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Database: UniProt
Entry: H2QIX3_PANTR
LinkDB: H2QIX3_PANTR
Original site: H2QIX3_PANTR 
ID   H2QIX3_PANTR            Unreviewed;      1977 AA.
AC   H2QIX3;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   07-JUN-2017, entry version 43.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=SCN9A {ECO:0000313|Ensembl:ENSPTRP00000021521};
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Pan.
OX   NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000021521, ECO:0000313|Proteomes:UP000002277};
RN   [1] {ECO:0000313|Ensembl:ENSPTRP00000021521, ECO:0000313|Proteomes:UP000002277}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16136131; DOI=10.1038/nature04072;
RG   Chimpanzee sequencing and analysis consortium;
RT   "Initial sequence of the chimpanzee genome and comparison with the
RT   human genome.";
RL   Nature 437:69-87(2005).
RN   [2] {ECO:0000313|Proteomes:UP000002277}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16136134; DOI=10.1038/nature04101;
RA   Hughes J.F., Skaletsky H., Pyntikova T., Minx P.J., Graves T.,
RA   Rozen S., Wilson R.K., Page D.C.;
RT   "Conservation of Y-linked genes during human evolution revealed by
RT   comparative sequencing in chimpanzee.";
RL   Nature 437:100-103(2005).
RN   [3] {ECO:0000313|Ensembl:ENSPTRP00000021521}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSPTRP00000021521}.
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DR   EMBL; AACZ03017792; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AACZ03017793; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AACZ03017794; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AACZ03017795; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AACZ03017796; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AACZ03017797; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AACZ03017798; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AACZ03017799; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AACZ03017800; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AACZ03017801; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9598.ENSPTRP00000021521; -.
DR   PaxDb; H2QIX3; -.
DR   Ensembl; ENSPTRT00000023338; ENSPTRP00000021521; ENSPTRG00000012597.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   InParanoid; H2QIX3; -.
DR   OMA; RQKCPPW; -.
DR   OrthoDB; EOG091G00FK; -.
DR   TreeFam; TF323985; -.
DR   Proteomes; UP000002277; Chromosome 2B.
DR   Bgee; ENSPTRG00000012597; -.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IBA:GO_Central.
DR   GO; GO:0048266; P:behavioral response to pain; IEA:Ensembl.
DR   GO; GO:0006954; P:inflammatory response; IEA:Ensembl.
DR   GO; GO:0086010; P:membrane depolarization during action potential; IBA:GO_Central.
DR   GO; GO:0019228; P:neuronal action potential; IBA:GO_Central.
DR   GO; GO:0009791; P:post-embryonic development; IEA:Ensembl.
DR   GO; GO:0009636; P:response to toxic substance; IEA:Ensembl.
DR   GO; GO:0019233; P:sensory perception of pain; IEA:Ensembl.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR024583; Na_trans_cytopl.
DR   InterPro; IPR028803; SCN9A.
DR   PANTHER; PTHR10037:SF235; PTHR10037:SF235; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   Pfam; PF11933; Na_trans_cytopl; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   SMART; SM00015; IQ; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002277};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    122    145       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    190    209       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    221    242       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    248    268       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    378    405       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    726    752       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    764    782       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    802    823       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    844    872       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    934    957       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1182   1200       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1221   1237       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1313   1333       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1382   1403       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1423   1446       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1505   1523       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1535   1553       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1565   1585       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1622   1650       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1726   1749       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN      125    411       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      484    683       Na_trans_cytopl. {ECO:0000259|Pfam:
FT                                PF11933}.
FT   DOMAIN      734    962       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      971   1176       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN     1180   1455       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1504   1759       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED      402    447       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1977 AA;  225213 MW;  4D32A907C87F341C CRC64;
     MAMLPPPGPQ SFVHFTKQSL ALIEQRIAER KSKEPKEEKK DDDEEAPKPS SDLEAGKQLP
     FIYGDIPPGM VSEPLEDLDP YYADKKTFIV LNKGKTIFRF NATPALYMLS PFSPLRRISI
     KILVHSLFSM LIMCTILTNC IFMTMNNPPD WTKNVEYTFT GIYTFESLVK ILARGFCVGE
     FTFLRDPWNW LDFVVIVFAY LTEFVNLGNV SALRTFRVLR ALKTISVIPG LKTIVGALIQ
     SVKKLSDVMI LTVFCLSVFA LIGLQLFMGN LKHKCFRNSL ENNETLESIM NTLESEEDFR
     KYFYYLEGSK DALLCGFSTD SGQCPEGYTC VKIGRNPDYG YTSFDTFSWA FLALFRLMTQ
     DYWENLYQQT LRAAGKTYMI FFVVVIFLGS FYLINLILAV VAMAYEEQNQ ANIEEAKQKE
     LEFQQMLDRL KKEQEEAEAI AAAAAEYTSI RRSRIMGLSE SSSETSKLSS KSAKERRNRR
     KKKNQKKLSS GEEKGDAEKL SKSESEDSIR RKSFHLGVEG HRRAHEKRLS TPNQSPLSIR
     GSLFSARRSS RTSLFSFKGR GRDIGSETEF ADDEHSIFGD NESRRGSLFV PHRPQERRSS
     NISQASRSPP MLPVNGKMHS AVDCNGVVSL VDGRSALMLP NGQLLPEGTT NQIHKKRRCS
     SYLLSEDMLN DPNLRQRAMS RASILTNTVE ELEESRQKCP PWWYRFAHKF LIWNCSPYWI
     KFKKCIYFIV MDPFVDLAIT ICIVLNTLFM AMEHHPMTEE FKNVLAIGNL VFTGIFAAEM
     VLKLIAMDPY EYFQVGWNIF DSLIVTLSLV ELFLADVEGL SVLRSFRLLR VFKLAKSWPT
     LNMLIKIIGN SVGALGNLTL VLAIIVFIFA VVGMQLFGKS YKECVCKIND DCTLPRWHMN
     DFFHSFLIVF RVLCGEWIET MWDCMEVAGQ AMCLIVYMMV MVIGNLVVLN LFLALLLSSF
     SSDNLTAIEE DPDANNLQIA VTRIKKGINY VKQILREFIL KAFSKKPKIS REIRQAEDLN
     TKKENYISNH TLAEMSKGHN FLKEKDKISG FGSSMDKHLM EDSDGQSFIH NPSLTVTVPI
     APGESDLENM NAEELSSDSD SEYSKVRLNQ SSSSECSTVD NPLPGEGEEA EAEPMNSDEP
     EACFTDGCVR RFSCCQVNIE SGKGKIWWNI RKTCYKIVEH SWFESFIVLM ILLSSGALAF
     EDIYIERKKT IKIILEYADK IFTYIFILEM LLKWIAYGYK TYFTNAWCWL DFLIVDVSLV
     TLVANTLGYS DLGPIKSLRT LRALRPLRAL SRFEGMRVVV NALIGAIPSI MNVLLVCLIF
     WLIFSIMGVN LFAGKFYECI NTTDGSRFPA SQVPNRSECF ALMNVSQNVR WKNLKVNFDN
     VGLGYLSLLQ VATFKGWTII MYAAVDSVNV DKQPKYEYSL YMYIYFVVFI IFGSFFTLNL
     FIGVIIDNFN QQKKKLGGQD IFMTEEQKKY YNAMKKLGSK KPQKPIPRPG NKIQGCIFDL
     VTNQAFDISI MVLICLNMVT MMVEKEGQSQ HMTEVLYWIN VVFIILFTGE CVLKLISLRH
     YYFTVGWNIF DFVVVIISIV GMFLADLIET YFVSPTLFRV IRLARIGRIL RLVKGAKGIR
     TLLFALMMSL PALFNIGLLL FLVMFIYAIF GMSNFAYVKK EDGINDMFNF ETFGNSMICL
     FQITTSAGWD GLLAPILNSK PPDCDPKKVH PGSSVEGDCG NPSVGIFYFV SYIIISFLVV
     VNMYIAVILE NFSVATEEST EPLSEDDFEM FYEVWEKFDP DATQFIEFSK LSDFAAALDP
     PLLIAKPNKV QLIAMDLPMV SGDRIHCLDI LFAFTKRVLG ESGEMDSLRS QMEERFMSAN
     PSKVSYEPIT TTLKRKQEDV SATVIQRAYR RYRLRQNVKN ISSIYIKDGD RDDDLLNKKD
     MAFDNVNENS SPEKTDATSS TTSPPSYDSV TKPDKEKYEQ DRTEKEDKGK DSKESKK
//
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