ID H2Q2I8_PANTR Unreviewed; 1871 AA.
AC H2Q2I8; A0A2J8PCT1;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=Programmed cell death 11 {ECO:0000313|EMBL:JAA44262.1, ECO:0000313|Ensembl:ENSPTRP00000005127.5};
GN Name=PDCD11 {ECO:0000313|EMBL:JAA44262.1,
GN ECO:0000313|Ensembl:ENSPTRP00000005127.5, ECO:0000313|VGNC:VGNC:5591};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000005127.5, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000005127.5, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|EMBL:JAA44262.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Skeletal muscle {ECO:0000313|EMBL:JAA44262.1};
RA Maudhoo M.D., Meehan D.T., Norgren R.B.Jr.;
RT "De novo assembly of the reference chimpanzee transcriptome from NextGen
RT mRNA sequences.";
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSPTRP00000005127.5}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000256|ARBA:ARBA00004604}.
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DR EMBL; AC190201; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; GABE01000477; JAA44262.1; -; mRNA.
DR RefSeq; XP_508013.3; XM_508013.5.
DR STRING; 9598.ENSPTRP00000005127; -.
DR PaxDb; 9598-ENSPTRP00000005127; -.
DR Ensembl; ENSPTRT00000005542.6; ENSPTRP00000005127.5; ENSPTRG00000002911.6.
DR GeneID; 450711; -.
DR CTD; 22984; -.
DR VGNC; VGNC:5591; PDCD11.
DR eggNOG; KOG1070; Eukaryota.
DR GeneTree; ENSGT00390000012228; -.
DR HOGENOM; CLU_000845_1_1_1; -.
DR OMA; GQYLRAY; -.
DR OrthoDB; 167902at2759; -.
DR TreeFam; TF105697; -.
DR Proteomes; UP000002277; Chromosome 10.
DR Bgee; ENSPTRG00000002911; Expressed in fibroblast and 20 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR GO; GO:0032040; C:small-subunit processome; IBA:GO_Central.
DR GO; GO:0051059; F:NF-kappaB binding; IEA:Ensembl.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR CDD; cd05701; S1_Rrp5_repeat_hs10; 1.
DR CDD; cd05702; S1_Rrp5_repeat_hs11_sc8; 1.
DR CDD; cd05703; S1_Rrp5_repeat_hs12_sc9; 1.
DR CDD; cd05704; S1_Rrp5_repeat_hs13; 1.
DR CDD; cd05705; S1_Rrp5_repeat_hs14; 1.
DR CDD; cd05693; S1_Rrp5_repeat_hs1_sc1; 1.
DR CDD; cd05694; S1_Rrp5_repeat_hs2_sc2; 1.
DR CDD; cd05695; S1_Rrp5_repeat_hs3; 1.
DR CDD; cd05696; S1_Rrp5_repeat_hs4; 1.
DR CDD; cd05697; S1_Rrp5_repeat_hs5; 1.
DR CDD; cd05698; S1_Rrp5_repeat_hs6_sc5; 1.
DR CDD; cd05699; S1_Rrp5_repeat_hs7; 1.
DR CDD; cd04461; S1_Rrp5_repeat_hs8_sc7; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 8.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR003107; HAT.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR045209; Rrp5.
DR InterPro; IPR048058; Rrp5_S1_rpt_hs11_sc8.
DR InterPro; IPR048059; Rrp5_S1_rpt_hs1_sc1.
DR InterPro; IPR003029; S1_domain.
DR InterPro; IPR008847; Suf.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR23270; PROGRAMMED CELL DEATH PROTEIN 11 PRE-RRNA PROCESSING PROTEIN RRP5; 1.
DR PANTHER; PTHR23270:SF10; PROTEIN RRP5 HOMOLOG; 1.
DR Pfam; PF00575; S1; 4.
DR Pfam; PF05843; Suf; 1.
DR SMART; SM00386; HAT; 6.
DR SMART; SM00316; S1; 12.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 11.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS50126; S1; 12.
PE 2: Evidence at transcript level;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW rRNA processing {ECO:0000256|ARBA:ARBA00022552}.
FT DOMAIN 83..171
FT /note="S1 motif"
FT /evidence="ECO:0000259|PROSITE:PS50126"
FT DOMAIN 187..258
FT /note="S1 motif"
FT /evidence="ECO:0000259|PROSITE:PS50126"
FT DOMAIN 281..346
FT /note="S1 motif"
FT /evidence="ECO:0000259|PROSITE:PS50126"
FT DOMAIN 365..436
FT /note="S1 motif"
FT /evidence="ECO:0000259|PROSITE:PS50126"
FT DOMAIN 453..522
FT /note="S1 motif"
FT /evidence="ECO:0000259|PROSITE:PS50126"
FT DOMAIN 542..611
FT /note="S1 motif"
FT /evidence="ECO:0000259|PROSITE:PS50126"
FT DOMAIN 636..707
FT /note="S1 motif"
FT /evidence="ECO:0000259|PROSITE:PS50126"
FT DOMAIN 729..798
FT /note="S1 motif"
FT /evidence="ECO:0000259|PROSITE:PS50126"
FT DOMAIN 1036..1109
FT /note="S1 motif"
FT /evidence="ECO:0000259|PROSITE:PS50126"
FT DOMAIN 1149..1222
FT /note="S1 motif"
FT /evidence="ECO:0000259|PROSITE:PS50126"
FT DOMAIN 1230..1298
FT /note="S1 motif"
FT /evidence="ECO:0000259|PROSITE:PS50126"
FT DOMAIN 1324..1396
FT /note="S1 motif"
FT /evidence="ECO:0000259|PROSITE:PS50126"
FT REGION 1..62
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1394..1531
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1549..1586
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10..24
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1414..1456
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1468..1526
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1557..1586
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1871 AA; 208797 MW; AC49503B2457B689 CRC64;
MANLEESFPR GGTRKIHKPE KAFQQSVEQD NLFDISTEEG STKRKKSQKG PAKTKKLKIE
KRESSKSARE KFEILSVESL CEGMRILGCV KEVNELELVI SLPNGLQGFV QVTEICDAYT
KKLNEQVTQE QPLKDLLHLP ELFSPGMLVR CVVSSLGITD RGKKSVKLSL NPKNVNRVLS
AEALKPGMLL TGTVSSLEDH GYLVDIGVDG TRAFLPLLKA QEYIRQKNKG AKLKVGQYLN
CIVEKVKGNG GVVSLSVGHS EVSTAIATEQ QSWNLNNLLP GLVVKAQVQK VTPFGLTLNF
LTFFTGVVDF MHLDPKKAGT YFSNQAVRAC ILCVHPRTRV VRLSLRPIFL QPGRPLTRLS
CQNLGAVLDD VPVQGFFKKA GATFRLKDGV LAYARLSHLS DSKNVFNPEA FKPGNTHKCR
IIDYSQMDEL ALLSLRTSII EAQYLRYHDI EPGAVVKGTV LTIKSYGMLV KVGEQMRGLV
PPMHLADILM KNPEKKYHIG DEVKCRVLLC DPEAKKLMMT LKKTLIESKL PVINCYADAK
PGLQTHGFII RVKDYGCIVK FYNNVQGLVP KHELSTEYIP DPERVFYTGQ VVKVVVLNCE
PSKERMLLSF KLSSDPEPKK EPAGHSQKKG KAINTGQLVD VKVLEKTKDG LEVAVLPHNI
RAFLPTSHLS DHVANGPLLH HWLQAGDILH RVLCLSQSEG RVLLCRKPAL VSTVEGGQDP
KNFSEIHPGM LLIGFVKSIK DYGVFIQFPS GLSGLAPKAI MSDKFVTSTS DHFVEGQTVA
AKVTNVDEEK QRMLLSLRLS DCGLGDLAIT SLLLLNQCLE ELQGVRSLMS NRDSVLIQTL
AEMTPGMFLD LVVREVLEDG SVVFSGGPVP DLVLKASRYH RAGQEVESGQ KKKVVILNVD
LLKLEVHVSL HQDLVNRKAR KLRKGSEHQA VVQHLEKSFA IASLVETGHL AAFSLTSHLN
DTFRFDSEKL QVGQGVSLTL KTTEPGVTGL LLAVEGPAAK RTMRPTRKDS ETVDEDEEVD
PALTVGTIKK HTLSIGDMVT GTVKSIKPTH VVVTLEDGII GCIHASHILD DVPEGTSPTT
KLKVGKTVTA RVIGGRDMKT FKYLPISHPR FVRTIPELSV RPSELEDGHT ALNTHSVSPV
EKIKQYQAGQ TVTCFLKKYN VVKKWLEVEI APDIRGRIPL LLTSLSFKVL KHPDKKFRVG
QALRATVVGP DSSKTFLCLS LTGPHKLEEG EVAMGRVVKV TPNEGLTVSF PFGKIGTVSI
FHMSDSYSET PLEDFVPQKV VRCYILSTAD NVLTLSLRSS RTNPETKSKV EDPEINSIQD
IKEGQLLRGY VGSIQPHGVF FRLGPSVVGL ARYSHVSQHS PSKKTLYNKH LPEGKLLTAR
VLRLNHQKNL VELSFLPGDT GKPDVLSASL EGQLTKQEER KTEAEKRDQK GEKKNQKRNE
KKNQKGQEEV EMPSKEEQQP QKPQAQKRGG QECRESGSEQ ERVSKKPKKA GLSEEDDSLV
DVYYREGKEE AEETNVLPKE KQTKPAEAPR LQLSSGFAWN VGLDSLTPAL PPLAESSDSE
EDEKPHQATI KKSKKERELE KQKAEKELSR IEEALMDPGW QPESADDFDR LVLSSPNSSI
LWLQYMAFHL QATEIEKARA VAERALKTIS FREEQEKLNV WVALLNLENM YGSQESLTKV
FERAVQYNEP LKVFLHLADI YAKSEKFQEA GELYNRMLKR FRQEKAVWIK YGAFLLRRSQ
AAASHRVLQR ALECLPSKEH VDVIAKFAQL EFQLGDAERA KAIFENTLST YPKRTDVWSV
YIDMTIKHGS QKDVRDIFER VIHLSLAPKR MKFFFKRYLD YEKQHGTEKD VQAVKAKALE
YVEAKSSVLE D
//
