ID   H2Q1L3_PANTR            Unreviewed;       903 AA.
AC   H2Q1L3;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 2.
DT   27-MAR-2024, entry version 51.
DE   SubName: Full=Inter-alpha-trypsin inhibitor heavy chain 5 {ECO:0000313|Ensembl:ENSPTRP00000003847.6};
GN   Name=ITIH5 {ECO:0000313|Ensembl:ENSPTRP00000003847.6,
GN   ECO:0000313|VGNC:VGNC:12350};
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pan.
OX   NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000003847.6, ECO:0000313|Proteomes:UP000002277};
RN   [1] {ECO:0000313|Ensembl:ENSPTRP00000003847.6, ECO:0000313|Proteomes:UP000002277}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16136131; DOI=10.1038/nature04072;
RG   Chimpanzee sequencing and analysis consortium;
RT   "Initial sequence of the chimpanzee genome and comparison with the human
RT   genome.";
RL   Nature 437:69-87(2005).
RN   [2] {ECO:0000313|Ensembl:ENSPTRP00000003847.6}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC   -!- SIMILARITY: Belongs to the ITIH family.
CC       {ECO:0000256|ARBA:ARBA00010158}.
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DR   EMBL; AACZ04030396; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; H2Q1L3; -.
DR   Ensembl; ENSPTRT00000004168.6; ENSPTRP00000003847.6; ENSPTRG00000002273.6.
DR   VGNC; VGNC:12350; ITIH5.
DR   eggNOG; ENOG502QPS2; Eukaryota.
DR   GeneTree; ENSGT00940000158317; -.
DR   HOGENOM; CLU_008101_0_1_1; -.
DR   OMA; AKKFIYT; -.
DR   TreeFam; TF328982; -.
DR   Proteomes; UP000002277; Chromosome 10.
DR   Bgee; ENSPTRG00000002273; Expressed in colon and 20 other cell types or tissues.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR   GO; GO:0030212; P:hyaluronan metabolic process; IEA:InterPro.
DR   CDD; cd01461; vWA_interalpha_trypsin_inhibitor; 1.
DR   Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR   InterPro; IPR010600; ITI_HC_C.
DR   InterPro; IPR013694; VIT.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   PANTHER; PTHR10338; INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN FAMILY MEMBER; 1.
DR   PANTHER; PTHR10338:SF62; INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN H5; 1.
DR   Pfam; PF06668; ITI_HC_C; 1.
DR   Pfam; PF08487; VIT; 1.
DR   Pfam; PF00092; VWA; 1.
DR   SMART; SM00609; VIT; 1.
DR   SMART; SM00327; VWA; 1.
DR   SUPFAM; SSF53300; vWA-like; 1.
DR   PROSITE; PS51468; VIT; 1.
DR   PROSITE; PS50234; VWFA; 1.
PE   3: Inferred from homology;
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Protease inhibitor {ECO:0000256|ARBA:ARBA00022690};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW   Serine protease inhibitor {ECO:0000256|ARBA:ARBA00022900};
KW   Signal {ECO:0000256|ARBA:ARBA00022729}.
FT   DOMAIN          1..122
FT                   /note="VIT"
FT                   /evidence="ECO:0000259|PROSITE:PS51468"
FT   DOMAIN          256..439
FT                   /note="VWFA"
FT                   /evidence="ECO:0000259|PROSITE:PS50234"
FT   REGION          76..97
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          509..532
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   903 AA;  100119 MW;  1488377BE98D5A97 CRC64;
     DSCLLNKTKP LMTEFSVKST IISRYAFTTV SCRMLNRASE DQDIEFQMQI PAAAFITNFT
     MLIGDKVYQG EITEREKKSG DRVKEKRNKT TEENGEKGTE IFRASAVIPS KDKAAFFLSY
     EELLQRRLGK YEHSISVRPQ QLSGRLSVDV NILESAGIAS LEVLPLHNSR QRGSGRGEDD
     SGPPPSTVIN QNETFANIIF KPTVVQQARI AQNGILGDFI IRYDVNREQS IGDIQVLNGY
     FVHYFAPKDL PPLPKNVVFV LDSSASMVGT KLRQTKDALF TILHDLRPQD RFSIIGFSNR
     IKVWKDHLIS VTPDSIRDGK VYIHHMSPTG GTDINGALQR AIRLLNKYVA HSGIGDRSVS
     LIVFLTDGKP TVGETHTLKI LNNTREAARG QVCIFTIGIG NDVDFRLLEK LSLENCGLTR
     RVHEEEDAGS QLIGFYDEIR TPLLSDIRID YPPSSVVQAT KTLFPNYFNG SEIIIAGKLV
     DRKLDHLHVE VTASNSKKFI ILKTDVPVGP QKAGKDVTGS PRPGGDGEGD PNHIERLWSY
     LTTKELLSSW LQSDDEPEKE RLRQRAQALA VSYRFLTPFT SMKLRGPVPR MDGLEEAHGM
     SAAMGPEPVV QSVRGAGTQP GPLLKKPYQP RIKISKTSVD GDPHFVVDFP LSRLTVCFNI
     DGQPGDILRL VSDHSDSGVT VNGELIGAPA PPNGHKKQRT YFRTITILIN KPERSYLEIT
     PSRVILDGGD RLVLPCNQSV VVGSRGLEVS VSANANVTVT IEGSIAFVIL IHLYKKPAPF
     QRHHLGFYIA NSEGLSSNCH GLLGQFLNQD ARLTEDPAGP RQNLTHPLLL QAGEGPEAVL
     TVKGHQVPVV WKQRKIYNGE EQIDCWFARN NAAKLIDGEY RDYLASHPFD TGMTLGRGMS
     REL
//