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Database: UniProt
Entry: H2QCL9_PANTR
LinkDB: H2QCL9_PANTR
Original site: H2QCL9_PANTR 
ID   H2QCL9_PANTR            Unreviewed;       436 AA.
AC   H2QCL9; A0A2J8LIS9;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   24-JAN-2024, entry version 66.
DE   SubName: Full=Ring finger protein 135 {ECO:0000313|EMBL:JAA11045.1, ECO:0000313|Ensembl:ENSPTRP00000015306.3};
GN   Name=RNF135 {ECO:0000313|EMBL:JAA11045.1,
GN   ECO:0000313|Ensembl:ENSPTRP00000015306.3, ECO:0000313|VGNC:VGNC:9565};
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pan.
OX   NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000015306.3, ECO:0000313|Proteomes:UP000002277};
RN   [1] {ECO:0000313|Ensembl:ENSPTRP00000015306.3, ECO:0000313|Proteomes:UP000002277}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16136131; DOI=10.1038/nature04072;
RG   Chimpanzee sequencing and analysis consortium;
RT   "Initial sequence of the chimpanzee genome and comparison with the human
RT   genome.";
RL   Nature 437:69-87(2005).
RN   [2] {ECO:0000313|EMBL:JAA11045.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Adipose stromal {ECO:0000313|EMBL:JAA11045.1}, Skeletal muscle
RC   {ECO:0000313|EMBL:JAA35924.1}, and Skin {ECO:0000313|EMBL:JAA26482.1};
RA   Maudhoo M.D., Meehan D.T., Norgren R.B.Jr.;
RT   "De novo assembly of the reference chimpanzee transcriptome from NextGen
RT   mRNA sequences.";
RL   Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSPTRP00000015306.3}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
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DR   EMBL; AACZ04060827; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; GABC01000293; JAA11045.1; -; mRNA.
DR   EMBL; GABD01006618; JAA26482.1; -; mRNA.
DR   EMBL; GABE01008815; JAA35924.1; -; mRNA.
DR   RefSeq; XP_001174802.1; XM_001174802.4.
DR   STRING; 9598.ENSPTRP00000015306; -.
DR   PaxDb; 9598-ENSPTRP00000015306; -.
DR   Ensembl; ENSPTRT00000016536.4; ENSPTRP00000015306.3; ENSPTRG00000008967.5.
DR   GeneID; 454562; -.
DR   CTD; 84282; -.
DR   VGNC; VGNC:9565; RNF135.
DR   eggNOG; KOG2177; Eukaryota.
DR   GeneTree; ENSGT00830000128449; -.
DR   HOGENOM; CLU_032372_2_0_1; -.
DR   OMA; DCLKGLW; -.
DR   OrthoDB; 5355412at2759; -.
DR   TreeFam; TF351089; -.
DR   Proteomes; UP000002277; Chromosome 17.
DR   Bgee; ENSPTRG00000008967; Expressed in cortex of kidney and 21 other cell types or tissues.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0010494; C:cytoplasmic stress granule; IEA:Ensembl.
DR   GO; GO:1990904; C:ribonucleoprotein complex; IEA:Ensembl.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0043021; F:ribonucleoprotein complex binding; IBA:GO_Central.
DR   GO; GO:0039552; F:RIG-I binding; IEA:Ensembl.
DR   GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:Ensembl.
DR   GO; GO:0004842; F:ubiquitin-protein transferase activity; IBA:GO_Central.
DR   GO; GO:0140374; P:antiviral innate immune response; IEA:Ensembl.
DR   GO; GO:0010994; P:free ubiquitin chain polymerization; IEA:Ensembl.
DR   GO; GO:0032728; P:positive regulation of interferon-beta production; IEA:Ensembl.
DR   GO; GO:0051260; P:protein homooligomerization; IEA:Ensembl.
DR   GO; GO:0070534; P:protein K63-linked ubiquitination; IEA:Ensembl.
DR   GO; GO:0045088; P:regulation of innate immune response; IBA:GO_Central.
DR   GO; GO:0039529; P:RIG-I signaling pathway; IEA:Ensembl.
DR   CDD; cd16604; RING-HC_TRIM47-like_C-IV; 1.
DR   CDD; cd12902; SPRY_PRY_RNF135; 1.
DR   Gene3D; 2.60.120.920; -; 1.
DR   Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR043136; B30.2/SPRY_sf.
DR   InterPro; IPR003879; Butyrophylin_SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR006574; PRY.
DR   InterPro; IPR042723; RNF135_SPRY_PRY_dom.
DR   InterPro; IPR003877; SPRY_dom.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   InterPro; IPR017907; Znf_RING_CS.
DR   PANTHER; PTHR25465; B-BOX DOMAIN CONTAINING; 1.
DR   PANTHER; PTHR25465:SF5; E3 UBIQUITIN-PROTEIN LIGASE RNF135; 1.
DR   Pfam; PF00622; SPRY; 1.
DR   Pfam; PF15227; zf-C3HC4_4; 1.
DR   PRINTS; PR01407; BUTYPHLNCDUF.
DR   SMART; SM00589; PRY; 1.
DR   SMART; SM00184; RING; 1.
DR   SMART; SM00449; SPRY; 1.
DR   SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR   SUPFAM; SSF57850; RING/U-box; 1.
DR   PROSITE; PS50188; B302_SPRY; 1.
DR   PROSITE; PS00518; ZF_RING_1; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   2: Evidence at transcript level;
KW   Immunity {ECO:0000256|ARBA:ARBA00022859};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW   ProRule:PRU00175}.
FT   DOMAIN          25..67
FT                   /note="RING-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50089"
FT   DOMAIN          245..436
FT                   /note="B30.2/SPRY"
FT                   /evidence="ECO:0000259|PROSITE:PS50188"
FT   REGION          98..125
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   436 AA;  48152 MW;  C3948639B71C9A1B CRC64;
     MAGLGLGPGP GSAVPVWLAE DDLGCIICQG LLDWPATLPC GHSFCRHCLE ALWGARGARR
     WACPTCRQGA AQQPQLRKNT LLQDLADKYR RAAREIQAGS DPAHCPCPGS SPRSSAAARP
     RRRPELQRVA VEKSVTEVGQ ELTELVEHLV DIVRSLQNQR PLSESGPDNE LSILGKAFSS
     GVDLSMASPK LVTSDTAAGK IRDILHDLEE IQEKLQENVT RKEAPEAQMQ GELLEAPSSS
     SCPLPDQSHP ALRRASRFAQ WAIHPTFNLK SLSCSLEVSK DSRTVTVSHR PQPYRWSCER
     FSTSQVLCSQ ALSSGKHYWE VDTRNCSHWA VGVASWEMSR DQVLGRTMDS CCVEWKGTSQ
     LSAWHMVKET VLGSDRPGVV GIWLNLEEGK LAFYSVDNQE KLLYECTISA SSPLYPAFWL
     YGLHPGNYLI IKQVKV
//
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