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Database: UniProt
Entry: H2QDN9_PANTR
LinkDB: H2QDN9_PANTR
Original site: H2QDN9_PANTR 
ID   H2QDN9_PANTR            Unreviewed;      1660 AA.
AC   H2QDN9;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   30-AUG-2017, entry version 40.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=SCN4A {ECO:0000313|Ensembl:ENSPTRP00000016195};
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Pan.
OX   NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000016195, ECO:0000313|Proteomes:UP000002277};
RN   [1] {ECO:0000313|Ensembl:ENSPTRP00000016195, ECO:0000313|Proteomes:UP000002277}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16136131; DOI=10.1038/nature04072;
RG   Chimpanzee sequencing and analysis consortium;
RT   "Initial sequence of the chimpanzee genome and comparison with the
RT   human genome.";
RL   Nature 437:69-87(2005).
RN   [2] {ECO:0000313|Proteomes:UP000002277}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16136134; DOI=10.1038/nature04101;
RA   Hughes J.F., Skaletsky H., Pyntikova T., Minx P.J., Graves T.,
RA   Rozen S., Wilson R.K., Page D.C.;
RT   "Conservation of Y-linked genes during human evolution revealed by
RT   comparative sequencing in chimpanzee.";
RL   Nature 437:100-103(2005).
RN   [3] {ECO:0000313|Ensembl:ENSPTRP00000016195}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSPTRP00000016195}.
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DR   EMBL; AACZ03108567; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AACZ03108568; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AACZ03108569; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AACZ03108570; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AACZ03108571; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9598.ENSPTRP00000016195; -.
DR   PaxDb; H2QDN9; -.
DR   Ensembl; ENSPTRT00000017486; ENSPTRP00000016195; ENSPTRG00000009532.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; COG1226; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   InParanoid; H2QDN9; -.
DR   OMA; GNDTWYG; -.
DR   OrthoDB; EOG091G00FK; -.
DR   TreeFam; TF323985; -.
DR   Proteomes; UP000002277; Chromosome 17.
DR   Bgee; ENSPTRG00000009532; -.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IBA:GO_Central.
DR   GO; GO:0086010; P:membrane depolarization during action potential; IBA:GO_Central.
DR   GO; GO:0019228; P:neuronal action potential; IBA:GO_Central.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR008052; Na_channel_a4su_mammal.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   PRINTS; PR01665; NACHANNEL4.
DR   PROSITE; PS50096; IQ; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002277};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN      130    418       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      471    661       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      671    880       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN      885   1004       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1177   1432       Ion_trans. {ECO:0000259|Pfam:PF00520}.
SQ   SEQUENCE   1660 AA;  187565 MW;  FCBD8F26BC076DD5 CRC64;
     MARPSLCTLV PLGPECLRPF TRESLAAIEQ RAVEEEARLQ RNKQMEIEEP ERKPRSDLEA
     GKNLPMIYGD PPPEVIGIPL EDLDPYYSNK KTFIVLNKGK AIFRFSATPA LYLLSPFSVV
     RRGAIKVLIH ALFSMFIMIT ILTNCVFMTM SDPPPWSKNV EYTFTGIYTF ESLIKILARG
     FCVDDFTFLR DPWNWLDFSV IMMAYLTEFV DLGNISALRT FRVLRALKTI TVIPGLKTIV
     GALIQSVKKL SDVMILTVFC LSVFALVGLQ LFMGNLRQKC VRWPPLFNDT NTTWYSNDTW
     YGNDTWYGNE MWYDNDSWYA NDTWNSHASW ATNDTFDWDA YISDEGNFYF LEGSNDALLC
     GNSSDAGHCP EGYECIKTGR NPNYGYTSYD TFSWAFLALF RLMTQDYWEN LFQLTLAAGA
     KAAQALEGGE ADGDPAHGKD CNGSLDTSQG EKGAPRQSGS GDSGISDAME VFTGIFTAEM
     VLKLIAMDPY EYFQQGWNIF DSIIVTLSLV ELGLANVQGL SVLRSFRLLR VFKLAKSWPT
     LNMLIKIIGN SVGALGNLTL VLAIIVFIFA VVGMQLFGKS YKECVCKIAL DCNLPRWHMH
     DFFHSFLIVF RILCGEWIET MWDCMEVAGQ AMCLTVFLMV MVIGNLVVLN LFLALLLSSF
     SADSLAASDE DGEMNNLQIA IGRIKLGIGF AKAFLLGLLH GKILSPKDIM LSLGEADGAG
     EAGEAGETAP EDEKKEPPEE DLKKDNHILN HMGLADGPPS SLELDHLNFI NNPYLTIQVP
     IASEESDLEM PTEEETDTFS EPEDSKKPPQ PLYDGNSSVC STADYKPPEE DPEEQAEENP
     EGEQPEECFT EACVQRWPCL YVDISQGRGK KWWTLRRACF TIVEHNWFET FIVFMILLSS
     GALAFEDIYI EQRRVIRTIL EYADKVFTYI FIMEMLLKWV AYGFKVYFTN AWCWLDFLIV
     DVSIISLVAN WLGYSELGPI KSLRTLRALR PLRALSRFEG MRVNLFAGKF YYCINTTTSE
     RFDISEVNNK SECESLMHTG QVRWLNVKVN YDNVGLGYLS LLQVATFKGW MDIMYAAVDS
     REKEEQPQYE VNLYMYLYFV IFIIFGSFFT LNLFIGVIID NFNQQKKKLG GKDIFMTEEQ
     KKYYNAMKKL GSKKPQKPIP RPQNKIQGMV YDLVTKQAFD ITIMILICLN MVTMMVETDD
     QSQLKVDILY NINMIFIIIF TGECVLKMLA LRQYYFTVGW NIFDFVVVIL SIVGLALSDL
     IQKYFVSPTL FRVIRLARIG RVLRLIRGAK GIRTLLFALM MSLPALFNIG LLLFLVMFIY
     SIFGMSNFAY VKKESGIDDM FNFETFGNSI ICLFEITTSA GWDGLLNPIL NSGPPDCDPN
     LENPGTSVKG DCGNPSIGIC FFCSYIIISF LIVVNMYIAI ILENFNVATE ESSEPLGEDD
     FEMFYETWEK FDPDATQFIA YSRLSDFVDT LQEPLRIAKP NKIKLITLDL PMVPGDKIHC
     LDILFALTKE VLGDSGEMDA LKQTMEEKFM AANPSKVSYE PITTTLKRKH EEVCAIKIQR
     AYRRHLLQRS VKQASYMYRH SHDGSGDDAP EKEGLLANTM SKMYGHENGN SSSPSPEEKG
     EAGDTGPTMG LMPISPSDTA WPPAPPPGQT VRPGVKESLV
//
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