ID H2QSN6_PANTR Unreviewed; 558 AA.
AC H2QSN6; A0A2J8NXW3;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE RecName: Full=Phosphatidylserine lipase ABHD16A {ECO:0000256|ARBA:ARBA00017746};
DE EC=3.1.1.23 {ECO:0000256|ARBA:ARBA00013254};
DE AltName: Full=Alpha/beta hydrolase domain-containing protein 16A {ECO:0000256|ARBA:ARBA00032559};
DE AltName: Full=Monoacylglycerol lipase ABHD16A {ECO:0000256|ARBA:ARBA00032975};
GN Name=ABHD16A {ECO:0000313|EMBL:JAA03161.1,
GN ECO:0000313|Ensembl:ENSPTRP00000030679.5,
GN ECO:0000313|VGNC:VGNC:11028};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000030679.5, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000030679.5, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|EMBL:JAA03161.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Adipose stromal {ECO:0000313|EMBL:JAA03161.1}, Skeletal muscle
RC {ECO:0000313|EMBL:JAA42299.1}, Skin {ECO:0000313|EMBL:JAA26082.1}, and
RC Smooth vascular {ECO:0000313|EMBL:JAA12803.1};
RA Maudhoo M.D., Meehan D.T., Norgren R.B.Jr.;
RT "De novo assembly of the reference chimpanzee transcriptome from NextGen
RT mRNA sequences.";
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSPTRP00000030679.5}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolyzes glycerol monoesters of long-chain fatty acids.;
CC EC=3.1.1.23; Evidence={ECO:0000256|ARBA:ARBA00001613};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the AB hydrolase superfamily. ABHD16 family.
CC {ECO:0000256|ARBA:ARBA00009709}.
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DR EMBL; AACZ04022799; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; GABC01008177; JAA03161.1; -; mRNA.
DR EMBL; GABF01009342; JAA12803.1; -; mRNA.
DR EMBL; GABD01007018; JAA26082.1; -; mRNA.
DR EMBL; GABE01002440; JAA42299.1; -; mRNA.
DR STRING; 9598.ENSPTRP00000076853; -.
DR ESTHER; pantr-g2hih9; ABHD16.
DR PaxDb; 9598-ENSPTRP00000030679; -.
DR Ensembl; ENSPTRT00000033205.6; ENSPTRP00000030679.5; ENSPTRG00000017977.6.
DR VGNC; VGNC:11028; ABHD16A.
DR eggNOG; KOG1553; Eukaryota.
DR GeneTree; ENSGT00940000160908; -.
DR HOGENOM; CLU_040705_2_0_1; -.
DR TreeFam; TF314267; -.
DR Proteomes; UP000002277; Chromosome 6.
DR Bgee; ENSPTRG00000017977; Expressed in cerebellar cortex and 21 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0047372; F:acylglycerol lipase activity; IEA:UniProtKB-EC.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR000073; AB_hydrolase_1.
DR PANTHER; PTHR12277; ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR12277:SF54; PHOSPHATIDYLSERINE LIPASE ABHD16A; 1.
DR Pfam; PF00561; Abhydrolase_1; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE 2: Evidence at transcript level;
KW Hydrolase {ECO:0000313|EMBL:JAA03161.1};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 60..84
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 96..116
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 281..408
FT /note="AB hydrolase-1"
FT /evidence="ECO:0000259|Pfam:PF00561"
SQ SEQUENCE 558 AA; 63262 MW; 492BBDEECD0D0544 CRC64;
MAKLLSCVLG PRLYKIYRER DSERAPASVP ETPTAVTAPH SSSWDTYYQP RALEKHADSI
LALASVFWSI SYYSSPFAFF YLYRKGYLSL SKVVPFSHYA GTLLLLLAGV ACLRGIGRWT
NPQYRQFITI LEATHRNQSS ENKRQLANYN FDFRSWPVDF HWEEPSSRKE SRGGPSRRGV
ALLRPEPLHR GTADTLLNRV KKLPCQITSY LVAHTLGRRM LYPGSVYLLQ KALMPVLLQG
QARLVEECNG RRAKLLACDG NEIDTMFVDR RGTAEPQGQK LVICCEGNAG FYEVGCVSTP
LEAGYSVLGW NHPGFAGSTG VPFPQNEANA MDVVVQFAIR RLGFQPQDII IYAWSIGGFT
ATWAAMSYPD VSAMILDASF DDLVPLALKV MPDSWRGLVT RTVRQHLNLN NAEQLCRYQG
PVLLIRRTKD EIITTTVPED IMSNRGNDLL LKLLQHRYPR VMAEEGLRVV RQWLEASSQL
EEASIYSRWE VEEDWCLSVL RSYQAEHGPD FPWSVGEDMS ADGRRQLALF LARKHLHNFE
ATHCTPLPAQ NFQMPWHL
//
