ID H2QGW6_PANTR Unreviewed; 490 AA.
AC H2QGW6; A0A2J8J0Y0;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=Polynucleotide kinase 3'-phosphatase {ECO:0000313|Ensembl:ENSPTRP00000019441.5};
GN Name=PNKP {ECO:0000313|Ensembl:ENSPTRP00000019441.5,
GN ECO:0000313|VGNC:VGNC:2440};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000019441.5, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000019441.5, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000019441.5}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AACZ04055865; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H2QGW6; -.
DR Ensembl; ENSPTRT00000021054.5; ENSPTRP00000019441.5; ENSPTRG00000011323.5.
DR VGNC; VGNC:2440; PNKP.
DR eggNOG; KOG2134; Eukaryota.
DR GeneTree; ENSGT00940000159302; -.
DR HOGENOM; CLU_014938_1_1_1; -.
DR TreeFam; TF313738; -.
DR Proteomes; UP000002277; Chromosome 19.
DR Bgee; ENSPTRG00000011323; Expressed in lymph node and 20 other cell types or tissues.
DR GO; GO:0046404; F:ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity; IEA:InterPro.
DR GO; GO:0046403; F:polynucleotide 3'-phosphatase activity; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR CDD; cd22736; FHA_PNKP; 1.
DR CDD; cd01625; HAD_PNP; 1.
DR Gene3D; 2.60.200.20; -; 1.
DR Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR041388; FHA_2.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR006549; HAD-SF_hydro_IIIA.
DR InterPro; IPR023214; HAD_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR013954; PNK3P.
DR InterPro; IPR006550; PNKP.
DR InterPro; IPR006551; Polynucleotide_phosphatase.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR NCBIfam; TIGR01664; DNA-3'-Pase; 1.
DR NCBIfam; TIGR01662; HAD-SF-IIIA; 1.
DR NCBIfam; TIGR01663; PNK-3'Pase; 1.
DR PANTHER; PTHR12083; BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE/KINASE; 1.
DR PANTHER; PTHR12083:SF9; BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE_KINASE; 1.
DR Pfam; PF13671; AAA_33; 1.
DR Pfam; PF17913; FHA_2; 1.
DR Pfam; PF08645; PNK3P; 1.
DR SUPFAM; SSF56784; HAD-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF49879; SMAD/FHA domain; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277}.
FT DOMAIN 11..80
FT /note="PNK FHA"
FT /evidence="ECO:0000259|Pfam:PF17913"
FT REGION 109..143
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 127..143
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 490 AA; 53594 MW; 5442534BCCC06EEE CRC64;
MGEVEAPGRL WLESPPGGAP PIFLPSDGQA LVLGRGPLTQ VTDRKCSRTQ VELVADPETR
TVAVKQLGVN PSTTGTQELK PGLEGSLGVG DTLYLVNGLH PLTLRWEETR TPESQPDTPP
GTPLVSQDEK RDAELPKKRM RKSNPGWENL EKLLVFTAAG VKPQGKVAGF DLDGTLITTR
SGKVFPTGPS DWRILYPEIP RKLRELEAEG YKLVIFTNQM SIGRGKLPAE EFKAKVEAVV
EKLGVPFQVL VATHAGLYRK PVTGMWDHLQ EQANDGAPIS IGDSIFVGDA AGRPANWAPG
RKKKDFSCAD RLRTVSRSGP LCLPESRALL SASPEVVVAV GFPGAGKSTF LKKHLVSAGY
VHVNRDTLGS WQRCVTTCET ALKQGKRVAI DNTNPDAASR ARYVQCARAA GVPCRCFLFT
ATLEQARHNN RFREMTDSSH IPVSDMVMYG YRKQFEAPTP AEGFSAILEI PFRLWVEPRL
GRLYCQFSEG
//
