ID H2QPE1_PANTR Unreviewed; 473 AA.
AC H2QPE1; A0A2J8PGI6;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=Potassium channel tetramerization domain containing 8 {ECO:0000313|Ensembl:ENSPTRP00000027567.4};
GN Name=KCTD8 {ECO:0000313|Ensembl:ENSPTRP00000027567.4,
GN ECO:0000313|VGNC:VGNC:13099};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000027567.4, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000027567.4, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000027567.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AACZ04033799; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04033800; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04033801; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04033802; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_517173.1; XM_517173.5.
DR AlphaFoldDB; H2QPE1; -.
DR SMR; H2QPE1; -.
DR STRING; 9598.ENSPTRP00000027567; -.
DR PaxDb; 9598-ENSPTRP00000027567; -.
DR Ensembl; ENSPTRT00000029873.4; ENSPTRP00000027567.4; ENSPTRG00000016020.4.
DR GeneID; 461195; -.
DR KEGG; ptr:461195; -.
DR CTD; 386617; -.
DR VGNC; VGNC:13099; KCTD8.
DR eggNOG; KOG2723; Eukaryota.
DR GeneTree; ENSGT00940000161041; -.
DR HOGENOM; CLU_057051_0_1_1; -.
DR InParanoid; H2QPE1; -.
DR OMA; EYIFYRP; -.
DR OrthoDB; 2912088at2759; -.
DR TreeFam; TF315332; -.
DR Proteomes; UP000002277; Chromosome 4.
DR Bgee; ENSPTRG00000016020; Expressed in cerebellar cortex and 11 other cell types or tissues.
DR GO; GO:0043235; C:receptor complex; IBA:GO_Central.
DR GO; GO:0051260; P:protein homooligomerization; IEA:InterPro.
DR GO; GO:0008277; P:regulation of G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR CDD; cd18396; BTB_POZ_KCTD8; 1.
DR CDD; cd22218; H1_KCTD8; 1.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR InterPro; IPR003131; T1-type_BTB.
DR PANTHER; PTHR14499:SF68; BTB_POZ DOMAIN-CONTAINING PROTEIN KCTD8; 1.
DR PANTHER; PTHR14499; POTASSIUM CHANNEL TETRAMERIZATION DOMAIN-CONTAINING; 1.
DR Pfam; PF02214; BTB_2; 1.
DR SMART; SM00225; BTB; 1.
DR SUPFAM; SSF54695; POZ domain; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002277}.
FT DOMAIN 44..154
FT /note="BTB"
FT /evidence="ECO:0000259|SMART:SM00225"
FT REGION 1..36
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 326..409
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10..29
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 327..345
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 346..392
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 473 AA; 52440 MW; D5AA3F75716D3715 CRC64;
MALKDTGSGG STILPISEMV SSSSSPGASA AAAPGPCAPS PFPEVVELNV GGQVYVTKHS
TLLSVPDSTL ASMFSPSSPR GGARRRGELP RDSRARFFID RDGFLFRYVL DYLRDKQLAL
PEHFPEKERL LREAEYFQLT DLVKLLSPKV TKQNSLNDEG CQSDLEDNVS QGSSDALLLR
GAAAAVPSGP GAHGGGGGGG AQDKRSGFLT LGYRGSYTTV RDNQADAKFR RVARIMVCGR
IALAKEVFGD TLNESRDPDR QPEKYTSRFY LKFTYLEQAF DRLSEAGFHM VACNSSGTAA
FVNQYRDDKI WSSYTEYIFF RPPQKIVSPK QEHEDRKHDK VTDKGSESGT SCNELSTSSC
DSHSEASTPQ DNPSSAQQAT AHQPNTLTLD RPSKKAPVQW IPPPDKRRNS ELFQTLISKS
RETNLSKKKV CEKLSVEEEM KKCIQDFKKI HIPDYFPERK RQWQSELLQK YGL
//
