ID H2QCL9_PANTR Unreviewed; 436 AA.
AC H2QCL9; A0A2J8LIS9;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 24-JAN-2024, entry version 66.
DE SubName: Full=Ring finger protein 135 {ECO:0000313|EMBL:JAA11045.1, ECO:0000313|Ensembl:ENSPTRP00000015306.3};
GN Name=RNF135 {ECO:0000313|EMBL:JAA11045.1,
GN ECO:0000313|Ensembl:ENSPTRP00000015306.3, ECO:0000313|VGNC:VGNC:9565};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000015306.3, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000015306.3, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|EMBL:JAA11045.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Adipose stromal {ECO:0000313|EMBL:JAA11045.1}, Skeletal muscle
RC {ECO:0000313|EMBL:JAA35924.1}, and Skin {ECO:0000313|EMBL:JAA26482.1};
RA Maudhoo M.D., Meehan D.T., Norgren R.B.Jr.;
RT "De novo assembly of the reference chimpanzee transcriptome from NextGen
RT mRNA sequences.";
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSPTRP00000015306.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
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DR EMBL; AACZ04060827; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; GABC01000293; JAA11045.1; -; mRNA.
DR EMBL; GABD01006618; JAA26482.1; -; mRNA.
DR EMBL; GABE01008815; JAA35924.1; -; mRNA.
DR RefSeq; XP_001174802.1; XM_001174802.4.
DR STRING; 9598.ENSPTRP00000015306; -.
DR PaxDb; 9598-ENSPTRP00000015306; -.
DR Ensembl; ENSPTRT00000016536.4; ENSPTRP00000015306.3; ENSPTRG00000008967.5.
DR GeneID; 454562; -.
DR CTD; 84282; -.
DR VGNC; VGNC:9565; RNF135.
DR eggNOG; KOG2177; Eukaryota.
DR GeneTree; ENSGT00830000128449; -.
DR HOGENOM; CLU_032372_2_0_1; -.
DR OMA; DCLKGLW; -.
DR OrthoDB; 5355412at2759; -.
DR TreeFam; TF351089; -.
DR Proteomes; UP000002277; Chromosome 17.
DR Bgee; ENSPTRG00000008967; Expressed in cortex of kidney and 21 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0010494; C:cytoplasmic stress granule; IEA:Ensembl.
DR GO; GO:1990904; C:ribonucleoprotein complex; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0043021; F:ribonucleoprotein complex binding; IBA:GO_Central.
DR GO; GO:0039552; F:RIG-I binding; IEA:Ensembl.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:Ensembl.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IBA:GO_Central.
DR GO; GO:0140374; P:antiviral innate immune response; IEA:Ensembl.
DR GO; GO:0010994; P:free ubiquitin chain polymerization; IEA:Ensembl.
DR GO; GO:0032728; P:positive regulation of interferon-beta production; IEA:Ensembl.
DR GO; GO:0051260; P:protein homooligomerization; IEA:Ensembl.
DR GO; GO:0070534; P:protein K63-linked ubiquitination; IEA:Ensembl.
DR GO; GO:0045088; P:regulation of innate immune response; IBA:GO_Central.
DR GO; GO:0039529; P:RIG-I signaling pathway; IEA:Ensembl.
DR CDD; cd16604; RING-HC_TRIM47-like_C-IV; 1.
DR CDD; cd12902; SPRY_PRY_RNF135; 1.
DR Gene3D; 2.60.120.920; -; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR003879; Butyrophylin_SPRY.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR006574; PRY.
DR InterPro; IPR042723; RNF135_SPRY_PRY_dom.
DR InterPro; IPR003877; SPRY_dom.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR25465; B-BOX DOMAIN CONTAINING; 1.
DR PANTHER; PTHR25465:SF5; E3 UBIQUITIN-PROTEIN LIGASE RNF135; 1.
DR Pfam; PF00622; SPRY; 1.
DR Pfam; PF15227; zf-C3HC4_4; 1.
DR PRINTS; PR01407; BUTYPHLNCDUF.
DR SMART; SM00589; PRY; 1.
DR SMART; SM00184; RING; 1.
DR SMART; SM00449; SPRY; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50188; B302_SPRY; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 2: Evidence at transcript level;
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 25..67
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 245..436
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT REGION 98..125
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 436 AA; 48152 MW; C3948639B71C9A1B CRC64;
MAGLGLGPGP GSAVPVWLAE DDLGCIICQG LLDWPATLPC GHSFCRHCLE ALWGARGARR
WACPTCRQGA AQQPQLRKNT LLQDLADKYR RAAREIQAGS DPAHCPCPGS SPRSSAAARP
RRRPELQRVA VEKSVTEVGQ ELTELVEHLV DIVRSLQNQR PLSESGPDNE LSILGKAFSS
GVDLSMASPK LVTSDTAAGK IRDILHDLEE IQEKLQENVT RKEAPEAQMQ GELLEAPSSS
SCPLPDQSHP ALRRASRFAQ WAIHPTFNLK SLSCSLEVSK DSRTVTVSHR PQPYRWSCER
FSTSQVLCSQ ALSSGKHYWE VDTRNCSHWA VGVASWEMSR DQVLGRTMDS CCVEWKGTSQ
LSAWHMVKET VLGSDRPGVV GIWLNLEEGK LAFYSVDNQE KLLYECTISA SSPLYPAFWL
YGLHPGNYLI IKQVKV
//