ID H2QCP6_PANTR Unreviewed; 901 AA.
AC H2QCP6; A0A2J8LJA4;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Schlafen family member 11 {ECO:0000313|EMBL:JAA09854.1, ECO:0000313|Ensembl:ENSPTRP00000015381.1};
GN Name=SLFN11 {ECO:0000313|EMBL:JAA09854.1,
GN ECO:0000313|Ensembl:ENSPTRP00000015381.1, ECO:0000313|VGNC:VGNC:9628};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000015381.1, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000015381.1, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|EMBL:JAA09854.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Adipose stromal {ECO:0000313|EMBL:JAA09854.1}, Skeletal muscle
RC {ECO:0000313|EMBL:JAA43153.1}, Skin {ECO:0000313|EMBL:JAA22622.1}, and
RC Smooth vascular {ECO:0000313|EMBL:JAA20920.1};
RA Maudhoo M.D., Meehan D.T., Norgren R.B.Jr.;
RT "De novo assembly of the reference chimpanzee transcriptome from NextGen
RT mRNA sequences.";
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSPTRP00000015381.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the Schlafen family. Subgroup III subfamily.
CC {ECO:0000256|ARBA:ARBA00010114}.
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DR EMBL; AACZ04043897; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC159904; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; GABC01001484; JAA09854.1; -; mRNA.
DR EMBL; GABF01001225; JAA20920.1; -; mRNA.
DR EMBL; GABF01001224; JAA20921.1; -; mRNA.
DR EMBL; GABD01010478; JAA22622.1; -; mRNA.
DR EMBL; GABE01001586; JAA43153.1; -; mRNA.
DR RefSeq; XP_001174320.1; XM_001174320.4.
DR RefSeq; XP_001174334.1; XM_001174334.4.
DR RefSeq; XP_009430670.1; XM_009432395.2.
DR RefSeq; XP_009430671.1; XM_009432396.2.
DR RefSeq; XP_009430674.1; XM_009432399.2.
DR STRING; 9598.ENSPTRP00000015381; -.
DR PaxDb; 9598-ENSPTRP00000015381; -.
DR Ensembl; ENSPTRT00000016617.2; ENSPTRP00000015381.1; ENSPTRG00000009017.6.
DR GeneID; 454584; -.
DR KEGG; ptr:454584; -.
DR CTD; 91607; -.
DR VGNC; VGNC:9628; SLFN11.
DR eggNOG; ENOG502QWKG; Eukaryota.
DR GeneTree; ENSGT00410000025651; -.
DR HOGENOM; CLU_007071_0_0_1; -.
DR OMA; HKLCVIP; -.
DR OrthoDB; 5398472at2759; -.
DR TreeFam; TF337168; -.
DR Proteomes; UP000002277; Chromosome 17.
DR Bgee; ENSPTRG00000009017; Expressed in lymph node and 15 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0090734; C:site of DNA damage; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:Ensembl.
DR GO; GO:0000049; F:tRNA binding; IBA:GO_Central.
DR GO; GO:0006338; P:chromatin remodeling; IEA:Ensembl.
DR GO; GO:0051607; P:defense response to virus; IBA:GO_Central.
DR GO; GO:0006974; P:DNA damage response; IEA:Ensembl.
DR GO; GO:2000134; P:negative regulation of G1/S transition of mitotic cell cycle; IEA:Ensembl.
DR GO; GO:0043111; P:replication fork arrest; IEA:Ensembl.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 3.30.950.30; Schlafen, AAA domain; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR031450; Poxin-SLFN/SLFN_N.
DR InterPro; IPR029684; Schlafen.
DR InterPro; IPR007421; Schlafen_AlbA_2_dom.
DR InterPro; IPR038461; Schlafen_AlbA_2_dom_sf.
DR InterPro; IPR018647; SLFN_3-like_DNA/RNA_helicase.
DR InterPro; IPR048729; SLFN_GTPase-like.
DR PANTHER; PTHR12155; SCHLAFEN; 1.
DR PANTHER; PTHR12155:SF45; SCHLAFEN FAMILY MEMBER 11; 1.
DR Pfam; PF17057; B3R; 1.
DR Pfam; PF09848; SLFN-g3_helicase; 1.
DR Pfam; PF04326; SLFN_AlbA_2; 1.
DR Pfam; PF21026; SLFN_GTPase-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 2: Evidence at transcript level;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277}.
FT DOMAIN 88..157
FT /note="Poxin-Schlafen/Schlafen-like N-terminal"
FT /evidence="ECO:0000259|Pfam:PF17057"
FT DOMAIN 209..322
FT /note="Schlafen AlbA-2"
FT /evidence="ECO:0000259|Pfam:PF04326"
FT DOMAIN 405..541
FT /note="Schlafen GTPase-like"
FT /evidence="ECO:0000259|Pfam:PF21026"
FT DOMAIN 595..707
FT /note="Schlafen group 3-like DNA/RNA helicase"
FT /evidence="ECO:0000259|Pfam:PF09848"
SQ SEQUENCE 901 AA; 102940 MW; 6984D712030CF015 CRC64;
MEANQCPLVV EPSYPDLVIN VGEVTLGEEN RKKLQKIQRD QEKERVMRAA CALLNSGGGV
IRMAKKVEHP VEMGLDLEQS LRELIQSSDL QAFFETKQQG RCFYIFVKSW GSGPFPEDRS
VKPRLCSLSS SLYRRSETSV RSMDSREAFC FLKTKRKPKI LEEGPFHKIH KGVYQELPNS
DPADPNSDPA DLIFQKDYLE YGEILPFPES QLVEFKQFST KHIQEYVKRT IPEYVPAFAN
TGGGYLFIGV DDKSRKVLGC AKENVDPDSL RRKIEQAIYK LPCVHFCQPQ RPITFTLKIV
DVLKRGELYG YACMIRVNPF CCAVFSEAPN SWIVEDKYVC RLTTKKWVGM MTDTDPDLLQ
LSEDFECQLS LCSGPPLSRP VYSKKGLEHK KELQQLLFSV PPGYLQYTPE SLWRDLISEH
NGLEELINKQ MQPFFRGILI FSRSWAVDLN LQEKPGVICD ALLIAQNSTP ILYTILREQD
AEGQDYCTRT AFTLKQKLVN MGGYTGKVCV RAKVLCLSPE SSAEALEAAV SPMDYPASYS
LAGTQHMEAL LQSLVIVLLG FRSLLSDQLR CEILNLLTAQ QYEIFSRSLR KNRELFVHGL
PGSGKTIMAM KIMEKIRNVF HCEAHRILYV CENQPLRNFI SDRNICRAET RKTFLRENFE
HIQHIVIDEA QNFRTEDGDW YGKAKSITRR AKGGSGILWI FLDYFQTSHL DCSGLPPLSD
QYPREELTRI VRNADPIAKY LQKEMQVIRN NPSFNIPTGC LEVLPEAEWS QGVQGTLRIK
KYLTVEQIMT CVADTCRRFF DRGYSPKDVA VLVSTAKEVE HYKYELLKAM RKKRIVQLSD
ACDMLGDHIV LDSVRRFSGL ERSIVFGIHP RTTDPAILPN ILICLASRAK QHLYIFPWGG
H
//
