AMPTEGEKDH
     ELRGNHGAKE PTIQEERAQD LRRTNSLMVS RGSGLAGGLD EADTPLVLPH PELEVGKHVV
     LTEQEPEGSS EQALLGNVQL DMGRVISQSE PDLSCITANT DKATTESTSV TVAIPDVDPL
     VDSTVVHISN KTDGEASPLK EAEIREDEEE VEKKKQKKEK RETGKAMVPH SSMFIFSTTN
     PIRRACHYIV NLRYFEMCIL LVIAASSIAL AAEDPVLTNS ERNKVLRYFD YVFTGVFTFE
     MVIKMIDQGL ILQDGSYFRD LWNILDFVVV VGALVAFALA VTLTNKGRDI KTIKSLRVLR
     VLRPLKTIKR LPKLKAVFDC VVTSLKNVFN ILIVYKLFMF IFAVIAVQLF KGKFFYCTDS
     SKDTEKECIG NYVDHEKNKM EVKGREWKRH EFHYDNIIWA LLTLFTVSTG EGWPQVLQHS
     VDVTEEDRGP SRSNRMEMSI FYVVYFVVFP FFFVNIFVAL IIITFQEQGD KMMEECSLEK
     NERACIDFAI SAKPLTRYMP QNRHTFQYRV WHFVVSPSFE YTIMAMIALN TVVLMMKYYS
     APCTYELALK YLNIAFTMVF SLECVLKVIA FGFLNYFRDT WNIFDFITVI GSITEIILTD
     SKLVNTSGFN MSFLKLFRAA RLIKLLRQGY TIRILLWTFV QSFKALPYVC LLIAMLFFIY
     AIIGMQVFGN IKLDEESHIN RHNNFRSFFG SLMLLFRSAT GEAWQEIMLS CLGEKGCEPD
     TTAPSGQNEN ERCGTDLAYV YFVSFIFFCS FLMLNLFVAV IMDNFEYLTR DSSILGPHHL
     DEFVRVWAEY DRAACGRIHY TEMYEMLTLM SPPLGLGKRC PSKVAYKRLV LMNMPVAEDM
     TVHFTSTLMA LIRTALDIKI AKGGADRQQL DSELQKETLA IWPHLSQKML DLLVPMPKAS
     DLTVGKIYAA MMIMDYYKQS KVKKQRQQLE EQKNAPMFQR MEPSSLPQEI IANAKALPYL
     QQDPVSGLSG RSGYPSMSPL SPQDIFQLAC MDPADDGQFQ ERQSLEPEVS ELKSVQPSNH
     GIYLPSDTQE HAGSGRASSM PRLTVDPQVV TDPSSMRRSF STIRDKRSNS SWLEEFSMER
     SSENTYKSRR RSYHSSLRLS AHRLNSDSGH KSDTHRSGGR ERGRSKERKH LLSPDVSRCN
     SEERGTQADW ESPERRQSRS PSEGRSQTPN RQGTGSLSES SIPSVSDTST PRRSRRQLPP
     VPPKPRPLLS YSSLIRHAGS ISPPADGSEE GSPLTSQALE SNNACLTESS NSPHPQQSQH
     ASPQRYISEP YLALHEDSHA SDCGEEETLT FEAAVATSLG RSNTIGSAPP LRHSWQMPNG
     HYRRRRRGGP GPGMMCGAVN NLLSDTEEDD KC
//
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