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Database: UniProt
Entry: H2QQV0_PANTR
LinkDB: H2QQV0_PANTR
Original site: H2QQV0_PANTR 
ID   H2QQV0_PANTR            Unreviewed;       603 AA.
AC   H2QQV0;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   25-OCT-2017, entry version 40.
DE   SubName: Full=Hyperpolarization activated cyclic nucleotide gated potassium channel 1 {ECO:0000313|Ensembl:ENSPTRP00000028879};
GN   Name=HCN1 {ECO:0000313|Ensembl:ENSPTRP00000028879};
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Pan.
OX   NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000028879, ECO:0000313|Proteomes:UP000002277};
RN   [1] {ECO:0000313|Ensembl:ENSPTRP00000028879, ECO:0000313|Proteomes:UP000002277}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16136131; DOI=10.1038/nature04072;
RG   Chimpanzee sequencing and analysis consortium;
RT   "Initial sequence of the chimpanzee genome and comparison with the
RT   human genome.";
RL   Nature 437:69-87(2005).
RN   [2] {ECO:0000313|Proteomes:UP000002277}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16136134; DOI=10.1038/nature04101;
RA   Hughes J.F., Skaletsky H., Pyntikova T., Minx P.J., Graves T.,
RA   Rozen S., Wilson R.K., Page D.C.;
RT   "Conservation of Y-linked genes during human evolution revealed by
RT   comparative sequencing in chimpanzee.";
RL   Nature 437:100-103(2005).
RN   [3] {ECO:0000313|Ensembl:ENSPTRP00000028879}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSPTRP00000028879}.
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DR   EMBL; AACZ03043554; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AACZ03043555; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AACZ03043556; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AACZ03043557; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AACZ03043558; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AACZ03043559; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AACZ03043560; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AACZ03043561; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AACZ03043562; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AACZ03043563; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9598.ENSPTRP00000028879; -.
DR   PaxDb; H2QQV0; -.
DR   Ensembl; ENSPTRT00000031270; ENSPTRP00000028879; ENSPTRG00000016855.
DR   eggNOG; KOG0498; Eukaryota.
DR   eggNOG; ENOG410XPSE; LUCA.
DR   GeneTree; ENSGT00900000140801; -.
DR   InParanoid; H2QQV0; -.
DR   OMA; HREEDMG; -.
DR   OrthoDB; EOG091G0JQU; -.
DR   TreeFam; TF318250; -.
DR   Proteomes; UP000002277; Chromosome 5.
DR   Bgee; ENSPTRG00000016855; -.
DR   GO; GO:0098855; C:HCN channel complex; IEA:Ensembl.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0030552; F:cAMP binding; IEA:Ensembl.
DR   GO; GO:0005249; F:voltage-gated potassium channel activity; IBA:GO_Central.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:Ensembl.
DR   GO; GO:0071320; P:cellular response to cAMP; IEA:Ensembl.
DR   GO; GO:0051289; P:protein homotetramerization; IEA:Ensembl.
DR   GO; GO:0042391; P:regulation of membrane potential; IBA:GO_Central.
DR   CDD; cd00038; CAP_ED; 1.
DR   Gene3D; 2.60.120.10; -; 1.
DR   InterPro; IPR018490; cNMP-bd-like.
DR   InterPro; IPR018488; cNMP-bd_CS.
DR   InterPro; IPR000595; cNMP-bd_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR013621; Ion_trans_N.
DR   InterPro; IPR030169; K/Na_HCN1.
DR   InterPro; IPR003938; K_chnl_volt-dep_EAG/ELK/ERG.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   PANTHER; PTHR10217:SF373; PTHR10217:SF373; 1.
DR   Pfam; PF00027; cNMP_binding; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF08412; Ion_trans_N; 1.
DR   PRINTS; PR01463; EAGCHANLFMLY.
DR   SMART; SM00100; cNMP; 1.
DR   SUPFAM; SSF51206; SSF51206; 1.
DR   PROSITE; PS00888; CNMP_BINDING_1; 1.
DR   PROSITE; PS50042; CNMP_BINDING_3; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002277};
KW   Ion channel {ECO:0000256|SAAS:SAAS00904115};
KW   Ion transport {ECO:0000256|SAAS:SAAS00502700};
KW   Membrane {ECO:0000256|SAAS:SAAS00502630, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00137614,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00137754,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|SAAS:SAAS00502637}.
FT   TRANSMEM    137    161       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    366    391       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      469    575       Cyclic nucleotide-binding.
FT                                {ECO:0000259|PROSITE:PS50042}.
SQ   SEQUENCE   603 AA;  68482 MW;  F842D65035BC06CA CRC64;
     MEGGGKPNSS SNSRDDGNSV FPAKASATGA GPAAAEKRLG TPPGGGGAGA KEHGNSVCFK
     VDGGGGGGEE PAGGFEDAEG PRRQYGFMQR QFTSMLQPGV NKFSLRMFGS QKAVEKEQER
     VKTAGFWIIH PYSDFRFYWD LIMLIMMVGN LVIIPVGITF FTEQTTTPWI IFNVASDTVF
     LLDLIMNFRT GTVNEDSSEI ILDPKVIKMN YLKSWFVVDF ISSIPVDYIF LIVEKGMDSE
     VYKTARALRI VRFTKILSLL RLLRLSRLIR YIHQWEEIFH MTYDLASAVV RIFNLIGMML
     LLCHWDGCLQ FLVPLLQDFP PDCWVSLNEM VNDSWGKQYS YALFKAMSHM LCIGYGAQAP
     VSMSDLWITM LSMIVGATCY AMFVGHATAL IQSLDSSRRQ YQEKYKQVEQ YMSFHKLPAD
     MRQKIHDYYE HRYQGKIFDE ENILNELNDP LREEIVNFNC RKLVATMPLF ANADPNFVTA
     MLSKLRFEVF QPGDYIIREG AVGKKMYFIQ HGVAGVITKS SKEMKLTDGS YFGEICLLTK
     GRRTASVRAD TYCRLYSLSV DNFNEVLEEY PMMRRAFETV AIDRLDRIGK KNSILLQKFQ
     KDL
//
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