ID H2Q8N4_PANTR Unreviewed; 1299 AA.
AC H2Q8N4;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 60.
DE RecName: Full=Tubulin--tyrosine ligase-like protein 5 {ECO:0000256|ARBA:ARBA00041448};
GN Name=TTLL5 {ECO:0000313|Ensembl:ENSPTRP00000011141.4,
GN ECO:0000313|VGNC:VGNC:3292};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000011141.4, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000011141.4, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000011141.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-glutamate + L-glutamyl-[protein] = ADP + gamma-L-
CC glutamyl-L-glutamyl-[protein] + H(+) + phosphate;
CC Xref=Rhea:RHEA:60144, Rhea:RHEA-COMP:10208, Rhea:RHEA-COMP:15517,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:29973, ChEBI:CHEBI:29985,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:143622,
CC ChEBI:CHEBI:456216; Evidence={ECO:0000256|ARBA:ARBA00036640};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:60145;
CC Evidence={ECO:0000256|ARBA:ARBA00036640};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
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DR EMBL; AACZ04008411; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04008412; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04008413; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04008414; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSPTRT00000012032.4; ENSPTRP00000011141.4; ENSPTRG00000006560.6.
DR VGNC; VGNC:3292; TTLL5.
DR eggNOG; KOG2157; Eukaryota.
DR GeneTree; ENSGT00940000162939; -.
DR HOGENOM; CLU_006704_1_0_1; -.
DR InParanoid; H2Q8N4; -.
DR TreeFam; TF313087; -.
DR Proteomes; UP000002277; Chromosome 14.
DR Bgee; ENSPTRG00000006560; Expressed in testis and 21 other cell types or tissues.
DR GO; GO:0005813; C:centrosome; IEA:Ensembl.
DR GO; GO:0005929; C:cilium; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0015631; F:tubulin binding; IBA:GO_Central.
DR GO; GO:0070740; F:tubulin-glutamic acid ligase activity; IBA:GO_Central.
DR GO; GO:0000226; P:microtubule cytoskeleton organization; IBA:GO_Central.
DR GO; GO:0036211; P:protein modification process; IEA:InterPro.
DR GO; GO:0060041; P:retina development in camera-type eye; IEA:Ensembl.
DR Gene3D; 3.30.470.20; ATP-grasp fold, B domain; 1.
DR InterPro; IPR004344; TTL/TTLL_fam.
DR PANTHER; PTHR12241; TUBULIN POLYGLUTAMYLASE; 1.
DR PANTHER; PTHR12241:SF145; TUBULIN POLYGLUTAMYLASE TTLL5; 1.
DR Pfam; PF03133; TTL; 1.
DR SUPFAM; SSF56059; Glutathione synthetase ATP-binding domain-like; 1.
DR PROSITE; PS51221; TTL; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002277}.
FT REGION 585..627
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 832..939
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1084..1128
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1213..1271
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 595..617
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 832..849
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 865..879
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 889..939
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1084..1126
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1250..1271
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1299 AA; 145516 MW; 80D994F62A196122 CRC64;
MPIVMARDLE ETASSSEDEE VISQEDHPCI MWTGGCRRIP VLVFHADAIL TKDNNIRVIG
ERYHLSYKIV RTDSRLVRSI LTAHGFHEVH PSSTDYNLMW TGSHLKPFLL RTLSEAQKVN
HFPRSYELTR KDRLYKNIIR MQHTHGFKAF HILPQTFLLP AEYAEFCNSY SKDRGPWIVK
PVASSRGRGV YLINNPNQIS LEENILVSRY INNPLLIDDF KFDVRLYVLV TSYDPLVIYL
YEEGLARFAT VRYDQGAKNI RNQFMHLTNY SVNKKSGDYV SCDDPEVEDY GNKWSMSAML
RYLKQEGRDT TALMAHVEDL IIKTIISAEL AIATACKTFV PHRSSCFELY GFDVLIDSTL
KPWLLEVNLS PSLACDAPLD LKIKASMISD MFTVVGFVCQ DPAQRASTRP IYPTFESSRR
NPFQKPQRCR PLSASDAEMK NLVGSAREKG PGKLVGSVLG LSMEEIKVLR RVKEENDRRG
GFIRIFPTSE TWEIYGSYLE HKTSMNYMLA TRLFQDRGNP RRSLLTGRTR MTADGAPELK
IESLNSKAKL HAALYERKLL SLEVRKRRRR SSRLRAMRPK YPVITQPAEM NVKTETESEE
EEEVSLDNED EDQEASQEES AGFLRENQAK YTPSLTALVE NTPKENSMKV REWNNKDGHC
CKLETQELEP KFNLMQILQD NGNLSKVQAR IAFSAYLQHV QIRLMKDSGS QTFSASWAAK
EDEQMELVVR FLKRASNNLQ HSLRMVLPSR RLALLERRRI LAHQLGDFII VYNKETEQMA
EKKSKKKVEE EEEDGVNTEN FQEFIRQASE AELEEVLTFY TQKNKSASVF LGTHSKSSKN
NNSYSDSGAK GDHPETIMEE VKIKPPKQQQ TTEIHSDKLS RFTTSAEKEA KLVDSNSSSG
PTATLQKIPN THLSSVTTSD LSPGPCHHSS LSQIPSAIPS MPHQPTILLN TVSASASPCL
HPGAQNIPSP AGLPRCRSGS HTIGPFSSFQ SAAHIYSQKL SRPSSAKAAG SCYLNKHHSG
IAKTQKEGED ASLYSKRYNQ SVVTAELQRL AEKQAARQYS PSSHINLLTQ QVTNLNLATG
IINRSSASTP PTLRPIISPS GPTWSTQSDP QAPENHSSSP GSRSLQTGGF AWEGEVENNV
YSKATGVVPQ HKYHPTAGSY QLHFALQQLE QQKLQSRQLL DQSRARHQAI FGSQTLPNSN
LWTMNNGAGC TISSATASGQ KPTTLPQKVV PPPSSCASLV PKPPPNHKQV LRRATSQKTS
KGSSAEGQLN GLQSSLNPAA FVPITSSTDP ISTKKNVFN
//
