ID H2QU34_PANTR Unreviewed; 458 AA.
AC H2QU34;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=Sorting nexin 8 {ECO:0000313|Ensembl:ENSPTRP00000032199.2};
GN Name=SNX8 {ECO:0000313|Ensembl:ENSPTRP00000032199.2,
GN ECO:0000313|VGNC:VGNC:4513};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000032199.2, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000032199.2, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000032199.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004287};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004287};
CC Cytoplasmic side {ECO:0000256|ARBA:ARBA00004287}.
CC -!- SIMILARITY: Belongs to the sorting nexin family.
CC {ECO:0000256|ARBA:ARBA00010883}.
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DR EMBL; AC183379; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H2QU34; -.
DR Ensembl; ENSPTRT00000034835.2; ENSPTRP00000032199.2; ENSPTRG00000018859.2.
DR VGNC; VGNC:4513; SNX8.
DR eggNOG; KOG2273; Eukaryota.
DR GeneTree; ENSGT00460000041594; -.
DR HOGENOM; CLU_042580_0_0_1; -.
DR OMA; YLENKMV; -.
DR TreeFam; TF314082; -.
DR Proteomes; UP000002277; Chromosome 7.
DR Bgee; ENSPTRG00000018859; Expressed in testis and 21 other cell types or tissues.
DR GO; GO:0031410; C:cytoplasmic vesicle; IEA:UniProt.
DR GO; GO:0005829; C:cytosol; IEA:GOC.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0042147; P:retrograde transport, endosome to Golgi; IEA:InterPro.
DR CDD; cd07597; BAR_SNX8; 1.
DR CDD; cd06866; PX_SNX8_Mvp1p_like; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR028662; SNX8/Mvp1.
DR InterPro; IPR035704; SNX8/Mvp1_PX.
DR InterPro; IPR045734; Snx8_BAR_dom.
DR PANTHER; PTHR46571; SORTING NEXIN-8; 1.
DR PANTHER; PTHR46571:SF1; SORTING NEXIN-8; 1.
DR Pfam; PF00787; PX; 1.
DR Pfam; PF19566; Snx8_BAR_dom; 1.
DR SMART; SM00312; PX; 1.
DR SUPFAM; SSF64268; PX domain; 1.
DR PROSITE; PS50195; PX; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 66..174
FT /note="PX"
FT /evidence="ECO:0000259|PROSITE:PS50195"
FT REGION 1..31
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 458 AA; 51938 MW; 2BD62492F2845536 CRC64;
AFPDSGDPLT SRVAGTAKLA SEPPHLPTPQ AIEPQAIVQQ APAPSRMQMP QGNPLLLSHT
LQELLARDTV QVELIPEKKG LFLKHVEYEV SSQRFKSSVY RRYNDFVVFQ EMLLHKFPYR
MVPALPPKRM LGADREFIEA RRRALKRFVN LVARHPLFSE DVVLKLFLSF SGSDVQNKLK
ESAQCVGDEF LNCKLATRAK DFLPADIQAQ FAISRELIRN IYNSFHKLRD RAERIASRAI
DNAADLLIFG KELSAIGSDT TPLPSWAALN SSTWGSLKQA LKGLSVEFAL LADKAAQQGK
QEENDVVEKL SLFLDLLQSY KDLCERHEKG VLHKHQRALH KYSLMKRQMM SATAQNREPE
SVEQLESRIV EQENAIQTME LRNYFSLYCL HQETQLIHVY LPLTSHILRA FVNSQIQGHK
EMSKVWNDLR PKLSCLFAGP HSTLTPPCSP PEDGLCPH
//
