ID H2QP88_PANTR Unreviewed; 691 AA.
AC H2QP88; A0A2J8NWE4;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE RecName: Full=F-box/LRR-repeat protein 5 {ECO:0000256|ARBA:ARBA00020540};
DE AltName: Full=F-box and leucine-rich repeat protein 5 {ECO:0000256|ARBA:ARBA00030695};
GN Name=FBXL5 {ECO:0000313|EMBL:JAA18911.1,
GN ECO:0000313|Ensembl:ENSPTRP00000027433.3, ECO:0000313|VGNC:VGNC:2990};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000027433.3, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000027433.3, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|EMBL:JAA18911.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Skeletal muscle {ECO:0000313|EMBL:JAA35878.1}, Skin
RC {ECO:0000313|EMBL:JAA24785.1}, and Smooth vascular
RC {ECO:0000313|EMBL:JAA18911.1};
RA Maudhoo M.D., Meehan D.T., Norgren R.B.Jr.;
RT "De novo assembly of the reference chimpanzee transcriptome from NextGen
RT mRNA sequences.";
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSPTRP00000027433.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:190135;
CC Evidence={ECO:0000256|ARBA:ARBA00034078};
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, perinuclear region
CC {ECO:0000256|ARBA:ARBA00004556}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; AACZ04033673; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; GABF01003234; JAA18911.1; -; mRNA.
DR EMBL; GABD01008315; JAA24785.1; -; mRNA.
DR EMBL; GABE01008861; JAA35878.1; -; mRNA.
DR RefSeq; XP_517113.3; XM_517113.5.
DR STRING; 9598.ENSPTRP00000027433; -.
DR PaxDb; 9598-ENSPTRP00000027433; -.
DR Ensembl; ENSPTRT00000029732.4; ENSPTRP00000027433.3; ENSPTRG00000015927.5.
DR GeneID; 461125; -.
DR CTD; 26234; -.
DR VGNC; VGNC:2990; FBXL5.
DR eggNOG; ENOG502QS5I; Eukaryota.
DR GeneTree; ENSGT00390000006172; -.
DR HOGENOM; CLU_017503_0_0_1; -.
DR OMA; GEMFCGH; -.
DR OrthoDB; 2913997at2759; -.
DR TreeFam; TF331105; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000002277; Chromosome 4.
DR Bgee; ENSPTRG00000015927; Expressed in bone marrow and 21 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0019005; C:SCF ubiquitin ligase complex; IBA:GO_Central.
DR GO; GO:0005506; F:iron ion binding; IEA:Ensembl.
DR GO; GO:0051536; F:iron-sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0006879; P:intracellular iron ion homeostasis; IEA:Ensembl.
DR GO; GO:0060586; P:multicellular organismal-level iron ion homeostasis; IEA:Ensembl.
DR GO; GO:0045732; P:positive regulation of protein catabolic process; IEA:Ensembl.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR GO; GO:0031146; P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR CDD; cd22118; F-box_FBXL5; 1.
DR CDD; cd12109; Hr_FBXL5; 1.
DR Gene3D; 1.20.1280.50; -; 1.
DR Gene3D; 1.20.120.520; nmb1532 protein domain like; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR036047; F-box-like_dom_sf.
DR InterPro; IPR001810; F-box_dom.
DR InterPro; IPR012312; Hemerythrin-like.
DR InterPro; IPR045808; Hr_FBXL5.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR006553; Leu-rich_rpt_Cys-con_subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR PANTHER; PTHR13318:SF19; F-BOX_LRR-REPEAT PROTEIN 5; 1.
DR PANTHER; PTHR13318; UNCHARACTERIZED; 1.
DR Pfam; PF12937; F-box-like; 1.
DR Pfam; PF01814; Hemerythrin; 1.
DR Pfam; PF13516; LRR_6; 3.
DR SMART; SM00256; FBOX; 1.
DR SMART; SM00367; LRR_CC; 4.
DR SUPFAM; SSF81383; F-box domain; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR PROSITE; PS50181; FBOX; 1.
PE 2: Evidence at transcript level;
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00023014};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 202..248
FT /note="F-box"
FT /evidence="ECO:0000259|PROSITE:PS50181"
SQ SEQUENCE 691 AA; 78599 MW; 2B04C85B09FC12DB CRC64;
MAPFPEEVDV FTAPHWRMKQ LVGLYCDKLS KTNFSNNNDF RALLQSLYAT FKEFKMHEQI
ENEYIIGLLQ QRSQTIYNVH SDNKLSEMLS LFEKGLKNVK NEYEQLNYAK QLKERLEAFT
RDFLPHMKEE EEVFQPMLME YFTYEELKDI KKKVIAQHCS QKDTAELLRG LSLWNHAEER
QKFFKYSVDE KSDKEAEVSE HSTGITHLPP EVMLSIFSYL NPQELCRCSQ VSMKWSQLTK
TGSLWKHLYP VHWARGDWYS GPATELDTEP DEEWVKNRKD ESRAFHEWDE DADIDESEES
AEESIAISIA QMEKRLLHGL IHNVLPYVGT SVKTLVLAYS SAVSSKMVRQ ILELCPNLEH
LDLTQTDISD SAFDSWSWLG CCQSLRHLDL SGCEKITDVA LEKISRALGI LTSHQSGFLK
TSTSKITSTT WKNKDITMQS TKQYACLHDL TNKGIGEEID NEHPWTKPVS SENFTSPYVW
MLDAEDLADI EDTVEWRHRN VESLCVMETA SNFSCSTSGC FSKDIVGLRT SVCWQQHCAS
PAFAYCGHSF CCTGTALRTM SSLPESSAMC RKAARTRLPR GKDLIYFGSE KSDQETGRVL
LFLSLSGCYQ ITDHGLRVLT LGGGLPYLEH LNLSGCLTIT GAGLQDLVSA CPSLNDEYFY
YCDNINGPHA DTASGCQNLQ CGFRACCRSG E
//
