ID H2QL41_PANTR Unreviewed; 913 AA.
AC H2QL41;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 51.
DE SubName: Full=PWP2 small subunit processome component {ECO:0000313|Ensembl:ENSPTRP00000024042.5};
GN Name=PWP2 {ECO:0000313|Ensembl:ENSPTRP00000024042.5};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000024042.5, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000024042.5, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000024042.5, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136134; DOI=10.1038/nature04101;
RA Hughes J.F., Skaletsky H., Pyntikova T., Minx P.J., Graves T., Rozen S.,
RA Wilson R.K., Page D.C.;
RT "Conservation of Y-linked genes during human evolution revealed by
RT comparative sequencing in chimpanzee.";
RL Nature 437:100-103(2005).
RN [3] {ECO:0000313|Ensembl:ENSPTRP00000024042.5}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000256|ARBA:ARBA00004604}.
CC -!- SIMILARITY: Belongs to the WD repeat PWP2 family.
CC {ECO:0000256|ARBA:ARBA00010226}.
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DR EMBL; AACZ04064363; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H2QL41; -.
DR Ensembl; ENSPTRT00000026063.5; ENSPTRP00000024042.5; ENSPTRG00000013969.5.
DR eggNOG; KOG0291; Eukaryota.
DR GeneTree; ENSGT00550000074981; -.
DR HOGENOM; CLU_072952_0_1_1; -.
DR TreeFam; TF329408; -.
DR Proteomes; UP000002277; Chromosome 21.
DR Bgee; ENSPTRG00000013969; Expressed in prefrontal cortex and 21 other cell types or tissues.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0042254; P:ribosome biogenesis; IEA:UniProt.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 3.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR027145; PWP2.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR InterPro; IPR007148; SSU_processome_Utp12.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR19858:SF0; PERIODIC TRYPTOPHAN PROTEIN 2 HOMOLOG-RELATED; 1.
DR PANTHER; PTHR19858; WD40 REPEAT PROTEIN; 1.
DR Pfam; PF04003; Utp12; 1.
DR Pfam; PF00400; WD40; 3.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 12.
DR SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 3.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT REPEAT 363..395
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 405..446
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 491..524
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 764..868
FT /note="Small-subunit processome Utp12"
FT /evidence="ECO:0000259|Pfam:PF04003"
FT REGION 238..268
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 876..913
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 252..268
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 913 AA; 101716 MW; 63A26C9E7BD37799 CRC64;
ILFSSQFSNL LGTVYRRGNL NFTCDGNSVI SPVGNRVTVF DLKNNKSDTL PLATRYNVKC
VGLSPDGRLA IIVDEGGDAL LVSLVCRSVL HHFHFKGSVH SVSFSPDGRK FVVTKGNIAQ
MYHAPGKKRE FNAFVLDKTY FGPYDETTCI DWTDDSRCFV VGSKDMSTWV FGAERWDNLI
YYALGGHKDA IVACFFESNS LDLYSLSQDG VLCMWQCDTP PEGLRLKPPA GWKADLLQRE
EEEEEEEDQE GDRETTIRGK ATPAEEEKTG KVKYSRLAKY FFNKEGDFNN LTAAAFHKKS
HLLVTGFASG IFHLHELPEF NLIHSLSLTW GGPEPGTPAS PVCTGLGQLL VWEWQSESYV
LKQQGHFNSM VALAYSPDGQ YIVTGGDDGK VKVWNTLSGF CFVTFTEHSS GVTGVTFTAT
GYVVVTSSMD GTVRAFDLHR YRNFRTFTSP RPTQFSCVAV DASGEIVSAG AQDSFEIFVW
SMQTGRLLDV LSGHEGPISG LCFNPMKSIL ASASWDKTVR LWDMFDSWRT KETLALTSDA
LAVTFRPDGA ELAVATLNSQ ITFWDPENAV QMGSIEGRHD LKTGRKELDK ITAKHAAKGK
AFTALCYSAD GHSILAGGMS KFVCIYHVRE QILMKRFEIS CNLSLDAMEE FLNRRKMTEF
GNLALIDQDA GQEDGVAIPL PGVRKGDMSS RHFKPEIRVT SLRFSPTGRC WAATTTEGLL
IYSLDTRVLF DPFELDTSVT PGRVREALRQ QDFTRAILMA LRLNESKLVQ EALEAVPRGE
IEVVTSSLPE LYVEKVLEFL ASSFEVSRHL EFYLLWTHKL LMLHGQKLKS RAGTLLPVIQ
FLQKSIQRHL DDLSKLCSWN HYNMQYALAV SKQRGTKRSL DPLGSEEEAE ASEDDSLHLL
GGGGRDSEEE MLA
//
