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Database: UniProt
Entry: H2QEQ1_PANTR
LinkDB: H2QEQ1_PANTR
Original site: H2QEQ1_PANTR 
ID   H2QEQ1_PANTR            Unreviewed;       508 AA.
AC   H2QEQ1; A0A2J8KWP2;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   24-JAN-2024, entry version 62.
DE   SubName: Full=Carnosine dipeptidase 1 {ECO:0000313|Ensembl:ENSPTRP00000017188.5};
GN   Name=CNDP1 {ECO:0000313|Ensembl:ENSPTRP00000017188.5,
GN   ECO:0000313|VGNC:VGNC:14787};
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pan.
OX   NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000017188.5, ECO:0000313|Proteomes:UP000002277};
RN   [1] {ECO:0000313|Ensembl:ENSPTRP00000017188.5, ECO:0000313|Proteomes:UP000002277}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16136131; DOI=10.1038/nature04072;
RG   Chimpanzee sequencing and analysis consortium;
RT   "Initial sequence of the chimpanzee genome and comparison with the human
RT   genome.";
RL   Nature 437:69-87(2005).
RN   [2] {ECO:0000313|Ensembl:ENSPTRP00000017188.5}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|PIRSR:PIRSR037242-3};
CC       Note=Binds 2 manganese ions per subunit.
CC       {ECO:0000256|PIRSR:PIRSR037242-3};
CC   -!- SIMILARITY: Belongs to the peptidase M20A family.
CC       {ECO:0000256|ARBA:ARBA00006247}.
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DR   EMBL; AACZ04062348; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_001136945.1; XM_001136945.5.
DR   AlphaFoldDB; H2QEQ1; -.
DR   STRING; 9598.ENSPTRP00000062084; -.
DR   MEROPS; M20.006; -.
DR   PaxDb; 9598-ENSPTRP00000017188; -.
DR   Ensembl; ENSPTRT00000018555.6; ENSPTRP00000017188.5; ENSPTRG00000010115.6.
DR   GeneID; 455474; -.
DR   KEGG; ptr:455474; -.
DR   CTD; 84735; -.
DR   VGNC; VGNC:14787; CNDP1.
DR   eggNOG; KOG2276; Eukaryota.
DR   GeneTree; ENSGT00940000160484; -.
DR   HOGENOM; CLU_029469_3_1_1; -.
DR   OrthoDB; 177966at2759; -.
DR   TreeFam; TF300633; -.
DR   Proteomes; UP000002277; Chromosome 18.
DR   Bgee; ENSPTRG00000010115; Expressed in liver and 10 other cell types or tissues.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0070573; F:metallodipeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd05676; M20_dipept_like_CNDP; 1.
DR   Gene3D; 3.30.70.360; -; 1.
DR   Gene3D; 3.40.630.10; Zn peptidases; 1.
DR   InterPro; IPR001261; ArgE/DapE_CS.
DR   InterPro; IPR017153; CNDP/DUG1.
DR   InterPro; IPR002933; Peptidase_M20.
DR   InterPro; IPR011650; Peptidase_M20_dimer.
DR   PANTHER; PTHR43270; BETA-ALA-HIS DIPEPTIDASE; 1.
DR   PANTHER; PTHR43270:SF1; BETA-ALA-HIS DIPEPTIDASE; 1.
DR   Pfam; PF07687; M20_dimer; 1.
DR   Pfam; PF01546; Peptidase_M20; 1.
DR   PIRSF; PIRSF037242; CNDP_dipeptidase; 1.
DR   SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
DR   PROSITE; PS00759; ARGE_DAPE_CPG2_2; 1.
PE   3: Inferred from homology;
KW   Carboxypeptidase {ECO:0000256|ARBA:ARBA00022645};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Manganese {ECO:0000256|PIRSR:PIRSR037242-3};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR037242-3};
KW   Protease {ECO:0000256|ARBA:ARBA00022645};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..27
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           28..508
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5015092671"
FT   DOMAIN          251..400
FT                   /note="Peptidase M20 dimerisation"
FT                   /evidence="ECO:0000259|Pfam:PF07687"
FT   ACT_SITE        135
FT                   /evidence="ECO:0000256|PIRSR:PIRSR037242-1"
FT   ACT_SITE        200
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR037242-1"
FT   BINDING         133
FT                   /ligand="Mn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29035"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR037242-3"
FT   BINDING         166
FT                   /ligand="Mn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29035"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR037242-3"
FT   BINDING         166
FT                   /ligand="Mn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29035"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR037242-3"
FT   BINDING         201
FT                   /ligand="Mn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29035"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR037242-3"
FT   BINDING         229
FT                   /ligand="Mn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29035"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR037242-3"
FT   BINDING         479
FT                   /ligand="Mn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29035"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR037242-3"
FT   SITE            262
FT                   /note="Important for catalytic activity"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR037242-4"
SQ   SEQUENCE   508 AA;  56909 MW;  8C6FBE91C5840ACC CRC64;
     MDPKLGRMAA SLLAVLLLLL LERGMFSSPS PPPALLEKVF RYIDLHQDEF VQTLKEWVAI
     ESDSVQPVPR FRQELFRMMA MAADMLQRLG ARVASVDMGL QQLPDGQSLP IPPIILAELG
     SDPTKGTVCF YGHLDVQPAD QGDGWLTDPY VLTEVDGKLY GRGATDNKGP VLAWINAVSA
     FRALEQDLPV NIKFIIEGME EAGSVALEEL VEKEKDRFFS GVDYIVISDN LWISQRKPAI
     TYGTRGNSYF MVEVKCRDQD FHSGTFGGIL HEPMADLVAL LGSLVDSSGH ILVPGIYDEV
     VRLTEEEINT YKAIHLDLEE YRNSSQIEKF LFDTKEEILM HLWRYPSLSI HGIEGAFDEP
     GAKTVIPGRV IGKFSIRLVP HMNVSVVEKQ VTRHLEDVFS KRNSSNKMVV SMALGLHPWI
     ANINDTQYLA AKRAIRTVFG TEPDMIRDGS TIPIAKMFQE IVHKSVVLIP LGAVDDGEHS
     QNEKINRWNY IEGTKLFAAF FLEMAQLH
//
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