ID H2QFZ5_PANTR Unreviewed; 215 AA.
AC H2QFZ5;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=FA core complex associated protein 24 {ECO:0000313|Ensembl:ENSPTRP00000018486.3};
GN Name=FAAP24 {ECO:0000313|Ensembl:ENSPTRP00000018486.3,
GN ECO:0000313|VGNC:VGNC:2554};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000018486.3, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000018486.3, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000018486.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AC183276; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_512569.3; XM_512569.6.
DR AlphaFoldDB; H2QFZ5; -.
DR PaxDb; 9598-ENSPTRP00000018486; -.
DR Ensembl; ENSPTRT00000019987.4; ENSPTRP00000018486.3; ENSPTRG00000010798.4.
DR GeneID; 455926; -.
DR CTD; 91442; -.
DR VGNC; VGNC:2554; FAAP24.
DR eggNOG; KOG2841; Eukaryota.
DR GeneTree; ENSGT00390000009456; -.
DR HOGENOM; CLU_111628_0_0_1; -.
DR InParanoid; H2QFZ5; -.
DR OMA; GPVHVPF; -.
DR OrthoDB; 2906428at2759; -.
DR TreeFam; TF333015; -.
DR Proteomes; UP000002277; Chromosome 19.
DR Bgee; ENSPTRG00000010798; Expressed in fibroblast and 9 other cell types or tissues.
DR GO; GO:0000785; C:chromatin; IEA:Ensembl.
DR GO; GO:0071821; C:FANCM-MHF complex; IEA:Ensembl.
DR GO; GO:0043240; C:Fanconi anaemia nuclear complex; IBA:GO_Central.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0003682; F:chromatin binding; IBA:GO_Central.
DR GO; GO:0036297; P:interstrand cross-link repair; IEA:Ensembl.
DR CDD; cd20076; XPF_nuclease_FAAP24; 1.
DR Gene3D; 3.40.50.10130; -; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR InterPro; IPR041663; DisA/LigA_HHH.
DR InterPro; IPR026985; FAAP24.
DR InterPro; IPR040646; PND.
DR InterPro; IPR010994; RuvA_2-like.
DR PANTHER; PTHR31786; FANCONI ANEMIA CORE COMPLEX-ASSOCIATED PROTEIN 24; 1.
DR PANTHER; PTHR31786:SF2; FANCONI ANEMIA CORE COMPLEX-ASSOCIATED PROTEIN 24; 1.
DR Pfam; PF12826; HHH_2; 1.
DR Pfam; PF17949; PND; 1.
DR SUPFAM; SSF47781; RuvA domain 2-like; 1.
PE 4: Predicted;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277}.
FT DOMAIN 12..134
FT /note="Fanconi anemia core complex-associated protein 24
FT pseudonuclease"
FT /evidence="ECO:0000259|Pfam:PF17949"
FT DOMAIN 166..214
FT /note="DisA/LigA helix-hairpin-helix motif"
FT /evidence="ECO:0000259|Pfam:PF12826"
SQ SEQUENCE 215 AA; 24066 MW; 172F7271967D2D87 CRC64;
MEKNPPDDTG PVHVPLGHIV ANEKWRRSQL VQEMQGRIKL IFEDGLTPDF YLSNRCCILY
VTEADLVAGN GYRKRLVRVR NSNNLKGIVV VEKTRMSEQY FPALQKFTVL DLGMVLLPVA
SQMEASCLII QLVQEQTKEP SKNPLLGKKR ALLLSEPSLL RTVQQIPGVG KVKAPLLLQK
FPSIQQLSNA SIGELEQVVG QAVAQQIHAF FTQPR
//
