ID H2QD69_PANTR Unreviewed; 359 AA.
AC H2QD69; A0A2J8J4J2;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 27-MAR-2024, entry version 74.
DE RecName: Full=Mitochondrial glutathione transporter SLC25A39 {ECO:0000256|RuleBase:RU369018};
DE AltName: Full=Solute carrier family 25 member 39 {ECO:0000256|RuleBase:RU369018};
GN Name=SLC25A39 {ECO:0000313|EMBL:JAA11175.1,
GN ECO:0000313|Ensembl:ENSPTRP00000015771.5, ECO:0000313|VGNC:VGNC:9620};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000015771.5, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000015771.5, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|EMBL:JAA11175.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Adipose stromal {ECO:0000313|EMBL:JAA11175.1}, Skeletal muscle
RC {ECO:0000313|EMBL:JAA42216.1}, Skin {ECO:0000313|EMBL:JAA27576.1}, and
RC Smooth vascular {ECO:0000313|EMBL:JAA15712.1};
RA Maudhoo M.D., Meehan D.T., Norgren R.B.Jr.;
RT "De novo assembly of the reference chimpanzee transcriptome from NextGen
RT mRNA sequences.";
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSPTRP00000015771.5}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Mitochondrial transporter required for glutathione import
CC into mitochondria. Glutathione, which plays key roles in oxidative
CC metabolism, is produced exclusively in the cytosol and is imported in
CC many organelles. Mitochondrial glutathione is required for the activity
CC and stability of proteins containing iron-sulfur clusters, as well as
CC erythropoiesis. {ECO:0000256|RuleBase:RU369018}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=glutathione(in) = glutathione(out); Xref=Rhea:RHEA:74819,
CC ChEBI:CHEBI:57925; Evidence={ECO:0000256|ARBA:ARBA00036017};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Mitochondrion
CC inner membrane {ECO:0000256|ARBA:ARBA00004448,
CC ECO:0000256|RuleBase:RU369018}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004448, ECO:0000256|RuleBase:RU369018}.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000256|ARBA:ARBA00006375, ECO:0000256|RuleBase:RU000488}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU369018}.
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DR EMBL; AACZ04050588; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; GABC01000163; JAA11175.1; -; mRNA.
DR EMBL; GABF01006433; JAA15712.1; -; mRNA.
DR EMBL; GABD01005524; JAA27576.1; -; mRNA.
DR EMBL; GABE01002523; JAA42216.1; -; mRNA.
DR RefSeq; XP_016787153.1; XM_016931664.1.
DR STRING; 9598.ENSPTRP00000075114; -.
DR PaxDb; 9598-ENSPTRP00000015771; -.
DR Ensembl; ENSPTRT00000017037.6; ENSPTRP00000015771.5; ENSPTRG00000009272.6.
DR GeneID; 739075; -.
DR CTD; 51629; -.
DR VGNC; VGNC:9620; SLC25A39.
DR eggNOG; KOG0761; Eukaryota.
DR GeneTree; ENSGT00940000156382; -.
DR HOGENOM; CLU_015166_0_0_1; -.
DR OrthoDB; 3490716at2759; -.
DR TreeFam; TF314720; -.
DR Proteomes; UP000002277; Chromosome 17.
DR Bgee; ENSPTRG00000009272; Expressed in cortex of kidney and 21 other cell types or tissues.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006783; P:heme biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:1990542; P:mitochondrial transmembrane transport; IEA:InterPro.
DR Gene3D; 1.50.40.10; Mitochondrial carrier domain; 2.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR InterPro; IPR045315; Mtm1-like.
DR PANTHER; PTHR45760; FI19922P1-RELATED; 1.
DR PANTHER; PTHR45760:SF1; MITOCHONDRIAL GLUTATHIONE TRANSPORTER SLC25A39-RELATED; 1.
DR Pfam; PF00153; Mito_carr; 4.
DR SUPFAM; SSF103506; Mitochondrial carrier; 1.
DR PROSITE; PS50920; SOLCAR; 3.
PE 2: Evidence at transcript level;
KW Heme biosynthesis {ECO:0000256|ARBA:ARBA00023133};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW ProRule:PRU00282}; Mitochondrion {ECO:0000256|RuleBase:RU369018};
KW Mitochondrion inner membrane {ECO:0000256|RuleBase:RU369018};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Repeat {ECO:0000256|RuleBase:RU369018};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW ProRule:PRU00282}; Transmembrane helix {ECO:0000256|RuleBase:RU369018};
KW Transport {ECO:0000256|RuleBase:RU000488}.
FT TRANSMEM 15..35
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369018"
FT TRANSMEM 123..142
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369018"
FT REPEAT 9..151
FT /note="Solcar"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
FT REPEAT 159..243
FT /note="Solcar"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
FT REPEAT 253..347
FT /note="Solcar"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
SQ SEQUENCE 359 AA; 39217 MW; 1B19E541D7B74454 CRC64;
MADQDPAGIS PLQQMVASGA GAVVTSLFMT PLDVVKVRLQ SQRPSMASEL MPSSRLWSLS
YTKLPFSLQS TGKCLLYCNG VLEPLYLCPN GARCATWFQD PTRFTGTMDA FVKIVRHEGT
RTLWSGLPAT LVMTVPATAI YFTAYDQLKA FLCGRALTSD LYAPMVAGAL ARLGTVTVIS
PLELMRTKLQ AQHVSYRELG ACVRTAVAQG GWRSLWLGWG PTALRDVPFS ALYWFNYELV
KSWLNGLRPK DQTSVGMSFV AGGISGTVAA VLTLPFDVVK TQRQVALGAM EAVRVNPLHV
DSTWLLLQRI RAESGTKGLF AGFLPRIIKA APSCAIMIST YEFGKSFFQR LNQDRLLGG
//
