ID H2QWT3_PANTR Unreviewed; 577 AA.
AC H2QWT3;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=Cytochrome P450 family 11 subfamily B member 1 {ECO:0000313|Ensembl:ENSPTRP00000035298.5};
GN Name=CYP11B1 {ECO:0000313|Ensembl:ENSPTRP00000035298.5,
GN ECO:0000313|VGNC:VGNC:6562};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000035298.5, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000035298.5, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000035298.5}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=heme; Xref=ChEBI:CHEBI:30413;
CC Evidence={ECO:0000256|ARBA:ARBA00001971,
CC ECO:0000256|PIRSR:PIRSR602403-1};
CC -!- SIMILARITY: Belongs to the cytochrome P450 family.
CC {ECO:0000256|ARBA:ARBA00010617, ECO:0000256|RuleBase:RU000461}.
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DR EMBL; AACZ04062105; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H2QWT3; -.
DR Ensembl; ENSPTRT00000038181.5; ENSPTRP00000035298.5; ENSPTRG00000020644.4.
DR VGNC; VGNC:6562; CYP11B1.
DR eggNOG; KOG0159; Eukaryota.
DR GeneTree; ENSGT00940000163354; -.
DR HOGENOM; CLU_001570_28_4_1; -.
DR InParanoid; H2QWT3; -.
DR TreeFam; TF105094; -.
DR Proteomes; UP000002277; Chromosome 8.
DR Bgee; ENSPTRG00000020644; Expressed in testis.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProt.
DR GO; GO:0005743; C:mitochondrial inner membrane; IBA:GO_Central.
DR GO; GO:0047783; F:corticosterone 18-monooxygenase activity; IBA:GO_Central.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0004507; F:steroid 11-beta-monooxygenase activity; IBA:GO_Central.
DR GO; GO:0032342; P:aldosterone biosynthetic process; IBA:GO_Central.
DR GO; GO:0071375; P:cellular response to peptide hormone stimulus; IBA:GO_Central.
DR GO; GO:0035865; P:cellular response to potassium ion; IEA:Ensembl.
DR GO; GO:0008203; P:cholesterol metabolic process; IBA:GO_Central.
DR GO; GO:0034651; P:cortisol biosynthetic process; IEA:Ensembl.
DR GO; GO:0034650; P:cortisol metabolic process; IBA:GO_Central.
DR GO; GO:0006704; P:glucocorticoid biosynthetic process; IBA:GO_Central.
DR GO; GO:0008217; P:regulation of blood pressure; IEA:Ensembl.
DR CDD; cd20644; CYP11B; 1.
DR Gene3D; 1.10.630.10; Cytochrome P450; 1.
DR InterPro; IPR001128; Cyt_P450.
DR InterPro; IPR017972; Cyt_P450_CS.
DR InterPro; IPR002403; Cyt_P450_E_grp-IV.
DR InterPro; IPR036396; Cyt_P450_sf.
DR PANTHER; PTHR24279; -; 1.
DR PANTHER; PTHR24279:SF115; CYTOCHROME P450 11B1, MITOCHONDRIAL; 1.
DR Pfam; PF00067; p450; 1.
DR PRINTS; PR00465; EP450IV.
DR PRINTS; PR00385; P450.
DR SUPFAM; SSF48264; Cytochrome P450; 1.
DR PROSITE; PS00086; CYTOCHROME_P450; 1.
PE 3: Inferred from homology;
KW Heme {ECO:0000256|ARBA:ARBA00022617, ECO:0000256|PIRSR:PIRSR602403-1};
KW Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|PIRSR:PIRSR602403-1};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRSR:PIRSR602403-1};
KW Monooxygenase {ECO:0000256|RuleBase:RU000461};
KW Oxidoreductase {ECO:0000256|RuleBase:RU000461};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Transit peptide {ECO:0000256|ARBA:ARBA00022946}.
FT BINDING 524
FT /ligand="heme"
FT /ligand_id="ChEBI:CHEBI:30413"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="axial binding residue"
FT /evidence="ECO:0000256|PIRSR:PIRSR602403-1"
SQ SEQUENCE 577 AA; 65437 MW; C5447BF3244E9610 CRC64;
MALRAKAEVC MAVPWLSLQR AQALGTRAAR VPRTVLPFEA MPRHPGNRWL RLLQIWREQG
YEDLHLEVHQ TFQELGPIFR SRHSASFGRW GRSAARAGLW RCQGRGWCRA NPSSLQRGQD
SEALKYDLGG AGMVCVMLPE DVEKLQQVDS LHPHRMSLEP WVAYRQHRGH KCGVFLLHFV
GNVADRGNSF PPLPGGIHGL CPGLCRNGPE WRFNRLRLNP EVLSPKAVQR FLPMVDAVAR
DFSQALKKKV LQNARGSLTL DVQPSIFHYT IEASNLALFG ERLGLVGHSP SSASLNFLHA
LEVMFKSTVQ LMFMPSSLSR WISPKVWKEH FEAWDCIFQY GDNCIQKIYQ ELAFSRPQQY
TSIVAELLLN AELSPDAIKA NSMELTAGSV DTTVFPLLMT LFELARNPDV QQALRQESLA
AAASISEHPQ KATTELPLLR AALKETLRLY PVGLFLERVA SSDLVLQNYH IPAGTLVRVF
LYSLGRNPAL FPRPERYNPQ RWLDIRGSGR NFYHVPFGFG MRQCLGRRLA EAEMLLLLHH
VLKHLQVETL TQEDIKMVYS FILRPSTFPL LTFRAIN
//
