ID H2QVY6_PANTR Unreviewed; 796 AA.
AC H2QVY6; A0A2J8N8H0;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=Nuclear GTPase, germinal center associated {ECO:0000313|Ensembl:ENSPTRP00000034432.6};
GN Name=NUGGC {ECO:0000313|Ensembl:ENSPTRP00000034432.6,
GN ECO:0000313|VGNC:VGNC:2456};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000034432.6, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000034432.6, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000034432.6}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AACZ04065644; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_519681.4; XM_519681.5.
DR AlphaFoldDB; H2QVY6; -.
DR STRING; 9598.ENSPTRP00000034432; -.
DR PaxDb; 9598-ENSPTRP00000034432; -.
DR Ensembl; ENSPTRT00000037257.6; ENSPTRP00000034432.6; ENSPTRG00000020114.6.
DR GeneID; 464080; -.
DR CTD; 389643; -.
DR VGNC; VGNC:2456; NUGGC.
DR eggNOG; ENOG502QVUX; Eukaryota.
DR GeneTree; ENSGT00390000007091; -.
DR HOGENOM; CLU_019456_0_0_1; -.
DR InParanoid; H2QVY6; -.
DR OMA; IEQCFAH; -.
DR OrthoDB; 3604509at2759; -.
DR TreeFam; TF352086; -.
DR Proteomes; UP000002277; Chromosome 8.
DR Bgee; ENSPTRG00000020114; Expressed in liver and 5 other cell types or tissues.
DR GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR GO; GO:0071222; P:cellular response to lipopolysaccharide; IEA:Ensembl.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
DR GO; GO:0033262; P:regulation of nuclear cell cycle DNA replication; IEA:Ensembl.
DR CDD; cd00882; Ras_like_GTPase; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR045063; Dynamin_N.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR47308; NUCLEAR GTPASE SLIP-GC; 1.
DR PANTHER; PTHR47308:SF1; NUCLEAR GTPASE SLIP-GC; 1.
DR Pfam; PF00350; Dynamin_N; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002277}.
FT DOMAIN 103..323
FT /note="Dynamin N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00350"
FT REGION 1..35
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 796 AA; 91108 MW; 7A01CA97A16DA261 CRC64;
MAETKDVFGQ EPHPVEDDLY KEPTRKRRKS DRDQRFRAFP SMEQSALKEY EKLESRTRRV
LSNTYQKLIQ SVFLDDSIPN GVKYLINRLL ALIEKPTVDP IYIGLFGSTG AGKSSLINAI
IQQAMFLPVS GESICTSCIV QVSSGCCVQY EAKIHLLSDQ EWREELKNLT KLLHRTEELG
REEADAWNRD EAVEEATWKL QMIYGNGAES KNYEELLRAK PKRKIPTSRV ITLKAEEAEE
LSIKLDPYIR TQRRDWDGEA AEMRIWPLIK HVEVTLPKSD LIPEGVVLVD IPGTGDFNSK
RDEMWKKTID KCSVIWVISD IERVSGGRAH EDLLNESIKA CQRGFCRDVA LVVTKMDKLH
LPEYLRERKV GNQAIQSQRE AVLERNEMIK LQRTRILKEK LKRKLPADFK VLEASDLVYT
VSAQEYWQQA LLTEEETEIP KLREYIRKSL LDKKKRTVTK YVTEAFGLLL LTDSFNSTQN
LPNEHLHMSV LRRFAEEKVE LLEKAIAQCF ACMEQPLQEG VRTARTSYRC ILRACLVRSK
GNQGFHQTLK AVCLKNGIYA SRTLARIDLN EALTQPIYDQ IDPVFGSIFR TGKPTGSALM
PHIDAFKHSL QEKMTEIGIR SGWKYDSCKK NFLIQEISAI LGGLEDHILR RKRRIYESLT
ASVQSDLKLC YEEAAQITGK KACERMKDAI RRGVDWQVAE GMFERAQERM QHQFQQLKAG
IVEKVKGSIT TMLALASSQG DGLYKELADV GSEYKEMEKL HRSLREVAEN ARLRKGMQEF
LLRASPSKAG PPGTSL
//
